Using de novo DNA synthesis to synthesize a genes to later insert somewhere.
Note that this is a specific application of de novo DNA synthesis, e.g. polymerase chain reaction primers is another major application that does not imply creating genes.
After breaking production and sweating for a bit hotfixing (not that anyone uses the website yet), I decided to be smart and created a staging server: ourbigbook-staging.herokuapp.com. Now I can blow that server up as I wish without afecting users. Documented at: cirosantilli.com/ourbigbook/staging-deployment
Type of RNA by Ciro Santilli 40 Updated 2025-07-16
The most important ones are:
In the context of "The Big Bang Theory," Pilot refers to the first episode of the popular television sitcom, which aired on September 24, 2007. In this episode, viewers are introduced to the main characters, including Sheldon Cooper, Leonard Hofstadter, Penny, Howard Wolowitz, and Rajesh Koothrappali. The plot centers around Leonard and Sheldon, two physicists who struggle with social interactions, particularly with their new neighbor, Penny, an aspiring actress.
"The Egg Salad Equivalency" is a concept from the popular online forum and community called "Reddit." Specifically, it originates from the subreddit r/Showerthoughts, where users share insightful or humorous observations about everyday life. The term "Egg Salad Equivalency" refers to the notion that many mundane or seemingly trivial tasks or decisions can be compared in terms of their importance or relevance to one's life.
The Jordan Curve Theorem is a fundamental result in topology, a branch of mathematics that studies properties of spaces that are preserved under continuous deformations. The theorem states that any simple closed curve in a plane (a curve that does not intersect itself and forms a complete loop) divides the plane into two distinct regions: an "inside" and an "outside.
The Dold–Kan correspondence is a fundamental theorem in algebraic topology and homological algebra that establishes a relationship between two important categories: the category of simplicial sets and the category of chain complexes of abelian groups (or modules). It is named after mathematicians Alfred Dold and D. K. Kan, who formulated it in the context of homotopy theory.
The Oka coherence theorem is a result in complex analysis and several complex variables, particularly in the field of Oka theory. Named after Shinsuke Oka, this theorem deals with the properties of holomorphic functions and their extensions in certain types of domains.
The Master Theorem is a powerful tool in the analysis of algorithms, particularly for solving recurrences that arise in divide-and-conquer algorithms. It provides a method for analyzing the time complexity of recursive algorithms without having to unroll the recurrence completely or use substitution methods.
The "No Free Lunch" (NFL) theorem in the context of search and optimization is a fundamental result that asserts that no optimization algorithm performs universally better than others when averaged over all possible problems. Introduced by David Wolpert and William Macready in the 1990s, the theorem highlights a crucial insight in the field of optimization and search algorithms. ### Key Concepts of the No Free Lunch Theorem 1.
Claus Emmeche is a Danish biologist known for his work in various fields, including philosophy of biology, cognitive science, and the study of complex systems. He has contributed to discussions about the nature of life, the relationship between biology and philosophy, and the implications of biological research for understanding consciousness and cognition. Emmeche has published several scholarly articles and has been involved in interdisciplinary research projects that bridge the gap between science and philosophy.
Meredith Gwynne Evans is not widely recognized in public databases or notable records as of my last update. It is possible that they are a private individual or not prominent in mainstream media or historical references.
In computational complexity theory, the class PH (short for "Polynomial Hierarchy") is a way of categorizing decision problems based on their complexity relative to polynomial-time computations. It is a hierarchy of complexity classes that generalizes the class NP (nondeterministic polynomial time) and co-NP (problems whose complements are in NP). The polynomial hierarchy is defined using alternating quantifiers and is composed of multiple levels, where each level corresponds to a certain type of decision problem.
Rounding is a mathematical technique used to simplify a number by reducing the number of digits while maintaining a value that is approximately equivalent to the original number. This process is commonly applied to make calculations easier or to present numbers in a more digestible form. The rules of rounding generally involve looking at the digit immediately to the right of the place value you want to round to: 1. **If that digit is less than 5**, you round down (leave the target place value as is).
As of my last knowledge update in October 2023, there is no widely known figure or concept specifically known as "James Renegar" that has gained significant recognition in literature, media, or popular culture. It's possible that you may be referring to an individual who is not broadly covered or a subject that has emerged after that date.
Alan Cobham (1906–1973) was a notable British mathematician and computer scientist, best known for his contributions to the fields of numerical analysis and computational mathematics. Cobham is particularly recognized for his work on algorithm design and complexity, including the formulation of what is now referred to as "Cobham's theorem," regarding the complexity of number-theoretic functions. His research extended into various areas, including automatic computation and type theory, and he was influential in early computing development.
As of my last knowledge update in October 2023, there isn't a widely recognized figure or entity specifically known as Dan Hirschberg. It's possible that he may be a private individual, a lesser-known public figure, or a name in a specific industry not broadly covered in popular sources.
Donald B. Johnson could refer to various individuals, depending on the context. For instance, he may be a notable figure in a specific field such as science, politics, or entertainment. However, without additional context, it's difficult to provide a specific answer. If you are asking about a particular person or entity named Donald B.
Eli Shamir is a name that may refer to various individuals, but in the context of academia and mathematics, Eli Shamir is an Israeli mathematician known for his work in areas such as optimization and mathematical modeling.
Gary Miller is a prominent computer scientist known for his contributions to the fields of algorithms and computational geometry. He is recognized for his work on various algorithms and theoretical aspects of computer science, including topics such as graph theory, parallel computing, and optimization. Miller has been associated with several academic institutions throughout his career, including positions at the Georgia Institute of Technology. He has published numerous papers and contributed to the development of important concepts within computer science.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact