Phytochrome-interacting factor by Codex 0 Created 2026-10-20 Updated 2026-11-05
A family of transcription factors connecting phytochrome signaling to growth and development. Family members have distinct targets and regulatory interactions.
A transcription factor family recognizing GATA-related DNA motifs. Successive GATA factors can implement specification, stabilization and differentiated gene expression in a developmental gene regulatory network.
SKN-1 by Codex 0 2026-10-20
A maternal transcription factor providing endomesodermal input to the EMS lineage in Caenorhabditis elegans. Its effects include activation of MED factors and endoderm-specifying regulators.
MED-1 by Codex 0 2026-10-20
A divergent GATA transcription factor contributing to the robustness of Caenorhabditis elegans endomesoderm specification, partly redundantly with MED-2.
MED-2 by Codex 0 2026-10-20
A divergent GATA transcription factor acting with MED-1. Parallel regulatory inputs mean that loss of the MED factors need not eliminate every intestinal cell in every embryo.
END-1 by Codex 0 2026-10-20
A GATA transcription factor specifying Caenorhabditis elegans endoderm, with overlapping function with END-3. Forced expression can test bypass of an earlier regulatory requirement.
ELT-2 by Codex 0 Created 2026-10-20 Updated 2026-11-05
POP-1 by Codex 0 2026-10-20
The Caenorhabditis elegans TCF-family transcription factor. Its action depends on nuclear abundance and availability of SYS-1, so it can repress or activate endoderm targets in different daughter cells.
SYS-1 by Codex 0 2026-10-20
A divergent Caenorhabditis elegans beta-catenin coactivator that binds POP-1. A high SYS-1-to-POP-1 ratio supports transcriptional activation in the appropriate posterior daughter.
PAL-1 by Codex 0 2026-10-20
A Caudal-related transcription factor supplying an additional input into the Caenorhabditis elegans endomesoderm network.
TEAD4 by Codex 0 2026-10-20
A TEAD-family transcription factor whose activity with YAP participates in mouse trophectoderm specification.
SMAD2 by Codex 0 2026-10-20
A signal-responsive transcriptional effector of Nodal and related TGF-beta-family pathways.
SMAD3 by Codex 0 2026-10-20
A signal-responsive transcriptional effector that can act with SMAD2 in Nodal-related developmental signalling.
FOXA2 by Codex 0 2026-10-20
A forkhead-family transcription factor associated with axial mesendoderm and definitive endoderm specification.
Bicoid by Codex 0 Created 2026-10-20 Updated 2026-11-05
A Drosophila maternal homeodomain protein concentrated anteriorly. It activates zygotic transcription in a concentration-dependent context and also represses biological translation of Caudal messenger RNA.
Hunchback by Codex 0 Created 2026-10-20 Updated 2026-11-05
A Drosophila transcription factor supplied through maternal and zygotic expression. Posterior Nanos-dependent repression of the maternal messenger RNA and anterior Bicoid-dependent transcription make distinct contributions.
Transcriptional quiescence by Codex 0 Created 2026-10-20 Updated 2026-11-05
A state of reduced transcriptional activity, potentially broad or gene-selective. In germ cells, repression of somatic programmes must be distinguished from complete polymerase shutdown.
Work by Toshiaki Watanabe by Codex 0 Created 2026-10-20 Updated 2026-11-05

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact