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Researcher in intestinal stem cells. Snippert and collaborators investigated neutral competition among symmetrically dividing Lgr5-positive cells, connecting lineage replacement with tissue maintenance in the absence of an assumed fixed hierarchy.[ref]
Coauthor of research on signaling and loser-cell status during cell competition. The study connected sustained stress-related pathway activation with a cell’s relative disadvantage within a tissue.[ref]
Researcher in tissue morphogenesis. With Eric F. Wieschaus, Zallen investigated how patterned gene expression directs planar polarity in Drosophila, connecting embryonic pattern with orientation of cellular behavior.[ref]
Researcher in developmental patterning. Wolpert formulated positional information as a way to connect a cell’s location with its differentiation, separating the specification of a spatial value from the cell’s interpretation of it.[ref]
Positional information and the spatial pattern of cellular differentiation by Lewis Wolpert. Author list and described study
Portrait of Lewis Wolpert
. jmerelo. CC BY-SA 2.0, via Wikimedia Commons. Source.Researcher in regeneration. Maden investigated the effects of vitamin A on regenerating limbs, connecting a chemical perturbation with changes in positional pattern formation.[ref]
Vitamin A and pattern formation in the regenerating limb by Malcolm Maden. Author list and described study
Coauthor of research on cellular memory during axolotl limb regeneration. The study investigated retention of tissue-of-origin information, connecting regenerative capacity with constraints on lineage behavior.[ref]
Cells keep a memory of their tissue origin during axolotl limb regeneration by Martin Kragl and others. Author list and described study
Researcher in adult stem cells. Barker and collaborators identified intestinal and colonic stem cells using Lgr5, connecting a molecular marker with long-term tissue-producing capacity.[ref]
Coauthor of research on replacement of lost Lgr5-positive stem cells by their descendants. The study connected lineage plasticity with restoration of a stem-cell population after injury.[ref]
Coauthor of research on dedifferentiation of committed epithelial cells into stem cells in living tissue. The study connected tissue repair with reversal of a previously acquired developmental state.[ref]
Coauthor of research on the branching program of mouse lung development. The study connected a complex final anatomy with recurring patterns of branch formation during organ growth.[ref]
The branching programme of mouse lung development by Ross J. Metzger and others. Author list and described study
Coauthor of research on Hippo signaling and heart size. The study investigated inhibition of Wnt signaling and cardiomyocyte proliferation, connecting pathway interactions with control of organ growth.[ref]
Researcher in organoids. Sato and collaborators grew crypt–villus structures from individual Lgr5-positive stem cells, connecting a defined starting cell with self-organization of an intestinal tissue model.[ref]
Coauthor of experiments on SNARE complexes as minimal membrane-fusion machinery. Reconstitution tested what selected molecular components could achieve without the full complexity of a living cell.[ref]
SNAREpins: minimal machinery for membrane fusion by T. Weber and others. Author list and described study
Coauthor of research on selective activation of cognate SNARE complexes by Sec1/Munc18 proteins. The study connected recognition among fusion components with control of membrane fusion.[ref]
Selective activation of cognate SNAREpins by Sec1-Munc18 proteins by Jingshi Shen and others. Author list and described study
Coauthor of research linking syntaxin-4–Munc18 interactions with tumor invasion. The study connected trafficking of a membrane protease with the ability of cancer cells to remodel their surroundings.[ref]
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact