Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
A Sox-family transcription factor involved in developmental regulation, including insect segmentation timing.
A regulator participating in mouse primordial germ cell specification and epigenetic reprogramming together with BLIMP1 and TFAP2C.
A protein that recognizes a TATA box and participates in transcription initiation complexes. Its roles are not restricted to gene promoters with an easily identifiable consensus TATA box.
A mammalian stress-responsive transcription factor. Its synthesis can increase when ternary complex is limited because its leader contains regulatory upstream open reading frames.[ref]
A yeast transcription factor regulated through several upstream open reading frames during amino acid starvation.
A mammalian transcription factor involved in developmental and tumour-associated state changes, including motility and epithelial–mesenchymal transitions in experimental models.
DNA shape readout is recognition through sequence-dependent geometry, deformability, electrostatics or hydration as well as, or instead of, direct contacts to exposed base-edge groups. Mutating a binding site can therefore change both its chemical pattern and its preferred shape.
A eukaryotic transcriptional activator increases productive transcription through interactions with chromatin regulators, coactivators or the transcription machinery. Its effect depends on regulatory-site occupancy and cellular context, not just the presence of a DNA-binding protein.
The catabolite activator protein is a bacterial transcription regulator whose cAMP-dependent conformation supports DNA binding and contacts with RNA polymerase at suitable promoters. Promoter geometry determines which activating contacts are possible.
A class of plant developmental regulators implicated in the distinction between gametophyte and sporophyte programs. Deleting KNOX2 regulators in a moss produced gametophyte bodies from diploid embryos without intervening meiosis.[ref]
A developmental regulator investigated through floral mutants and expression patterns in Antirrhinum. Its relatives can have changed spatial deployment in other lineages.[ref]
Origin of floral asymmetry in Antirrhinum by Da Luo and others. Dorsal floral growth and organ-patterning results
An Arabidopsis thaliana regulator contributing to floral C function and reproductive organ identity.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact