Ciro Santilli invented this term, derived from "hardware in the loop" to refer to simulations in which both the brain and the body and physical world of organism models are modelled.
E.g. just imagine running:
Ciro Santilli invented this term, it refers to mechanisms in which you put an animal in a virtual world that the animal can control, and where you can measure the animal's outputs.
- MouseGoggles www.researchsquare.com/article/rs-3301474/v1 | twitter.com/hongyu_chang/status/1704910865583993236
- Fruit fly setup from Penn State: scitechdaily.com/secrets-of-fly-vision-for-rapid-flight-control-and-staggeringly-fast-reaction-speed/
A Drosophila melanogaster has about 135k neurons, and we only managed to reconstruct its connectome in 2023.
The human brain has 86 billion neurons, about 1 million times more. Therefore, it is obvious that we are very very far away from a full connectome.
Instead however, we could look at larger scales of connectome, and then try from that to extract modules, and then reverse engineer things module by module.
This is likely how we are going to "understand how the human brain works".
Some notable connectomes:
This is the most plausible way of obtaining a full connectome looking from 2020 forward. Then you'd observe the slices with an electron microscope + appropriate Staining. Superintelligence by Nick Bostrom (2014) really opened Ciro Santilli's eyes to this possibility.
Once this is done for a human, it will be one of the greatest milestone of humanities, coparable perhaps to the Human Genome Project. BUt of course, privacy issues are incrediby pressing in this case, even more than in the human genome project, as we would essentially be able to read the brain of the person after their death.
This is also a possible path towards post-mortem brain reading.
This is not a label that Ciro Santilli likes to give lightly. But maybe sometimes, it is inevitable.
Bibliography:
His father fought a lot with the stupid educational system to try and move his son to his full potential and move to more advanced subjects early.
A crime of society to try and prevent it. They actually moved the family from Singapore to Malaysia for a learning opportunity for the son. Amazing.
This is the perfect illustration of one of Ciro Santilli's most important complaints about the 2020 educational system:and why Ciro created OurBigBook.com to try and help fix the issue.
Bibliography:
Ainan Cawley: Child prodigy (2013)
Source. - youtu.be/Ugi74cwPMSg?t=137 finding the right school
This is opposed to messages that may be left by non miners during transactions.
Miner messages are therefore of course much harder to control on established blockchains, as they basically require consensus in a mining pool to set. Most of them are just ads for the mining pool itself.
en.wikipedia.org/wiki/Ruth_Lawrence
When Lawrence was five, her father gave up his job so that he could educate her at home.
www.dailymail.co.uk/femail/article-3713768/Haunting-lesson-today-s-TV-child-geniuses-Ruth-Lawrence-Britain-s-famous-prodigy-tracked-father-drove-heard-troubling-tale.html
he had tried it once before - with an older daughter, Sarah, one of three children he had by a previous marriage.That experiment ended after he separated from Sarah's increasingly concerned mother, Jutta. He soon found a woman more in tune with his radical ideas in his next spouse, Sylvia Greybourne
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.
Figure 4. Visual Studio Code extension tree navigation.
Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact