Structure of the mitochondria Updated 2025-07-16
UPDATE with JOIN (SQL) Updated 2025-07-16
Dumping examples under nodejs/sequelize/raw/many_to_many.js.
Not possible without subqueries in the standard syntax, a huge shame: stackoverflow.com/questions/1293330/how-can-i-do-an-update-statement-with-join-in-sql-server
DNA sequencing milestone Updated 2025-07-16
Most of these are going to be Whole-genome sequencing of some model organism:en.wikipedia.org/wiki/Whole_genome_sequencing#History lists them all. Basically th big "firsts" all happened in the 1990s and early 2000s.
- 1975 by Sanger et al.: 5 kbp of the single-stranded bacteriophage ΦX174 using Sanger's radiolabelling method
- 1981 by Sanger et al.: 17 kbp of human mitochondrial DNA via Sanger method, known as the Cambridge Reference Sequence
- 2003: Human Genome Project (3 Gbp)
Flatpak Updated 2025-07-16
diff Updated 2025-07-16 Mitochondrial DNA Updated 2025-07-16
Non-POSIX command line utility Updated 2025-07-16
Nucleoid Updated 2025-07-16
Power, Sex, Suicide by Nick Lane (2006) Updated 2025-07-16
All pages below are from the second edition from 2018. It seems that there weren't any changes in the text, the updated preface mentions
As it happens, nearly 15 years have passed since the 1st edition of Power, Sex, Suicide was published, and I am resisting the temptation to make any lame revisions. Some say that even Darwin lessened the power of his arguments in the Origin of Species through his multiple revisions, in which he dealt with criticisms and sometimes shifted his views in the wrong direction. I prefer my original to speak for itself, even if it turns out to be wrong.
This is partly addressed in the preface of the second edition from 2018.
Central thesis:
- there are two sexes because of mitochondria
- the acquisition of mitochondria was one of the most important steps in the evolution of eukaryotes.There are no known eukaryotes which never had mitochondria. Having mitochondria appears to be a requisite for being an eukaryote.Contrast this for example with multicellularity, which is highly polyphyletic.
- Apoptosis is largely regulated by mitochondria
- there are two main theories for how the mitochondria endosymbiosis started:
- parsitic hypothesis of mitochondrial endosymbiosis: a parasitic option rather than cooperative
- hydrogen hypothesis: a cooperative option rather than parasitic
Smaller points:
- 10% of our body weight (dry presumably?) is mitochondria. Also quoted at: www.nature.com/scitable/blog/student-voices/mighty_mitochondria. TODO confirm.
- eukaryotes can do phatocytosis due to their cytoskeleton
- paints a colorful picture of Peter Mitchell. Some Wikipedia edits are warranted!
- it is hard for complex organisms to evolve because longer DNA means longer replication time
- cancer is natural selection gone wrong
- multicellular organisms are not utopias where every cell lives happily. Rather, they are dictatorships, where any dissident is forced to commit seppuku. Lu Xun's petition quote comes to mind.
Nitpicks:
- the book calls ATP synthase "ATPase" in several points, which is confusing because -ase means "something that breaks", and in 2020 parlance, there are ATPases which actually break ATP: en.wikipedia.org/wiki/ATPase. The book itself acknowledges that on page 135:
The ATPase is freely reversible. Under some circumstances it can go into reverse, whereupon it splits ATP, and uses the energy released to pump protons up the drive shaft, back across the membrane against the pressure of the reservoir. In fact the very name ATPase (rather than ATP synthase) signifies this action, which was discovered first. This bizarre trait hides a deep secret of life, and we’ll return to it in a moment.
Some criticisms:
- some of the later chapters are a bit more boring, like the stuff about warm-blooded animals. Perhaps is it that Ciro Santilli is more interested in the molecular aspects than macro
- the author talks about some very recent research at the time. While this does highlight his expertise, some of the points mentioned might still be in a state of flow. This is acknowledged by the author himself on the 2018 updated preface however.
SoundFont Updated 2025-07-16
Contains instructions on how to synthesize MIDI.
Extension: sf2.
Can be imported for example by:
- vmpk
- Csound with
sfload: www.csounds.com/manual/html/sfload.html
Uniqueness theorem for Poisson's equation Updated 2025-07-16
Elementary particle Updated 2025-07-16
The opposite of quasiparticle, see notaby: quasiparticles vs elementary particles.
Urho3D Updated 2025-07-16
Their project lead as of 2018 was pro-CCP: github.com/cirosantilli/china-dictatorship/blob/aa1176c57fc2929465294e520b43b50d44e202ba/communities-that-censor-politics.md
Usenet personality Updated 2025-07-16
Ciro Santilli does the same via Google searches and Twitter/Reddit searches for himself, you can't invent anything new nowadays:
Kibo was known for his high-volume but thoughtful posts, but achieved Usenet celebrity circa 1991 by writing a small script to grep his entire Usenet feed for instances of his name, and then answering personally whenever and wherever he was mentioned, giving the illusion that he was personally reading the entire feed.
Why can't you send voice without modulation? Updated 2025-07-16
Basically, the antenna has to be very, very large, more comparable to wavelength. E.g. even for the higher pitches, we fall in very low frequency, so have a look at the size of some of the submarine VLF antennas! They are like football pitch sized.
Zen of Python Updated 2025-07-16
QuTech Updated 2025-07-16
User mode emulation Updated 2025-07-16
User mode emulation refers to the ability of certain emulators to emulate userland code running on top of a specific operating system, usually Linux.
For example, QEMU allows you to run a variety of userland ELF programs directly on it, without an underlying Linux kernel running.
User mode emulation is achieved by implementing system calls and special filesystems such as
/dev manually on the emulator one by one.The general tradeoff is that simulation is less acurate as it may lack certain highly advanced kernel functionality you haven't implemented yet. But it is much easier to run executables with it, and you don't have to wait for boot to finish before running, you just run executables directly from the command line.
Use The Source Luke Updated 2025-07-16
Vaporware Updated 2025-07-16
There are unlisted articles, also show them or only show them.