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Researcher in social evolution. With Robert Axelrod, Hamilton analyzed the evolution of cooperation through repeated interactions, connecting a formal strategic model with conditions under which cooperative behavior can persist.[ref]
The evolution of cooperation by Robert Axelrod and William D. Hamilton. Author list and described study
Coauthor of research on suppression of sex-ratio meiotic drive in Drosophila simulans. The study connected a biased inheritance system with an autosomal genetic suppressor.[ref]
Coauthor of research on interactions among honeybee workers and hormonal regulation of the division of labour. The study connected social contact with flexible changes in worker roles.[ref]
Coauthor of the xPore study identifying differential RNA modifications from direct nanopore sequencing. The method connected changes in measurement signals with comparisons of modification patterns between conditions.[ref]
Coauthor of research on METTL3 transcript variants. The study investigated alternative splicing as an explanation for apparently METTL3-independent RNA methylation, showing why a genetic perturbation must be checked for residual functional products.[ref]
Coauthor of the original spatial-transcriptomics study. The work connected expression measurements from tissue sections with their spatial organization, enabling molecular variation to be compared with tissue anatomy.[ref]
Coauthor of research on spatially resolved, highly multiplexed RNA measurements in individual cells. The work connected combinatorial labeling with simultaneous identification of many transcripts while retaining their positions.[ref]
Spatially resolved, highly multiplexed RNA profiling in single cells by Kok Hao Chen and others. Author list and described study
Coauthor of the iCLIP study. The work mapped RNA-protein contacts at individual-nucleotide resolution and connected binding patterns with effects on RNA splicing.[ref]
Coauthor of the eCLIP study. The method improved transcriptome-wide mapping of RNA-binding protein contacts, connecting biochemical isolation with controls needed to interpret enrichment at particular sequences.[ref]
Coauthor of the PAR-CLIP study mapping RNA-binding protein and microRNA target sites. The work connected experimentally marked RNA contacts with transcriptome-wide sequence measurements.[ref]
Researcher in optical microscopy. Denk and collaborators developed two-photon microscopy, connecting nonlinear excitation with localized fluorescence measurements in biological samples.[ref]
Two-photon laser scanning fluorescence microscopy by Winfried Denk and others. Author list and described study
Portrait of Winfried Denk
. External portrait hosted by Max-Planck-Gesellschaft. Source.Coauthor of the original STORM imaging study. The method reconstructed positions from stochastic fluorescent events, connecting localization of individual emitters with images beyond the ordinary diffraction limit.[ref]
Researcher in cellular imaging. Xu and collaborators identified a periodic arrangement of actin, spectrin and associated proteins in axons, connecting super-resolution observations with a previously unresolved cytoskeletal architecture.[ref]
Coauthor of experiments on importing stably folded proteins into peroxisomes. The study tested a distinctive organelle-targeting property by separating delivery from the assumption that every imported substrate must be unfolded.[ref]
Import of stably folded proteins into peroxisomes by P. A. Walton and others. Author list and described study
Coauthor of live-cell research on Golgi maturation. Following compartments over time connected changing molecular composition with the idea that a cisterna itself matures during transport.[ref]
Golgi maturation visualized in living yeast by Eugene Losev and others. Author list and described study
Coauthor of research on Rab conversion during endosome maturation. The study connected changing regulator identity with progression from early to late endosomal compartments.[ref]
Rab Conversion as a Mechanism of Progression from Early to Late Endosomes by Jochen Rink and others. Author list and described study
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact