Brain by species by Ciro Santilli 35 Updated +Created
Drosophila connectome by Ciro Santilli 35 Updated +Created
The hard part then is how to make any predictions from it:
  • 2024 www.nature.com/articles/d41586-024-02935-z Fly-brain connectome helps to make predictions about neural activity. Summary of "Connectome-constrained networks predict neural activity across the fly visual system" by J. K. Lappalainen et. al.
2024: www.nature.com/articles/d41586-024-03190-y Largest brain map ever reveals fruit fly's neurons in exquisite detail
As of 2022, it had been almost fully decoded by post mortem connectome extraction with microtome!!! 135k neurons.
That article mentions the humongous paper elifesciences.org/articles/66039 elifesciences.org/articles/66039 "A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection" by a group from Janelia Research Campus. THe paper is so large that it makes eLife hang.
Operon vs transcription unit by Ciro Santilli 35 Updated +Created
That single operon can produce two different mRNA transcription units:
The reason for this appears to be that there is a rho-independent termination region after thrL. But then under certain conditions, that must get innactivated, and then the thrLABC is produced instead.
Operon by Ciro Santilli 35 Updated +Created
Sequence of genes under a single promoter. For an example, see E. Coli K-12 MG1655 operon thrLABC.
A single operon may produce multiple different transcription units depending on certain conditions, see: operon vs transcription unit.
Sirius by Ciro Santilli 35 Updated +Created
This is quite close! But as mentioned at: stars nearest to the Sun, there are several others nearby. Notably Sirius at 9 ly, the brightest star in the sky as of 2020.
Post-transcriptional modification by Ciro Santilli 35 Updated +Created
Transcription (biology) by Ciro Santilli 35 Updated +Created
RNA secondary structure by Ciro Santilli 35 Updated +Created
Analogous problem to the secondary structure of proteins. Likely a bit simpler due to the strong tendency for complementary pairs to bind.
RNA by Ciro Santilli 35 Updated +Created
Bisulfite sequencing by Ciro Santilli 35 Updated +Created
The main way to sequence DNA methylation. Converts methylated cytosine to uracil, and then we can sequence those.
Video 1.
Bisulfite Sequencing by Henrik's Lab (2020)
Source. Nothing much new that we don't understand from a single sentence in the animation. But hey, animations!
DNA methylation by Ciro Santilli 35 Updated +Created
The first found and most important known epigenetic marker.
Happens only on adenine and cytosine. Adenine methylation is much less common in mammal than cytosine methylation, when people say "methylation" they often mean just cytosine methylation.
It often happens on promoters, where it inhibits transcription.
De novo DNA synthesis company by Ciro Santilli 35 Updated +Created
Biasing by Ciro Santilli 35 Updated +Created
Diode bridge by Ciro Santilli 35 Updated +Created

Pinned article: ourbigbook/introduction-to-the-ourbigbook-project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    • to OurBigBook.com to get awesome multi-user features like topics and likes
    • as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact