Dynamic binding in chemistry refers to the process where molecules, such as ligands and receptors or substrates and enzymes, interact with each other in a reversible manner. This interaction can change over time, allowing for the binding and unbinding of the molecules involved. This concept is particularly relevant in fields such as biochemistry, supramolecular chemistry, and materials science.
Bonaventura Clotet is a prominent Spanish scientist, physician, and researcher, particularly known for his work in the fields of HIV/AIDS and infectious diseases. He has contributed significantly to the understanding and treatment of HIV infection and related conditions. Clotet has been involved in clinical research and has held various academic and leadership positions in institutions focused on infectious diseases. His work has not only advanced medical knowledge but also improved patient care and treatment strategies in HIV/AIDS.
The Grunwald-Winstein equation is a notable relationship in organic chemistry that relates the solvent effects on the rates of nucleophilic substitution reactions, particularly those involving substrates that undergo unimolecular nucleophilic substitution (S_N1) and bimolecular nucleophilic substitution (S_N2) mechanisms.
The Hammett equation is a mathematical expression used in physical organic chemistry to relate reaction rates and equilibrium constants of reactions involving substituted aromatic compounds to the electronic effects of the substituents. It provides a quantitative measure of how substituents (such as -NO2, -Cl, -CH3, etc.) influence the reactivity of the aromatic compound in electrophilic or nucleophilic reactions.
Blackett Laboratory is a research facility associated with Imperial College London, located in South Kensington, London. It is primarily known for its work in engineering and physics, particularly in the fields of nuclear science, particle physics, and materials science. The laboratory is named after Patrick Blackett, a prominent physicist and Nobel laureate who made significant contributions to experimental physics. The facility includes various research groups, laboratories, and equipment for conducting experiments and advancing knowledge in both theoretical and applied sciences.
Möbius aromaticity refers to a unique type of aromaticity that arises in certain cyclic, conjugated systems that have a Möbius topology, typically characterized by having a twisted, half-twist (or Möbius) structure. This is in contrast to traditional planar aromatic systems, which follow Hückel's rule, stating that a cyclic compound is aromatic if it has \( 4n + 2 \) π electrons (where \( n \) is a non-negative integer).
Negative hyperconjugation refers to a phenomenon in organic chemistry where electron donation occurs from a filled p orbital or lone pair on a substituent to a π* (pi anti-bonding) orbital of a neighboring bond, such as a carbon-carbon double bond or a carbon-heteroatom bond. This process leads to a stabilization of the system by delocalizing the electrons across the molecule.
The Woodward–Hoffmann rules are a set of principles used in organic chemistry to predict the outcome of pericyclic reactions, which are reactions that involve cyclic transition states and occur via a concerted mechanism (simultaneous bond-breaking and bond-forming processes). Named after chemists Robert Burns Woodward and Donald Albert Hoffmann, these rules provide a framework to determine whether a pericyclic reaction is thermally allowed or forbidden based on molecular orbital (MO) theory.
José Baselga was a prominent Spanish oncologist and researcher, known for his significant contributions to the field of cancer treatment and research, particularly in breast cancer and targeted therapies. He held key positions in various prestigious institutions, including serving as the physician-in-chief at Memorial Sloan Kettering Cancer Center in New York and working as a leader in the pharmaceutical industry, particularly at AstraZeneca.
"Gravitation" is a comprehensive textbook on gravitational physics, co-authored by Charles W. Misner, Kip S. Thorne, and John Archibald Wheeler. First published in 1973, it is often regarded as a classic in the field of general relativity and gravitational physics. The book provides an in-depth exploration of the concepts and mathematical formulations of Einstein's theory of general relativity, as well as its applications to various physical phenomena.
Georges-Louis Le Sage was an 18th-century Swiss physicist and philosopher, born on June 16, 1724, and he passed away on August 2, 1803. He is best known for his work in the fields of gravity and atomic theory. Le Sage is particularly noted for proposing a mechanical explanation of gravity, often referred to as the "Le Sage theory of gravitation.
The Department of Physics and Astronomy at the University of Manchester is an academic department dedicated to research and education in the fields of physics and astronomy. It is part of the University of Manchester, which is known for its strong emphasis on research and has a rich history in these scientific disciplines. The department offers undergraduate and postgraduate programs that cover a wide range of topics, including theoretical physics, experimental physics, astrophysics, and cosmology, among others.
"Six nines" in the context of the digits of pi refers to a sequence of six consecutive 9s. The first occurrence of the sequence "999999" in the decimal expansion of pi starts at the 762nd decimal place. The decimal representation of pi begins as follows: 3.1415926535...
A piezoelectric accelerometer is a type of sensor that measures acceleration or vibration by utilizing the piezoelectric effect. The piezoelectric effect is the ability of certain materials to generate an electrical charge in response to mechanical stress.
"Structure and Interpretation of Classical Mechanics" (often abbreviated as SICM) is a textbook co-authored by Gerald Jay Sussman and George J. Hachtel. Published in 2001 as part of the MIT Press series, it serves as an introduction to classical mechanics via a unique and conceptual approach that emphasizes the underlying principles and structure of the subject. The book takes a highly methodical perspective, using a variety of computational and mathematical tools.
The computation of π (pi) has a long and fascinating history that spans thousands of years. Here's a chronology highlighting significant milestones in the calculation of π: ### Ancient Civilizations - **c. 2000 BCE**: Egyptians and Babylonians estimated π as 3.16 and 3.125, respectively. The Rhind Mathematical Papyrus suggests a value of approximately 3.16. - **c.
Here is a list of notable mathematical formulae and constants involving π (pi): 1. **Circumference of a Circle**: \[ C = 2\pi r \] where \( C \) is the circumference and \( r \) is the radius of the circle.
Milü, often referred to as "Milu" or "Milü deer," is a species of deer known scientifically as *Elaphurus davidianus*. It is native to eastern Asia, particularly China, and is known for its distinctive appearance, which includes large antlers and a striking coat. The Milü is notable for its long, slender legs and adaptations to wetland habitats.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact