Sequence-directed regulation guided by small RNAs, often through Argonaute. Its effects can include transcript destruction, repression of biological translation or recruitment of repressive chromatin, depending on the pathway.
Generation of small regulatory RNAs without Dicer cleavage. Piwi-interacting RNA production and nematode RNA-dependent RNA polymerase-generated secondary RNAs are important examples.
An Argonaute-containing effector complex guided by small RNA. Target binding can produce cleavage, translational repression or RNA destabilization depending on the guide, effector and target.
A short RNA that guides sequence-specific silencing through an Argonaute protein; different pathways use different lengths and targets.
A class of Caenorhabditis elegans secondary small RNAs with a characteristic 5′ guanine and approximately 22-nucleotide length, generated by RNA-dependent RNA polymerases.
A fission-yeast small-RNA-guided chromatin silencing complex including Argonaute and a methyl-mark-binding component.[ref]

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