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The three-nucleotide region of a transfer RNA that recognizes a corresponding codon through base pairing during biological translation.
A peptidyl-tRNA is a transfer RNA carrying the growing peptide chain through a covalent linkage at its acceptor end. During peptide-bond formation, that chain is transferred to the amino acid on another tRNA.
The ribosome then advances the tRNAs and messenger RNA through successive positions. Distinguishing peptidyl-tRNA from an aminoacyl-tRNA makes clear which carrier holds the existing chain and which supplies the next residue.
A transcription factor involved in neural and pluripotent cell states. Coexpression with Brachyury helps identify a neuromesodermal regulatory state but does not alone demonstrate bipotency.
A T-box transcription factor important in posterior and mesodermal development, commonly used with Sox2 to identify neuromesodermal progenitors.
A T-box transcription factor promoting paraxial mesodermal identity in posterior vertebrate development.
A developmental transcription factor; its early ventral expression in Drosophila melanogaster is useful for assaying presumptive mesodermal identity.
A family of developmental transcription factors; early Snail expression helps identify the ventral mesodermal domain of Drosophila melanogaster.
An NF-kappaB-family maternal transcription factor whose ventral nuclear enrichment patterns the early Drosophila melanogaster embryo. Its name does not mean its nuclear activity is highest dorsally.
A transcriptional coactivator regulated by Hippo signalling; its nuclear availability influences TEAD-dependent gene expression.
A family of DNA-binding transcription factors that can cooperate with YAP in lineage-associated gene regulation.
A homeobox transcription factor used as a trophectoderm-associated regulator and marker, with species- and stage-dependent expression.
A pluripotency-associated transcription factor, also called POU5F1. Expression alone does not establish that a cell is functionally pluripotent at every developmental stage.
A pluripotency-associated transcription factor used with other markers to distinguish prospective epiblast from hypoblast.
A GATA-family transcription factor associated with early hypoblast development; its initial coexpression with NANOG can precede lineage resolution.
A Krüppel-like transcription factor associated with the human early pluripotency programme and used in panels of epiblast markers.
Members of related transcription-factor families involved in developmental regulation, including oscillatory feedback during vertebrate somitogenesis.
A developmental transcription factor that supplies temporal regulation of the insect segmentation network, including the transition to single-segment periodicity in Drosophila melanogaster.
A homeobox transcription factor involved in posterior patterning and temporal regulation of insect segmentation.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact