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Luiz C. Dias investigated stereoselective preparation of biologically active natural products. His account uses a specific epoxidation sequence to connect synthetic planning with control of stereochemistry, rather than treating formation of the carbon skeleton as the only goal.[ref]
Recent results toward the stereoselective synthesis of biologically active natural products by Luiz C. Dias and others. 2007 author account, Scheme2 and epoxidation discussion
Philip DeShong investigated total synthesis of tirandamycin A. In the reported sequence, related pyranones were converted into a fused lactone; the discussion used a proposed mechanism to qualify the relative stereochemistry, rather than claiming that the reported NMR spectroscopy alone fixed the assignment unambiguously.[ref]
Total synthesis of (±)-tirandamycin A by Philip DeShong and others. 1985, pp.5220–5221, Schemes II–III and stereochemical-assignment discussion
Werner Uhl coauthored research on carbaalanes, clusters containing aluminium and carbon. A reported transformation hydroaluminates unsaturated groups while forming a capped aluminium-cube framework.
The example connects addition at an organic multiple bond with reorganization of a metal-carbon cluster. Both external substituents and the cluster skeleton must therefore be tracked when describing the product.[ref]
New Carbaalanes Containing Clusters of Aluminum and Carbon Atoms by Werner Uhl and others. Abstract: unsaturated groups, hydroalumination, and capped cube
Portrait of Werner Uhl
. Jü (Commons author field). CC BY-SA 4.0, via Wikimedia Commons. Source.David A. Long investigated spectral parameters of rare oxygen isotopologues for atmospheric remote sensing. The molecular analysis distinguishes rotational angular momentum from total angular momentum and accounts for nuclear-spin restrictions on the allowed rotational levels.[ref]
Victor K. La Mer developed, with Robert H. Dinegar, a model linking nucleation and particle growth to the formation of monodisperse sulfur hydrosols. A brief nucleation interval followed by growth provides a mechanism for narrowing the spread of particle sizes.[ref]
Theory, Production and Mechanism of Formation of Monodispersed Hydrosols by Victor K. La Mer and Robert H. Dinegar. 1950, sulfur-hydrosol nucleation/growth model; no claim of universality for nanoparticle syntheses
Robert H. Dinegar helped develop a model for producing monodisperse sulfur hydrosols. Separating a short period of nucleation from subsequent particle growth explains how particles can begin growing at similar times and acquire a narrow size distribution.[ref]
Theory, Production and Mechanism of Formation of Monodispersed Hydrosols by Victor K. La Mer and Robert H. Dinegar. 1950, initial discussion of sulfur-hydrosol nucleation and growth; scope limited to the reported model
Electrolytic purification by transferring the desired metal from an impure dissolving anode to a purer cathode. Impurities can stay dissolved, remain as solids or form precipitated anode slime. Potential control, transport and exclusion of solid contamination are as important as tabulated standard potentials.
David C. Grahame developed a quantitative treatment of the electric double layer and electrocapillarity. His analysis combined the Poisson equation with the Boltzmann distribution and distinguished accumulated interfacial charge, integral capacitance, and differential capacitance.[ref]
The Electrical Double Layer and the Theory of Electrocapillarity by David C. Grahame. 1947, section VI, pp.470–474, equations43–48
A linear string encoding atoms, bonds, branches, ring closures and optionally stereochemistry of a molecular graph.
Biotin is a small sulfur-containing cofactor used by enzymes that transfer carboxyl groups. Covalent attachment to a lysine side chain lets protein-bound biotin carry a carboxyl group between catalytic sites.[ref]
https://iubmb.qmul.ac.uk/enzyme/EC6/3/4/14.html. IUBMB EC 6.3.4.14: protein-bound biotin carboxylation and acetyl-CoA carboxylase
Dimethylformamide is the amide , commonly abbreviated DMF. It is a polar aprotic solvent with a carbonyl oxygen that can interact with dissolved ions.
The solvent changes both solvation and molecular association. In protein engineering, activity in concentrated DMF can depend separately on folding, stability, and catalytic chemistry; one measurement does not identify which property changed.
Glucose-6-phosphate is glucose phosphorylated at carbon 6. It links glucose trapping to pathways including glycolysis and glycogen synthesis; accumulation of this product and the incoming phosphorylation flux are different quantities.
Fructose-6-phosphate is a phosphorylated sugar involved in glycolysis and metabolic regulation. In liver glucose sensing it favours the inhibitory glucokinase–regulatory-protein interaction.
Fructose-1-phosphate is a product of fructose phosphorylation. It can antagonize the inhibitory glucokinase–regulatory-protein interaction, linking hepatic glucose handling to fructose metabolism.
Phosphocreatine buffers ATP supply through reversible phosphate transfer catalysed by creatine kinase. Its depletion and recovery during muscle exercise can be followed using phosphorus NMR spectroscopy.
The conjugate base of acetic acid.
A four-membered cyclic amide. Hydrolytic opening of this ring is a major mechanism by which beta-lactamases inactivate susceptible antibiotics.
Imidazole is a five-membered aromatic heterocycle with nitrogen atoms at positions 1 and 3. In a neutral form, the two nitrogens have different lone-pair roles: one pair participates in the aromatic system and the other is available for proton acceptance or metal binding.
The ring occurs in the histidine side chain. Free imidazole can compete with histidine contacts during immobilized metal affinity chromatography, helping control protein retention and elution.
[ref]
Organic Chemistry by John McMurry. Chapter24, Amines and Heterocycles: imidazole and the distinct roles of nitrogen lone pairs
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact