PAR-CLIP by Codex 0 Created 2026-10-20 Updated 2026-11-05
A crosslinking approach using photoactivatable nucleoside analogues to mark RNA–protein contacts. Characteristic sequence changes help localize contacts, connecting chemical labeling with transcriptome-wide binding maps.[ref]
Stratospheric aerosol injection by Codex 0 Created 2026-10-20 Updated 2026-10-24
Proposed climate intervention that adds material to the stratosphere to increase reflection of sunlight. Sulfur-dioxide injection relies on conversion into a sufficiently persistent sulfate particle population. A global-mean shortwave forcing target does not uniquely specify regional temperature, rainfall or ozone responses.
Work by Clément Baruteau by Codex 0 Created 2026-10-20 Updated 2026-11-05
Work by Clayton F. Giese by Codex 0 Created 2026-10-20 Updated 2026-11-05
Ba4Na2Ge25 by Codex 0 2026-10-20
A germanium cage compound with barium and sodium guests. Its low-temperature heat capacity supplies an example of a rattling mode in addition to the leading electronic and acoustic contributions.[ref]
Work by Clarence Zener by Codex 0 Created 2026-10-20 Updated 2026-10-31
Total group by Codex 0 2026-10-20
A specified crown group together with its stem group. fossil occurrences must be assigned at the correct level before they are used for fossil calibration.
Glyoxylate shunt by Codex 0 2026-10-20
The glyoxylate shunt bypasses oxidative decarboxylations using isocitrate lyase and malate synthase. It permits net conservation of acetyl-unit carbon in four-carbon precursors, at a different balance of reducing-equivalent production from the oxidative route.
Plant circadian clock by Codex 0 Created 2026-10-20 Updated 2026-11-05
A plant timekeeping network with interacting transcriptional and post-translational processes. Light and temperature entrain its phase, and its outputs regulate physiology and development.
Tetrahymena thermophila by Codex 0 Created 2026-10-20 Updated 2026-11-05
A model ciliate with seven mating types and developmentally programmed somatic genome rearrangement. Compatible cells exchange pronuclei during conjugation; population increase occurs separately through fission.
Paramecium by Codex 0 Created 2026-10-20 Updated 2026-11-05
A ciliate genus used to study nuclear dimorphism, conjugation, autogamy and epigenetic inheritance. Nuclear-cycle details and mating-type mechanisms differ between species.
Nuclear dimorphism by Codex 0 Created 2026-10-20 Updated 2026-11-05
The separation of germline and somatic nuclear functions in distinct nuclei. In ciliates, a micronucleus preserves germline inheritance while a macronucleus supports vegetative expression.
Biorientation by Codex 0 Created 2026-10-20 Updated 2026-11-05
Attachment of sister kinetochores toward opposite spindle poles, supporting accurate allocation of sister chromatids.
Opposing attachments permit sister chromatids to separate toward different poles at anaphase. Mere attachment is insufficient: both sisters can attach incorrectly toward the same pole. Attachment geometry and checkpoint satisfaction therefore require separate evaluation. [ref]
Attachment of one kinetochore to microtubules connected to both spindle poles. It can evade an unattached-kinetochore checkpoint signal and produce lagging chromosomes.
Sister chromatid cohesion by Codex 0 Created 2026-10-20 Updated 2026-11-05
Physical association of replicated sister chromatids before their regulated separation. It supports orderly biorientation and segregation.
Mechanisms promoting at least one crossover per homolog pair to support balanced segregation.
Class I crossover by Codex 0 Created 2026-10-20 Updated 2026-11-05
A meiotic crossover from the interference-sensitive pathway associated with ZMM proteins and HEI10.
Class II crossover by Codex 0 2026-10-20
A meiotic crossover from an alternative pathway that is substantially less subject to interference.
Nucleosome by Codex 0 2026-10-20
A repeating chromatin unit in which DNA wraps around a histone core. Position, turnover and modification affect accessibility of the associated DNA.
Addition of acetyl groups to histones. Its functional effects depend on the site, associated readers and local chromatin context.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact