A Backbone-dependent rotamer library is a collection of pre-computed side-chain conformations (rotamers) for amino acids that take into account the influence of the protein backbone on the orientation and flexibility of the side chains. In protein structures, the side-chain conformation of amino acids can be significantly affected by their environment, particularly by the dihedral angles of the backbone.
Biological data refers to any data that is derived from biological systems, organisms, or processes. It encompasses a wide range of information related to the structure, function, and interactions of biological molecules, cells, tissues, organisms, and ecosystems. This type of data can be collected from various sources and can be used for a multitude of research and application purposes, including genomics, proteomics, ecology, medicine, and more.
CASP can refer to several things, depending on the context. Below are a few of the most common meanings: 1. **Certified Advanced Security Practitioner (CASP)**: In the field of information technology, CASP is a certification offered by CompTIA. It is designed for advanced IT professionals who want to demonstrate their skills in enterprise security, risk management, and advanced security solutions.
Critical Assessment of Function Annotation (CAFA) is an evaluation initiative designed to assess the accuracy and effectiveness of computational methods for predicting the function of proteins. Established in 2010, CAFA serves as a benchmark for evaluating how well computational models can predict biological functions based on sequence or structural data. The main aspects of CAFA include: 1. **Data Input**: The initiative uses a large set of proteins with well-characterized functions.
HubMed is a specialized search engine designed for accessing and searching the medical literature, primarily focused on biomedical and life sciences. It was created to provide more refined search capabilities compared to general search engines and even some traditional databases. Users can search for articles, abstracts, and other resources from a variety of medical journals and publications. The platform allows users to customize their searches using features like filters, tags, and personalized collections, making it easier to find relevant research content quickly.
Fluxomics is a sub-discipline of metabolomics that focuses on studying the rates of metabolic reactions within a biological system. It aims to measure and analyze the flow of metabolites through various metabolic pathways to understand how cells and organisms produce and utilize energy and biomass. By examining fluxes rather than just the concentrations of metabolites, fluxomics provides insights into metabolic dynamics, regulation, and interactions among metabolic pathways.
GC skew is a metric used to analyze the relative abundance of guanine (G) and cytosine (C) nucleotides in a segment of DNA. It is calculated to identify regions of DNA that may differ in their GC content, which can have implications for understanding genomic features, such as replication origins, gene density, and overall genomic stability.
As of my last update, "Infologs" could refer to various concepts or brands, depending on the context. However, it's often associated with data management, information logging, or analytics platforms that help organizations manage and analyze their data more effectively.
Here is a list of some prominent bioinformatics journals where researchers publish their findings related to the field: 1. **Bioinformatics** - A leading journal in the field, covering algorithms, computational methods, and software tools for analyzing biological data. 2. **BMC Bioinformatics** - An open-access journal that publishes research on algorithms, software, and techniques used in bioinformatics.
SAM (Sequence Alignment/Map) is a file format used to store biological sequences aligned to a reference genome. It is a crucial format in bioinformatics, particularly in the analysis of next-generation sequencing (NGS) data. SAM files are text-based and represent read alignments in a tabular format, allowing for easy handling and manipulation.
Transcription factor binding site databases are specialized repositories that catalog the binding sites of transcription factors (TFs) across various species and biological contexts. These databases are crucial for understanding gene regulation, as transcription factors are proteins that bind to specific DNA sequences to regulate the transcription of target genes. Here's a brief overview of what transcription factor binding site databases typically include: 1. **Data on Binding Sites**: They collect and curate information about the specific DNA sequences (binding sites) where transcription factors attach.
An algal bloom is a rapid increase in the population of algae in water bodies, such as oceans, lakes, and rivers. These blooms can occur in both freshwater and marine environments and are often characterized by a noticeable change in the color of the water, which can take on shades of green, blue, red, or brown, depending on the type of algae involved.
LilyPond is a music engraving program designed to produce high-quality sheet music. It is often used by composers, arrangers, and musicians for creating musical scores in a typeset format. The main features of LilyPond include: 1. **Text-based input**: Users write music in a plain text format using a custom notation language, which allows for precise control over the layout and formatting of the score.
Lignocellulosic biomass refers to plant biomass that is composed primarily of three main structural components: cellulose, hemicellulose, and lignin. These components form the cell walls of plants and contribute to their structural integrity. Here's a brief overview of each component: 1. **Cellulose**: This is a polysaccharide made up of glucose units linked together, and it is the main component of the plant cell wall. Cellulose provides rigidity and strength to the plant structure.
Neurophysins are a group of proteins that are associated with the transport and storage of neuropeptides, specifically oxytocin and vasopressin. They are highly concentrated in the posterior pituitary gland, where these neuropeptides are secreted into the bloodstream. Neurophysins are synthesized in the hypothalamus as part of larger precursor proteins called neurophysin-oxytocin and neurophysin-vasopressin.
Inlets is an open-source tool that enables the exposure of local services to the internet. It is often used in cloud-native and microservice architectures for scenarios where a developer needs to share a local application or service over the web without deploying it to a production server.
Brian Caffo is a professor in the Department of Biostatistics at Johns Hopkins University. He is known for his work in statistical methodology and applications, particularly in the fields of health and biomedical research. In addition to his academic contributions, Caffo has been involved in teaching and has developed educational resources, including courses in statistical analysis and programming. He is also recognized for his work in the R programming community, contributing to statistical software development and education.
The Tolman–Oppenheimer–Volkoff (TOV) limit is a theoretical maximum mass for a stable, cold neutron star. It arises from the principles of general relativity and describes how the structure of compact stars is affected by gravity and the properties of dense matter. The limit is named after physicists Richard Tolman, J. Robert Oppenheimer, and George Volkoff, who worked on this topic in the 1930s.
"Blanet" does not refer to any widely recognized concept, organization, or term based on my training data up to October 2021. It could be a misspelling, a brand name, a term from a specific niche, or something that has emerged more recently.
Feryal Özel is a renowned astrophysicist known for her work in the fields of astrophysics and planetary science. She has made significant contributions to our understanding of black holes, neutron stars, and the behavior of matter under extreme conditions. Özel has also been involved in the study of gravitational waves and their implications for our understanding of the universe. She is a professor at the University of Arizona and has published numerous research papers, contributing to various scientific discussions and advancements in astronomy.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact