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Elimination through a conjugate base formed before leaving-group departure. The measured kinetic order depends on whether deprotonation equilibrates and which step limits the rate.
Interaction of a filled sigma bond with a neighboring empty or partially occupied orbital. Orbital alignment controls its stabilizing influence and secondary isotope effects.
An alkene with two oxygen substituents on one alkene carbon. Allylic ketene acetals rearrange to unsaturated esters.
An atom at which exchange of two substituents produces a stereoisomer. A tetrahedral carbon with four distinct substituents is a familiar example.
A mechanistic correlation by which different reactant stereoisomers lead to different product stereoisomers.
Construction of organic compounds through controlled transformations of simpler precursors.
An energetic penalty from bond angles, torsions or nonbonded contacts forced away from favourable values by ring closure.
Acid-promoted union of a carbonyl-derived oxocarbenium ion with a tethered alkene to form a ring. Cation trapping and the preferred cyclization conformation determine the final substitution and stereochemistry.
NMR relaxation dispersion measures how an observed nuclear-spin relaxation rate changes with pulse timing or effective field conditions. Models can constrain exchange between molecular environments, including weakly populated conformations; rate and population estimates depend on the exchange model and information content.
Through-bond interaction between nuclear spins that splits NMR resonances. In the weak-coupling limit, equivalent spin- neighbours produce lines with binomial coefficient intensities. Equivalent nuclei do not split each other.
Irradiation that removes resolved scalar spin-spin coupling to protons from another nucleus’s spectrum. Other couplings, such as carbon–fluorine coupling in a proton-decoupled carbon-13 NMR spectrum, can remain.
NMR observation of spin- carbon-13 nuclei. Routine spectra often use proton decoupling, but this does not automatically decouple other spin-active nuclei.
NMR observation of spin- fluorine-19 nuclei. Coupling to nearby protons can split a resonance unless proton decoupling is applied.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact