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The variation of absorbed dose with depth for a specified beam, geometry and medium. A megavoltage photon beam has a secondary-electron buildup region followed by gradual dose reduction. A nearly monoenergetic proton beam instead exhibits a Bragg peak near the end of its range.

The dominant $z^2/{\beta }^2$ factor raises the energy loss as a charged projectile slows, while the logarithm moderates that rise. This produces a Bragg peak close to the end of its particle range. At still lower velocity, changing effective charge, shell effects and nuclear stopping invalidate extrapolation of the elementary Bethe stopping formula to zero energy. A finite initial energy gives a finite continuous-slowing-down range,A higher initial energy increases the particle range; greater electron density increases stopping power per unit length. Absorber $Z/A$ and $I$ also affect the depth. Multiple Coulomb scattering, energy-loss straggling, nuclear reactions and the incident energy spread broaden the measured peak and distal fall-off; nuclear secondaries can produce a small tail. Superposing many incident energies makes a spread-out Bragg peak for an extended target. The schematic curve below illustrates shapes only and is not patient radiation dosimetry.

Photon radiotherapy uses indirectly ionizing photons. Their Compton scattering, photoelectric effect and, at higher energy, pair production create charged particles that deposit energy. A megavoltage beam has a dose-build-up region followed by a gradual decline and substantial exit dose. Multiple shaped beams or intensity-modulated radiotherapy distribute this dose around a target.

Proton therapy uses directly ionizing charged particles with a finite particle range and a Bragg peak. Tuning beam energy controls depth and scanning controls lateral delivery; multiple energies cover a finite target thickness. Reduced distal and integral normal-tissue dose is a potential advantage. Limitations include range uncertainty, Multiple Coulomb scattering, nuclear secondary production, motion-dependent delivery, and a variable relative biological effectiveness, particularly near the distal edge. A physical dose advantage must be assessed against target coverage and clinically relevant toxicity; it does not by itself establish superior tumour control.

For a megavoltage X-ray beam, the surface absorbed dose is below the subsurface maximum. Photons generate energetic secondary electrons, mainly through Compton scattering; the downstream electron fluence initially builds up until approximate charged-particle equilibrium is established. Beyond this buildup region, decreasing primary photon fluence, scattering and geometric spreading make the depth-dose curve fall gradually. A penetrating photon beam has a substantial exit dose.

A nearly monoenergetic proton beam deposits a moderate entrance dose, then a sharp Bragg peak near the end of its range. As nonrelativistic protons slow, their electronic stopping power rises approximately as $1/v^2$ over the relevant part of the track. Once the protons stop, the dose falls steeply. Range straggling and energy spread broaden the peak; nuclear interactions add a smaller nonideal tail, so an exact hard cutoff is an idealization. Superposing appropriate incident energies produces a spread-out Bragg peak covering an extended target.^[ref]

The label MV for an X-ray treatment beam specifies the nominal accelerating potential of the electron accelerator. Its bremsstrahlung beam is a broad photon energy spectrum with an endpoint of order $eV$, not a monoenergetic beam whose individual photons all carry the quoted numerical energy. Proton therapy beam energies can instead be specified directly in MeV per incident proton.

Treatment using proton beams with controllable finite range and a Bragg peak. Potential normal-tissue sparing must be assessed against range uncertainty, motion and biological-effect uncertainties.

An extended high-dose depth interval formed by combining charged-particle beams of different ranges. The component Bragg peaks are weighted to cover a finite target thickness.