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Study of relationships between anatomical construction and mechanical or physiological function.
A signalling protein important in vertebrate pattern formation, including the limb. Signal duration, position and responding tissue affect interpretation of digit-patterning experiments.
It can bind nuclear receptors that regulate transcription, connecting a vitamin-derived signal to developmental gene programmes. Local synthesis and removal help determine where cells receive the signal. A measured concentration pattern and the responding tissue’s competence are therefore separate parts of a patterning mechanism. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 21, Mechanisms of Development: retinoic acid and pattern formation
molecular dynamics simulates time evolution of a molecular system using a chosen interaction model. Simulated pathways and state populations require adequate sampling and validation against measured observables; a plausible trajectory alone does not establish a biological mechanism.
An adenosine modification bearing a methyl group on the exocyclic N6 nitrogen. Its presence can alter recognition by an RNA-binding protein directly or through RNA secondary structure.
Reactive oxygen species include oxygen-derived reactive species with different chemical and electronic properties. Their generation, detoxification and damage pathways should not be treated as one universal reaction.
Aromaticity describes the distinctive stability and associated electronic properties of suitable cyclic delocalized systems. In simple planar conjugated rings, orbital occupancy determines whether delocalization is stabilizing; merely drawing a ring is insufficient.
A heterocyclic compound contains a ring with at least one atom other than carbon. Nitrogen, oxygen, and sulfur are common heteroatoms.
For example, pyrrolidine has a saturated nitrogen-containing ring, while pyridine is aromatic. Having a heteroatom does not by itself imply aromaticity; ring conjugation and electron occupancy determine that separate property.
A side chain is a group attached to a main molecular framework. In a protein, the amino-acid side chain is the variable group attached to the backbone alpha carbon; in a polymer, it is a substituent branching from the backbone.
The choice of backbone is part of the description. Amino-acid side chains influence charge, hydrophobicity, and molecular recognition, while polymer side chains can alter flexibility and solubility without changing the main-chain connectivity.
An assembly of two molecular subunits.
The functional form and parameters defining a molecular-mechanics potential. A classical fixed-topology force field normally cannot describe arbitrary changes in bonding or electronic excitation.
The microbial community and associated genetic or functional information in a specified environment; the exact operational definition should be stated.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact