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A layered compound . Atomically thin films are used in electronic and optical devices; crystal phase, defects, thickness and the local environment affect their response.
Lithium hexamethyldisilazide is the lithium salt of , a bulky amide anion. It is used as a strong base for transformations such as enolate formation.
The lithium ion can coordinate oxygen donors and organize aggregates. Consequently, calling the reagent non-nucleophilic is a useful comparison under specified conditions, not a claim that it cannot participate in any competing reaction.
[ref]
https://doi.org/10.1021/jacs.7b05057. Primary enolization study: aggregation, solvent and E-Z selectivity; supporting NMR and rate measurements
Trimethylsilyl chloride is . Reaction of an oxygen nucleophile at silicon can replace chloride and form a trimethylsilyl ether.
Trapping an enolate on oxygen forms a silyl enol ether. This preserves an enol-derived carbon-carbon double bond while changing the species' charge and handling properties.
Trimethylsilyl triflate has connectivity . It transfers a trimethylsilyl group to suitable nucleophilic sites, commonly oxygen.
The weakly coordinating triflate group makes silicon highly electrophilic relative to many less reactive silyl reagents. Silylation can protect an alcohol or change the reactivity of a carbonyl-containing intermediate.
[ref]
https://www.tcichemicals.com/JP/en/product/tci-topics/TCIPracticalExample_20250324. TCI original example, 24 March 2025: alpha-tetralone converted to a silyl enol ether
Potassium hexamethyldisilazide is the potassium salt of the anion . The bulky silyl groups make it useful as a strong, sterically hindered base.
It can remove an acidic proton to form an enolate while competing less readily in some addition reactions than a smaller nucleophile. Counterion, solvent, and aggregation still influence the observed selectivity.
[ref]
https://www.suparnachemicals.co.in/pdf-new/alkali-metal-amides/potasium-hexametyane/potassium-hexsmetyane-didilazane.pdf. Manufacturer technical specification: strong base, deprotonation and kinetic enolate formation
An anionic species with a negatively charged carbon centre. Resonance stabilization and substituents control its basicity and nucleophilicity.
The hydride reagent . Its comparatively mild reactivity permits selected imine and iminium reductions.
The oxonium salt , a strong methylating reagent. carbonyl O-methylation followed by alpha-deprotonation can form an enol ether.
The methylating reagent . Nucleophilic attack at methyl displaces fluorosulfonate.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact