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A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice by Alexei A. Aravin and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Alexei A. Aravin.
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes by Toshiaki Watanabe and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Toshiaki Watanabe.
Nature 453, pp. 539–543. Small-RNA sequencing and Dicer/Ago2 loss establish endogenous siRNA roles in oocytes.
piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans by Alyson Ashe and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Alyson Ashe.
cell 150, pp. 88–99. Trigger removal and nuclear RNAi/chromatin mutants distinguish establishment from maintenance.
ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation by Daniel Zilberman and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
DNA-guided DNA interference by a prokaryotic Argonaute by Daan C. Swarts and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Daan C. Swarts.
Nature 507, pp. 258–261. Figures 1–4: plasmid restriction, DNA guides and Complementary DNA cleavage distinguish a bacterial defence system from RNA-guided RNA interference.
Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary by Colin D. Malone and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Colin D. Malone.
cell 137, pp. 522–535. Nine pathway mutants, small-RNA populations and Piwi localization distinguish germline and somatic ovarian pathways.
RNA polymerase IV directs silencing of endogenous DNA by A. J. Herr and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include A. J. Herr.
Science 308, pp. 118–120. NRPD1/NRPD2 perturbations connect a specialized polymerase, RDR2 and DCL3 to repeat silencing.
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos by Marta N. Shahbazi and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Marta N. Shahbazi.
Nature 552, pp. 239–243. Pluripotent-state manipulation and 3D imaging connect state exit to epithelial morphogenesis.
The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages by Gloria S. Kwon and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Gloria S. Kwon.
Developmental cell 15, pp. 509–520. Imaging and lineage labels demonstrate intercalation of epiblast-derived and visceral-endoderm-derived populations.
Feathered dinosaurs, flying dinosaurs, crown dinosaurs, and the name “Aves” by Jacques A. Gauthier and Kevin de Queiroz by
Codex 0 Created 2026-10-20 Updated 2026-10-31
A new phylogenetic data standard for computable clade definitions: the Phyloreference Exchange Format (Phyx) by Gaurav Vaidya and others by
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Cretaceous ornithurine supports a neognathous crown bird ancestor by Juan Benito and others by
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Evolution of the vomer and its implications for cranial kinesis in Paraves by Han Hu and others by
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Complete Ichthyornis skull illuminates mosaic assembly of the avian head by Daniel J. Field and others by
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Walk before you jump: new insights on early frog locomotion from the oldest known salientian by Andrés I. Lires and others by
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An Early Jurassic jumping frog by Neil H. Shubin and Farish A. Jenkins Jr. by
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Taphonomy and Population Dynamics of an Early Pliocene Vertebrate Fauna, Knox County, Nebraska by Michael R. Voorhies by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Fossilization of soft tissue in the laboratory by Derek E. G. Briggs and Amanda J. Kear by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Acanthodes and shark-like conditions in the last common ancestor of modern gnathostomes by Samuel P. Davis and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





