The precision matrix is the inverse of a nonsingular covariance matrix. For a multivariate normal distribution, a zero off-diagonal precision entry encodes conditional independence of the corresponding coordinates given all remaining coordinates.
For a nonsingular multivariate normal distribution with precision matrix , fixing all coordinates except leaves a density proportional to after completing the square. Thus its conditional variance is the reciprocal diagonal precision entry. This is conditioning on every other coordinate, not the marginal variance .
In a Gaussian graphical model, regressing component on the others gives the displayed coefficients, residual variance and intercept . Opposite directions have identical zero patterns and signs because is symmetric with positive diagonal, but generally unequal coefficient magnitudes.
For independent multivariate normal observations with unknown mean and nonsingular covariance, profiling the mean at its sample value gives negative log-likelihood proportional to over . The sample covariance matrix uses divisor . Its minimizer exists exactly when , and is then .
If a positive-definite matrix is the precision matrix of a multivariate normal distribution, draw independent and solve . Then has covariance . This avoids forming the inverse and exploits a banded Cholesky decomposition when is banded.
The constrained minimization estimator minimizes subject to
Its constraints and objective separate by columns. Feasibility of the true precision matrix and elementary matrix-norm inequalities yield entrywise error bounds under an entrywise covariance-estimation bound.
The graphical Lasso estimates a sparse precision matrix by minimizing a Gaussian negative log-likelihood plus an entrywise penalty.
For a Graphical Lasso solution with inverse , the unique minimizer of , , is . The inverse identity gives , and the off-diagonal Graphical-Lasso Karush-Kuhn-Tucker conditions become the column Lasso conditions because the corresponding signs are opposite.
For objective , the KKT conditions are with .

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