The following things come to mind when you look into research in this area, especially the search for BB(5) which was hard but doable:
- it is largely recreational mathematics, i.e. done by non-professionals, a bit like the aperiodic tiling. Humbly, they tend to call their results lemmas
- complex structure emerges from simple rules, leading to a complex classification with a few edge cases, much like the classification of finite simple groups
Bibliography:
Turing machine acceleration refers to using high level understanding of specific properties of specific Turing machines to be able to simulate them much fatser than naively running the simulation as usual.
Acceleration allows one to use simulation to find infinite loops that might be very long, and would not be otherwise spotted without acceleration.
This is for example the case of www.sligocki.com/2023/03/13/skelet-1-infinite.html proof of Skelet machine #1.
Just like the adenine nucleotide translocator moves ATP/ADP in and out, this one moves loose phosphate in.
Both of those together recycle the cellular respiration carriers from/to the mitochondria.
Project trying to compute BB(5) once and for all. Notably it has better presentation and organization than any other previous effort, and appears to have grouped everyone who cares about the topic as of the early 2020s.
Very cool initiative!
By 2023, they had basically decided every machine: discuss.bbchallenge.org/t/the-30-to-34-ctl-holdouts-from-bb-5/141
The last value we will likely every know for the busy beaver function! BB(6) is likely completely out of reach forever.
By 2023, it had basically been decided by the The Busy Beaver Challenge as mentioned at: discuss.bbchallenge.org/t/the-30-to-34-ctl-holdouts-from-bb-5/141, pending only further verification. It is going to be one of those highly computational proofs that will be needed to be formally verified for people to finally settle.
As that project beautifully puts it, as of 2023 prior to full resolution, this can be considered the:on the Busy beaver scale.
simplest open problem in mathematics
Good animation explaining it: Video "Electron transport chain by HarvardX (2017)".
Best busy beaver machine known since 1989 as of 2023, before a full proof of all 5 state machines had been carried out.
Paper extracted to HTML by Heiner Marxen: turbotm.de/~heiner/BB/mabu90.html
Non formal proof with a program March 2023: www.sligocki.com/2023/03/13/skelet-1-infinite.html Awesome article that describes the proof procedure.
The proof uses Turing machine acceleration to show that Skelet machine #1 is a Translated cycler Turing machine with humongous cycle paramters:
If you can reduce a mathematical problem to the Halting problem of a specific turing machine, as in the case of a few machines of the Busy beaver scale, then using Turing machine deciders could serve as a method of automated theorem proving.
That feels like it could be an elegant proof method, as you reduce your problem to one of the most well studied representations that exists: a Turing machine.
However it also appears that certain problems cannot be reduced to a halting problem... OMG life sucks (or is awesome?): Section "Turing machine that halts if and only if Collatz conjecture is false".
bbchallenge.org/story#what-is-known-about-bb lists some (all?) cool examples,
- BB(15): Erdős' conjecture on powers of 2, which has some relation to Collatz conjecture
- BB(27): Goldbach's conjecture
- BB(744): Riemann hypothesis
- BB(748): independent from the Zermelo-Fraenkel axioms
- BB(7910): independent from the ZFC
wiki.bbchallenge.org/wiki/Cryptids contains a larger list. In June 2024 it was discovered that BB(6) is hard.
Turing machine that halts if and only if the Goldbach conjecture is false by 
Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli 40 Updated 2025-07-16 Turing machine that halts if and only if Collatz conjecture is false by Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli 40 Updated 2025-07-16mathoverflow.net/questions/309044/is-there-a-known-turing-machine-which-halts-if-and-only-if-the-collatz-conjectur suggests one does not exist. Amazing.
Intuitively we see that the situation is fundamentally different from the Turing machine that halts if and only if the Goldbach conjecture is false because for Collatz the counter example must go off into infinity, while in Goldbach conjecture we can finitely check any failures.
Amazing.
A problem that has more than two possible yes/no outputs.
Ciro Santilli believes that molecular biology technologies will be a large part of the next big things as shown at: Section "Molecular biology technologies".
Bibliography:
- www.youtube.com/watch?v=mS563_Teges&list=PLQbPquAyEw4dQ3zOLrdS1eF_KJJbUUyBx Biophysical Techniques Course 2022 by the MRC Laboratory of Molecular Biology. Holy crap that playlist is a tour de force of molecular biology techniques in 2022!
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.
Figure 4. Visual Studio Code extension tree navigation.
Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact