Movement of RNA from the nucleus to the cytoplasm in the relevant eukaryotic pathway. Processing, recognition and quality control can be coupled to export; export is distinct from transcription or subsequent translation.
The spatial distribution and targeting of messenger RNA within a biological cell. concentration enrichment, total fraction recruited, residence time and transport are different observables.
The ratio of RNA concentration inside an assembly to that outside, with accessible volumes and molecule detection specified. A high concentration ratio does not mean a large fraction of all cellular molecules is recruited.
Degradation of RNA molecules. RNA abundance reflects both production and decay, so a steady-state abundance difference alone does not establish a change in stability.
An RNA sequence element enriched in adenine and uracil that can recruit regulatory proteins affecting RNA stability.
The time for half of an RNA population to disappear under specified conditions. For a homogeneous first-order decay process it equals ; ongoing synthesis and changing biological cell states complicate abundance measurements.
Artificial recruitment of a candidate effector to a chosen RNA through a separate recognition module. It tests activity after recruitment while bypassing native recognition; physiological targeting and necessity require independent evidence.
Control of the rate or pattern of biological translation. ribosome occupancy depends on initiation and passage, so more occupied ribosomes need not mean more completed protein.
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Post-transcriptional regulation refers to the control of gene expression at the RNA level after the transcription process, where the DNA is transcribed into messenger RNA (mRNA). This regulation can affect various stages of RNA processing and ultimately influence the amount and functionality of the resulting proteins.