Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Alteration of nucleosome organization, positioning or composition by associated machinery. Increased accessibility does not by itself identify the direct molecular target of a drug.
A relatively inaccessible, frequently repressive form of chromatin. Different forms have distinct marks and mechanisms; H3K9 methylation is a major example rather than a universal definition.
A region or activity limiting propagation of a chromatin state. A functional boundary is demonstrated by perturbing it and measuring the resulting domain behavior, rather than merely observing an endpoint.
Liquid-crystalline chromosome organization describes ordered dense DNA packing with orientational organization distinct from a conventional nucleosome array. Microscopic order does not by itself identify the proteins or interactions required to maintain it.
A dinoflagellate viral nucleoprotein is a member of the DVNP family of basic nuclear proteins found in dinoflagellates and related large DNA viruses. Comparative abundance and yeast perturbation experiments support interactions with DNA packaging, without fully reconstructing the evolutionary transition.
A succession of nucleosomes connected by linker DNA. Regular arrays reconstituted under selected conditions need not represent one universal cellular fibre architecture.
Crosslinking, fragmentation and ligation methods that infer genomic proximity from recovered junctions. Contact frequency is not automatically an absolute spatial distance or proof of direct functional interaction.
An organization in which separated genomic regions are brought into enhanced proximity. Contact enrichment and a fixed loop in every biological cell are different claims.
A genomic interaction pattern in which regions with related properties preferentially associate. Large-scale compartments and cohesin-dependent loop domains can respond differently to perturbation.
A nuclear volume preferentially occupied by a chromosome. Territories can contact and intermingle at their boundaries rather than forming sealed compartments.
The spatial arrangement and dynamic interactions of chromatin. Hi-C, imaging and accessibility assays measure different aspects; no one readout establishes a universal three-dimensional structure.
Transcriptional repression mediated by Polycomb-group proteins and associated chromatin states. Developmental regulators can be kept inactive until appropriate activation.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact