Zhong Zhong and Hua Hua are the names of two Chinese macaques that were the first primates to be cloned from somatic cells using the same technique that produced Dolly the sheep. They were created in January 2018 by a team of researchers at the Chinese Academy of Sciences. The cloning process used was called somatic cell nuclear transfer (SCNT), where the nucleus of a somatic cell is transferred into an egg cell that has had its own nucleus removed.
Zfp82, or zinc finger protein 82, is a member of the zinc finger protein family, which is characterized by the presence of zinc finger motifs. These motifs are specialized structural domains that can interact with DNA, RNA, or proteins, functioning primarily as transcription factors that regulate gene expression. The Zfp82 protein is involved in various biological processes, including development, cell differentiation, and possibly in the regulation of hormonal signaling.
ZMapp is an experimental therapeutic drug that was developed for the treatment of Ebola virus disease. It is a type of monoclonal antibody therapy, which means it is designed to target and neutralize the Ebola virus in the body. ZMapp was created by combining three different monoclonal antibodies that can bind to the virus and help the immune system fight off the infection.
A Yeast Artificial Chromosome (YAC) is a vector used to clone DNA fragments in yeast cells, particularly Saccharomyces cerevisiae. YACs are capable of carrying large inserts of DNA, ranging from 100 kilobases to over a million base pairs, making them particularly useful for cloning large genes or genomic regions.
XDNA can refer to different concepts depending on the context, but generally, it relates to cryptocurrency and blockchain technology. Specifically, XDNA is a digital currency that utilizes a unique algorithm to promote decentralization and privacy. It may involve features like smart contracts, secure transactions, and a focus on community governance. Further, XDNA may also be associated with specific projects or initiatives within the tech and blockchain space.
WikiPathways is an online platform that provides a collaborative environment for the creation and maintenance of pathways related to biological processes. It functions similarly to Wikipedia but is specifically focused on biological pathways, which are sequences of interactions between molecules within cells that result in a specific biological outcome. The platform allows researchers, scientists, and educators to contribute to the knowledge base by adding, editing, and updating pathways. These pathways can include information about metabolic routes, cellular signaling, gene regulation, and more.
Whole genome sequencing (WGS) is a comprehensive method used to determine the complete DNA sequence of an organism's genome at a single time. This process involves analyzing all of an organism's genetic material, including coding regions (genes) and non-coding regions, providing a complete picture of the genetic information contained in the genome.
"Wetware" is a term that typically refers to the biological aspects of living systems, particularly in contrast to hardware (physical components) and software (programmatic components). In various fields, such as computing, biology, and neuroscience, wetware emphasizes the biological substrates and processes that enable complex functions. In computing, wetware is often used to describe the human brain and nervous system's functions as they relate to computing processes.
Western blot is a widely used analytical technique in molecular biology and biochemistry to detect and quantify specific proteins in a sample. The process involves several key steps: 1. **Sample Preparation**: Proteins are extracted from cells or tissues and denatured, usually by heating and adding a reducing agent, to ensure that they unfold and are separated by size.
WebGeSTer is a web-based tool designed for the visualization and analysis of genomic sequence data, particularly focused on genomic structural variants like structural rearrangements, copy number variations, and other complex genomic features. It aims to provide researchers with an accessible platform to explore and interpret genomic data efficiently. WebGeSTer typically allows users to: 1. **Visualize Genomic Data:** Users can view genomic information in a user-friendly interface, facilitating the interpretation of complex data sets.
The Warburg hypothesis, proposed by the German biochemist Otto Warburg in the 1920s, suggests that cancer cells primarily rely on aerobic glycolysis for energy production, even in the presence of sufficient oxygen, which is different from normal cells that typically generate energy through oxidative phosphorylation in the mitochondria. This phenomenon, known as the "Warburg effect," indicates that cancer cells preferentially convert glucose to lactate instead of fully oxidizing it to carbon dioxide and water.
As of my last update in October 2023, "Virokine" does not refer to a widely recognized term or a specific product in mainstream science or medicine. It's possible that it could be a term related to antiviral therapy, a novel biotechnology product, or a proprietary drug under development that has emerged after my last knowledge update.
ViroCap is a comprehensive viral sequencing and detection technology designed to identify a wide range of viruses in clinical samples. It employs a hybrid capture approach, allowing researchers and clinicians to capture and sequence viral nucleic acids from a variety of specimens, including blood, respiratory, and other fluid samples. ViroCap typically utilizes a set of probes that are specific to known viral sequences, enabling it to enrich viral material from complex samples for high-throughput sequencing.
Viral transformation refers to the process by which a virus alters the biological properties of a host cell, leading to changes in cell behavior, growth, and function. This phenomenon is particularly significant in the context of certain viruses that can induce oncogenesis, the process by which normal cells become cancerous. Key aspects of viral transformation include: 1. **Oncogenic Viruses**: Some viruses, known as oncogenic or tumor viruses, can insert their genetic material into the host cell's genome.
Vibrational circular dichroism (VCD) is a spectroscopic technique that measures the difference in the absorption of left-handed and right-handed circularly polarized light by chiral molecules. It is particularly useful for studying the chiral properties of molecules, which is important in fields such as chemistry, biochemistry, and pharmacology, where the 3D structure and its chiral configuration can significantly impact the behavior and interactions of molecular species.
Viability PCR (v-PCR) is a molecular biology technique used to differentiate live cells from dead cells in a sample, particularly in microbial analysis. This method leverages the polymerase chain reaction (PCR) to amplify genetic material from viable organisms while selectively excluding the genetic material from non-viable (dead) cells.
Veterinary virology is a specialized branch of veterinary medicine that focuses on the study of viruses that infect animals. This field encompasses various aspects, including the identification, characterization, and understanding of viral pathogens that cause diseases in domestic and wild animals. Veterinary virologists investigate the biology of these viruses, including their structure, genetics, and mechanisms of infection, as well as their interactions with the host's immune system.
Vertical resistance refers to the resistance that is encountered when an electric field is applied in a direction that is perpendicular (or vertical) to the surface of a material. This term is often used in the context of various types of materials, particularly in the fields of electronics, materials science, and geotechnical engineering. In the context of electrical engineering, vertical resistance can be significant in measuring the performance and behavior of semiconductor devices, capacitors, and other components when subjected to an electric field.
In gene therapy, a vector refers to a vehicle used to deliver therapeutic genes into a patient's cells. The primary purpose of using vectors is to ensure that the introduced genetic material can effectively enter the target cells, express the desired protein, and potentially correct or alleviate the underlying cause of a genetic disorder. Vectors can be broadly categorized into two types: viral vectors and non-viral vectors. ### 1.
Vectorette PCR is a molecular biology technique used to amplify specific DNA sequences from complex mixtures. It's particularly useful for isolating and amplifying sequences from genomic DNA when working with certain types of samples, such as those where the target sequence is flanked by unknown or non-specific DNA. The technique involves the use of a "vectorette" — a short, known DNA sequence that is ligated to the ends of the target DNA fragments.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact