Technique widely used to measure the size of DNA strands, most often PCR output of a region of interest.
A simple sample application is gel electrophoresis alelle determination.
In the case of indel mutations (see limits of gel electrophoresis for minimal size difference issues), it is possible to determine the allele with gel electrophoresis. You can just read out the alleles right in the gel. It is a thing of beauty.
As of 2020, this method appears to be much cheaper than DNA sequencing approaches.
Gel Electrophoresis to Determine Genotype
. Source. - 1982 www.pnas.org/doi/pdf/10.1073/pnas.80.6.1579 DNA fragments differing by single base-pair substitutions are separated in denaturing gradient gels by Fischer and Lerman (1982). It is possible then.
These can be used to break cells apart from tissue, and also break up larger DNA or RNA molecules into smaller ones, suitable for sequencing.
This was the first full scale nuclear reactor in the world, and was brought up slowly to test it out.
Hanford B Reactor tour by Studio McGraw
. Source. 2016.- youtu.be/8rlVHEY7BF0?t=335 good description of the fuel element. It uses uranium metal, not Uranium dioxide
- youtu.be/8rlVHEY7BF0?t=652 N Reactor and F Reactor were identical, and came up 2 months later, but much faster because of what they learned on the B
Ciro Santilli intends to move his beauty list here little by little: github.com/cirosantilli/mathematics/blob/master/beauty.md
The most beautiful things in mathematics are results that are:
- simple to state but hard to prove:
- Fermat's Last Theorem
- number of unknown rationality, e.g. is rational?
- transcendental number conjectures, e.g. is transcendental?
- basically any conjecture involving prime numbers:
- many combinatorial game questions, e.g.:
- surprising results: we had intuitive reasons to believe something as possible or not, but a theorem shatters that conviction and brings us on our knees, sometimes via pathological counter-examples. General surprise themes include:Lists:
- classification of potentially infinite sets like: compact manifolds, etc.
- problems that are more complicated in low dimensions than high like:
- generalized Poincaré conjectures. It is also fun to see how in many cases complexity peaks out at 4 dimensions.
- classification of regular polytopes
- unpredictable magic constants:
- why is the lowest dimension for an exotic sphere 7?
- why is 4 the largest degree of an equation with explicit solution? Abel-Ruffini theorem
- undecidable problems, especially simple to state ones:
- mortal matrix problem
- sharp frontiers between solvable and unsolvable are also cool:
- attempts at determining specific values of the Busy beaver function for Turing machines with a given number of states and symbols
- related to Diophantine equations:
- applications: make life easier and/or modeling some phenomena well, e.g. in physics. See also: explain how to make money with the lesson
Good lists of such problems Lists of mathematical problems.
Whenever Ciro Santilli learns a bit of mathematics, he always wonders to himself:Unfortunately, due to how man books are written, it is not really possible to reach insight without first doing a bit of memorization. The better the book, the more insight is spread out, and less you have to learn before reaching each insight.
Am I achieving insight, or am I just memorizing definitions?
There are two ways:
- manually dumping your brain on media such as notebooks, wikis or videos, i.e. forming a personal knowledge base
- technically using sensors for brain scanning
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.
Figure 4. Visual Studio Code extension tree navigation.
Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact