CLIC6, or Chloride Intracellular Channel protein 6, is a protein that belongs to the CLIC (Chloride Intracellular Channel) family of proteins. These proteins are characterized by their ability to form ion channels that are selective for chloride ions, which play important roles in various cellular processes, including maintaining the cell's electrochemical gradient, regulating cell volume, and signaling. CLIC6 is involved in several physiological and pathological processes.
KCNK5, also known as "Potassium Channel, Two-Pore Domain, Subfamily K, Member 5," is a gene that encodes a protein involved in the formation of a specific type of potassium ion channel. These channels are integral in various physiological processes, including setting the resting membrane potential of cells, regulating excitability, and contributing to the overall homeostasis of potassium ions within cells.
Cav1.4 refers to a specific type of voltage-gated calcium channel, which is part of the Cav1 family of channels. These channels are crucial for the influx of calcium ions (Ca²⁺) into cells in response to membrane depolarization. Cav1.4 is primarily found in the retina, particularly in photoreceptor cells (such as rods and cones) and some bipolar cells. Key features of Cav1.
KCNA10, or Potassium Voltage-Gated Channel Subfamily A Member 10, is a protein that in humans is encoded by the KCNA10 gene. This protein is a member of the voltage-gated potassium channel family, which plays critical roles in the electrical excitability of cells, including those in the heart and nervous system.
KCNG4, or "Potassium Voltage-Gated Channel Subfamily G Member 4," is a gene that encodes a protein belonging to the family of voltage-gated potassium channels. These channels are essential for the regulation of electrical signaling in tissues, particularly in the nervous system and muscle tissues. KCNG4 is specifically known for its role in the transmission of electrical impulses across cell membranes.
KCNAB3 refers to a gene that encodes a protein called potassium voltage-gated channel subfamily A member 3. This protein is a part of the larger family of potassium channels, which are critical for various physiological processes, including the regulation of cardiac, neuronal, and muscle excitability. The KCNAB3 protein functions as an auxiliary subunit that can influence the properties of voltage-gated potassium channels, such as their conductance, kinetics, and membrane localization.
KCNK6, also known as TWIK-related K+ channel 6, is a gene that encodes a protein belonging to the two-pore domain potassium channel (K2P) family. These channels are known for their role in maintaining the resting membrane potential and regulating the excitability of neurons and other cells by allowing potassium ions (K+) to flow across the cell membrane. KCNK6 is characterized by its ability to contribute to the background potassium conductance in various tissues.
KCNE4 is a gene that encodes a protein belonging to the KCNE family of potassium channel accessory subunits. These proteins are known to modulate the function of voltage-gated potassium channels, influencing their gating properties, conductance, and localization. Specifically, KCNE4 is associated with the modulation of ion flow and plays a role in various physiological processes, including the regulation of cardiac rhythm and other electrical activities in cells.
KCNJ15 is a gene that encodes a member of the potassium channel family, specifically belonging to the inwardly rectifying potassium (KIR) channels. These channels are integral membrane proteins that play a critical role in regulating the cell's membrane potential and, consequently, various physiological processes, including the regulation of heart rhythm, muscle contraction, and neuronal excitability. In particular, KCNJ15 is involved in the regulation of potassium ions (K+) across the cell membrane.
P2RX4 is a gene that encodes the protein P2X purinoceptor 4, which is part of the purinergic receptor family. These receptors are ion channels activated by extracellular ATP (adenosine triphosphate). P2X4 is a trimeric receptor, meaning that it forms a channel by assembling three identical subunits.
KCNJ8 is a gene that encodes a protein known as the potassium ion channel, specifically the K(ATP) channel, which is sensitive to intracellular ATP levels. This channel plays a crucial role in regulating cellular excitability, particularly in muscle and neuronal tissues. KCNJ8 is part of the inwardly rectifying potassium channel family and is typically associated with controlling various physiological processes, including insulin secretion in pancreatic beta cells, vascular smooth muscle contraction, and cardiac action potentials.
N-type calcium channels, also known as Cav2.2 channels, are a type of voltage-gated calcium channel that play a critical role in various physiological processes. These channels are primarily found in neurons and are responsible for facilitating the influx of calcium ions (Ca²⁺) into cells in response to membrane depolarization.
KCNT1 is a gene that encodes a type of potassium ion channel, specifically a member of the Slo-related (also known as K_Ca or K-channel) family of potassium channels. These channels play critical roles in regulating various physiological processes, including neuronal excitability, muscle contraction, and the cardiac action potential.
Ryanodine receptor 2 (RyR2) is a type of intracellular calcium release channel found primarily in cardiac muscle cells. It is part of the ryanodine receptor family, which also includes other isoforms such as RyR1 (predominantly found in skeletal muscle) and RyR3 (found in various tissues). RyR2 plays a crucial role in the regulation of calcium ions (Ca²⁺) in the heart, which is essential for muscle contraction and relaxation.
A Liquid Metal Ion Source (LMIS) is a type of ion source used primarily in various applications such as mass spectrometry, focused ion beam (FIB) systems, and ion implantation. The LMIS generates ions by the field evaporation or field ionization of a liquid metal that is contained in a small source chamber.
KCNQ channels, also known as M-type potassium channels, are a family of voltage-gated potassium channels that are encoded by the KCNQ gene family. These channels play a crucial role in regulating neuronal excitability and are important for setting the resting membrane potential and shaping action potentials in neurons and other excitable cells.
KCNS2 is a gene that encodes a type of potassium channel known as a voltage-gated potassium channel. Specifically, the protein produced by this gene is known as the potassium voltage-gated channel subfamily S member 2. These channels play a crucial role in maintaining the electrical potential across the cell membrane and are involved in various physiological processes, including the regulation of neuronal excitability, muscle contraction, and cardiac rhythm.
TRPN, or Transient Receptor Potential N-Methyl-D-Aspartate (NMDA) receptor Potentiating Protein, is a protein that is part of a family of transient receptor potential (TRP) channels. These channels are known for their role in various physiological processes, including sensory perception, pain, and thermoregulation. In the context of TRPN channels, they are involved in various cellular signaling pathways and can respond to different stimuli, such as temperature changes.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.Figure 4. Visual Studio Code extension tree navigation.Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





