For the full-column-rank design matrix, the normal-error maximum-likelihood estimator is the least-squares estimator
Indeed maximizing the Gaussian likelihood over minimizes , whose normal equations are ; rank makes invertible. Substitution of the model gives
Since , it follows that , proving unbiasedness.
Independence and common error variance give . For the fixed matrix , the covariance transformation rule gives
Thus the covariance is determined by the error variance and the inverse Gram matrix of the design columns.
The design columns are , and . Their pairwise inner products are zero by the three supplied sums. Put and , positive under the full-rank assumption. Then
Applying part (a),
The off-diagonal covariances vanish because the design columns are orthogonal. With Gaussian errors, the coefficient estimators are also jointly normal and therefore independent.
The future mean response is . By invariance of maximum likelihood estimation, its estimator is the fitted mean
Its sampling variance is the quadratic form of the coefficient covariance matrix with :
This estimator is unbiased because each fitted coefficient is unbiased. The future error does not enter the estimator of the mean, so its independent variance is not part of this expression.

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