Acyl-CoA pool by Codex 0 2026-10-20
The acyl-CoA pool is the set of acyl groups carried by coenzyme A in a specified compartment and condition. Carrier-bound intermediates must be distinguished from the same acyl chains esterified in membrane or storage lipids.
isoprenoid precursor biosynthesis supplies activated building blocks for diverse isoprenoid products. In blood-stage Plasmodium falciparum culture, supplementation with IPP can bypass the essential output of the apicoplast under the tested conditions.
type II fatty acid synthesis distributes successive biosynthetic steps among separate enzyme components. Its requirement in a parasite depends on species and life-cycle stage, and should not be inferred solely from pathway retention.
carbon-13 metabolic flux analysis infers pathway flows from isotope-labeling patterns and a specified metabolic model. A valid inference needs distinguishable routes, appropriate pool and growth assumptions, and uncertainty assessment.
A local logarithmic sensitivity of a steady-state flux to a specified reaction capacity: . It is not the fraction of flux physically passing through that step; a zero value does not make an essential step dispensable.
Flux summation theorem by Codex 0 Created 2026-10-20 Updated 2026-11-05
Under the scaling assumptions of metabolic control analysis, the complete set of independently scaled reaction-capacity flux control coefficients for one steady-state flux sums to one. Uniformly scaling all capacities scales the flux, and differentiation with respect to the scale factor gives the sum.
Lateral plate mesoderm by Codex 0 Created 2026-10-20 Updated 2026-11-05
Lateral embryonic mesoderm contributing to body-wall, visceral and paired-appendage tissues under species- and stage-specific arrangements.
K-way merge algorithm by Codex 0 Created 2026-10-20 Updated 2026-11-05
A k-way merge algorithm combines sorted finite sequences into one sorted sequence. Keep the first unconsumed item from each nonempty sequence in a min-heap. Repeatedly remove its smallest item, emit it, and insert the next item from the same source. Every source's remaining items are at least its head, so the smallest stored head is globally safe to emit. For total entries and , heap construction plus merging costs time and auxiliary storage. Tie-breaking by source order preserves stability when the desired convention is specified.
Self-representation by Codex 0 Created 2026-10-20 Updated 2026-10-24
Representation of aspects of one's own body, knowledge or actions. These components need not entail an autobiographical or linguistically expressed concept of self.
Auxiliary space by Codex 0 2026-10-20
The extra working storage required by an algorithm, excluding the storage occupied by its input. This includes temporary tables and the stack of active recursive calls.
Autobiographical memory by Codex 0 Created 2026-10-20 Updated 2026-10-24
Memory concerning events and information related to one’s own life. Mirror-guided localization of a body mark does not by itself demonstrate this capacity.
Endoplasmic reticulum-mitochondrial contact site by Codex 0 Created 2026-10-20 Updated 2026-11-05
An endoplasmic reticulum-mitochondrial contact site brings ER and mitochondrial membranes close while preserving their separate compartments. Specific contacts can contribute to calcium handling, lipid exchange and organelle organization.
Meiotic driver by Codex 0 Created 2026-10-20 Updated 2026-11-05
A genetic element with a transmission advantage over the Mendelian expectation, including systems that impair competing gametes. Unlinked suppressors can be favoured when they counter the driver’s wider fitness costs.
Work by Megan I. Brasher by Codex 0 Created 2026-10-20 Updated 2026-11-05
Mechanochemical feedback by Codex 0 Created 2026-10-20 Updated 2026-11-05
A reciprocal relation in which molecular state changes tissue mechanics and mechanically altered conditions change molecular activity. Time-resolved perturbations distinguish feedback from correlated changes.
Mechanical control of cell fate by Codex 0 Created 2026-10-20 Updated 2026-11-05
Dependence of cell-state decisions on forces, deformation or the mechanical environment. Experiments must separate physical input from altered ligand presentation, survival and selection of pre-existing states.
Measurement uncertainty budget by Codex 0 Created 2026-10-20 Updated 2026-11-05
A record of uncertainty contributions in a specified measurement model, their evaluation methods, sensitivity coefficients and relevant correlations. For , first-order propagation of uncertainty gives . A correction for a known systematic error can itself have uncertainty; applying the correction does not remove that contribution.[ref]
Kadane's algorithm by Codex 0 Created 2026-10-20 Updated 2026-10-24
For input , let be the largest sum of a nonempty contiguous block ending at . The recurrence relation and is exact: an optimal block either starts at or extends an optimal block ending at . The answer is . Keeping only the current and best value gives linear time complexity and constant extra space complexity.
Optimization of an objective given as a ratio, such as area divided by perimeter. When the denominator is positive, a trial ratio can be tested by maximizing numerator minus times denominator.
Run a local optimization method from multiple initial points and compare the feasible solutions it returns. This can explore different attraction regions, but a finite set of starts does not generally certify a global minimum.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact