Use , a nonincreasing right-continuous survivor function. The empirical likelihood treats an exact event as a probability mass rather than maximizing an unrestricted probability density function at isolated data points. Under a noninformative observation mechanism, the event-time likelihood contributions are
The second, third and fourth rows account for right censoring, left censoring and interval censoring, respectively. A censoring mechanism with unknown dependence on cannot simply be dropped; these are the event-time factors under independent censoring or another ignorable mechanism.
There is a useful finite-dimensional reduction before optimization. Let be the set in which observation tells us its event time lies. Partition the time axis using all observed endpoints, keeping endpoint singletons when required. Within each cell, membership in every is constant. Assign cell masses , with , including a tail cell when necessary, and let be the cell-membership indicator. Then
Mass locations within a cell are not identifiable and need not be separate parameters. Repeated observation sets can be grouped and their factors raised to their counts. Cells with the same membership column can also be combined. If one column is componentwise dominated by another, transferring its mass to the dominating column weakly increases every factor; hence an unconstrained maximizing distribution can omit the dominated cell. This proves likelihood support reduction under censoring directly. The remaining log-likelihood is a concave function of the probability masses on a simplex, often far smaller than the original unrestricted distribution problem. Added constraints can restrict which transfers remain permissible.
For right censoring alone, take a grid of all distinct observation times and initially allow a discrete hazard
Let be the number of events at and the risk set immediately before that time. For tied recorded times, use the convention that events precede censoring, so those censored at remain in this risk set. The mass at is , and the probability of surviving past is . Substitution into the exact-event and right-censoring factors yields
The exponent counts all observed individuals whose information requires survival beyond that jump. In particular, censoring observations affect the risk set even though they give no event factor.
Each factor can now be maximized separately. For , its derivative is , giving ; the second derivative is negative. The same result holds at the boundaries: if , and if . The Kaplan–Meier estimator is therefore
Only event times contribute nontrivial factors. Residual mass after the last observation may be placed anywhere later without changing the empirical likelihood. A terminal plateau is therefore not evidence of permanent survival; the tail is unobserved.
For a constrained Kaplan–Meier estimator with , first split the support cells at . In the probability-mass representation the exact optimization problem is
The last sum excludes a singleton mass at , because . This is a concave maximization with linear equality constraints, so it directly gives a constrained nonparametric maximum-likelihood estimator. It also handles a time lying between observed events or beyond all follow-up.
An equivalent hazard formulation adds to the grid, permits zero-event jumps when needed, and imposes
For an interior solution using only positive-event jumps before , add to the log-likelihood. Differentiating gives
The multiplier is found by solving the scalar equation
with denominators and fitted hazards in their admissible ranges. On an admissible event-only interior branch, this product is increasing in , making a one-dimensional root search straightforward.
A constraint can require mass at a time with no observed event. The event-only multiplier equation must not be used blindly. To include boundary cases, put . Before , the constraint becomes , and each contribution is
For its multiplier equation again gives . For , its derivative is , so the maximum has when , and may have when . Such a jump supplies mass needed by the constraint; an unobserved tail with is included by the same rule. For example, if every observation is right-censored after and there are no events, the ordinary estimate has . To impose , put mass at and the remaining after all censoring times. The maximized likelihood is , although there are no event-time factors at all. The mass-constrained optimization above automatically accounts for this possibility and for any remaining tail nonuniqueness.
Condition on the bulb being alive at age . The next hour's survival likelihood contribution is
It does not depend on the unknown age . This is memorylessness of the exponential distribution: the residual lifetime given survival has the same exponential distribution as a new lifetime.
Condition on each patient's initial observed state and assume independent patient trajectories and observation times that do not carry additional information about the unobserved path. The Markov property factors each trajectory's likelihood function into its successive one-year transition probabilities. Thus
More explicitly, with and ,
Successive transitions within one patient need not be independent unconditionally: this is a product of conditional factors justified by the Markov property. If initial-state probabilities are modeled rather than conditioned on, their likelihood contributions must also be included. Zero-count terms contribute zero; a positive count attached to a zero model probability makes the log-likelihood equal to .
The four-parameter panel-observed multi-state likelihood requires the following additional assumptions.
  • Irreversibility: the chronic disease can progress but cannot improve, so and state 3 is absorbing. Merely permitting transitions between adjacent states does not impose this; allowing regression would require additional transition intensities.
  • Piecewise-constant age: the current age is held at 50 and 55 over the respective observation intervals. Actual age changes continuously, and a five-year interval can be too long for this approximation when the age effect is substantial.
  • Log-linear age effects and common rates: the specified age functions apply to the patient, without unmodelled heterogeneity or other changing covariates.
  • Observation mechanism: disease states are recorded without misclassification, and examination times or dropout carry no additional information about the underlying process once the modelled history is given. A new visit only one year after a five-year gap might have been prompted by worsening symptoms, making the observation schedule informative.
If age is instead updated continuously, the model is time-inhomogeneous and the displayed homogeneous transition formula is not exact. For example, set
Then the exact irreversible likelihood contribution is
Thus the simple closed form uses an explicit frozen-age approximation; adjacency alone and continuously evolving age do not determine that form.
Use an irreversible continuous-time multi-state model , with state 3 absorbing. Let and , and define log-linear age effects by
For a closed-form panel-observed multi-state likelihood, freeze the age covariate at the start of each observation interval. The transition intensities are then over the first interval and over the second. Conditional on the initial state, the likelihood contribution is
Indeed, and . In this irreversible continuous-time Markov chain, the intermediate state has probability
The second expression is the continuous limit of the first and handles equal rates. The observed two-state jump across an interval is compatible with adjacent instantaneous transitions: an unobserved visit to state 2 occurs between the examinations.
Assume a negative test identifies the recovered state. Person 1 remains infected through day 7 and recovers during , so their interval-censored contribution is
Person 2 remains infected through day 7 and makes an exact transition at day 10. A transition at an exact time contributes a transition probability density, giving
Assuming independent individuals, their joint likelihood contribution is