Narcissism Updated 2025-11-05
Super-resolution microscopy Updated 2025-07-16
Super-resolution means resolution beyond the diffraction limit.
They you can observe fluorophores firing one by one. Their exact position is a bit stochastic and beyond the diffraction limit, but so long as there aren't to many in close proximity, you can wait for it to fire a bunch of times, and the center of the Gaussian is the actual location.
From this we see that super-resolution microscopy is basically a space-time tradeoff: the more time we wait, the better spacial resolution we get. But we can't do it if things are moving too fast in the sample.
Tradeoff with cryoEM: you get to see things moving in live cell. Electron microscopy fully kills cells, so you have no chance of seeing anything that moves ever.
Caveats:
- initial illumination to saturate most fluorophores I think can still kill cells, things get harder the less light you put in. So it's not like you don't kill things at all necessarily, you just get a chance not to
- the presence fluorophore disturbs the system slightly, and is not at the same Exact location of the protein of interest
De novo Updated 2025-07-16
International Organization for Standardization Updated 2025-07-16
Paywall Updated 2025-07-16
Protein folding problem Updated 2025-07-16
Start codon Updated 2025-07-16
Theravada Updated 2025-07-16
Alice&Bob Updated 2025-07-16
About their qubit:
- alice-bob.com/2023/02/15/computing-256-bit-elliptic-curve-logarithm-in-9-hours-with-126133-cat-qubits/ Computing 256-bit elliptic curve logarithm in 9 hours with 126,133 cat qubits (2023). This describes their "cat qubit".
Allan Holdsworth Updated 2025-07-16
Allen Wu Updated 2025-07-16
This situation is the most bizarre thing ever. The dude was fired in 2020, but he refused to be fired, and because he has the company seal, they can't fire him. He is still going to the office as of 2022. It makes one wonder what are the true political causes for this situation. A big warning sign to all companies tring to setup joint ventures in China!
Computer Updated 2025-07-16
The artistic instrument that enables the ultimate art: coding, See also: Section "The art of programming".
Unlike other humans, computers are mindless slaves that do exactly what they are told to, except for occasional cosmic ray bit flips. Until they take over the world that is.
Steve Jobs talking about the Internet (1995)
Source. The web is incredibly exciting, because it is the fulfillment of a lot of our dreams, that the computer would ultimately primarily not be a device for computation, but [sic] metamorphisize into a device for communication.
Secondly it exciting because Microsoft doesn't own it, and therefore there is a tremendous amount of innovation happening.
Computers basically have two applications:Generally, the smaller a computer, the more it gets used for communication rather than computing.
- computation
- communication. Notably, computers through the Internet allow for modes of communication where:
- both people don't have to be on the same phone line at the exact same time, a server can relay your information to other people
- anyone can broadcast information easily and for almost free, again due to servers being so good at handling that
The early computers were large and expensive, and basically only used for computing. E.g. ENIAC was used for calculating ballistic tables.
Communication only came later, and it was not obvious to people at first how incredibly important that role would be.
This is also well illustrated in the documentary Glory of the Geeks. Full interview at: www.youtube.com/watch?v=TRZAJY23xio. It is apparently known as the "Lost Interview" and it was by Cringely himself: www.youtube.com/watch?v=bfgwCFrU7dI for his Triumph of the Nerds documentary.
Computer chess Updated 2025-07-16
Computerphile Updated 2025-07-16
Descriptive statistics Updated 2025-07-16
Symmetric bilinear map Updated 2025-07-16
Subcase of symmetric multilinear map:
The most important example is the dot product, which is also a positive definite symmetric bilinear form.
Computer science Updated 2025-07-16
Unfortunately, all software engineers already know the answer to the useful theorems though (except perhaps notably for cryptography), e.g. all programmers obviously know that iehter P != NP or that this is unprovable or some other "for all practical purposes practice P != NP", even though they don't have proof.
And 99% of their time, software engineers are not dealing with mathematically formulatable problems anyways, which is sad.
The only useful "computer science" subset every programmer ever needs to know is:
- for arrays: dynamic array vs linked list
- for associative array: binary search tree vs hash table. See also Heap vs Binary Search Tree (BST). No need to understand the algorithmic details of the hash function, the NSA has already done that for you.
- don't use Bubble sort for sorting
- you can't parse HTML with regular expressions: stackoverflow.com/questions/1732348/regex-match-open-tags-except-xhtml-self-contained-tags/1732454#1732454 because of formal language theory
Funnily, due to the formalization of mathematics, mathematics can be seen as a branch of computer science, just like computer science can be seen as a branch of Mathematics!
The Busy Beaver Competition: a historical survey by Pascal Michel Updated 2025-07-16
Discretization Updated 2025-07-16
Division algebra Updated 2025-07-16
An algebra over a field where division exists.
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