A plant reproductive-development regulator whose comparative history informs hypotheses about the reorganization of reproductive shoots.

A reproductive regulator related to LEAFY and considered in comparative hypotheses of flower origins. Gene-copy history alone does not determine ancestral organ morphology.

A transcription factor that increases transcription of a target gene. It can act by recruiting or modulating the RNA polymerase machinery and its associated factors.

A T-cell-factor-family regulator in Wnt signalling. Mechanistic claims about specifically named long and short products in an experimental problem require the stated isoform sequences and cellular context.

Hepatocyte nuclear factor 1 beta, a DNA-binding transcriptional regulator. The supplied exam model uses it as an isoform-dependent corepressor; that experimental role should not be generalized to every tissue or target.

RccR is a metabolite-responsive transcriptional regulator of central carbon genes in studied Pseudomonas species. In Pseudomonas aeruginosa, KDPG binding and repression of shunt-associated genes connect carbon state to enzyme expression.

A transcriptional regulator involved in intestinal secretory-lineage specification. Its activity participates in the balance between secretory and absorptive epithelial output.

A transcriptional regulator of antioxidant and detoxification responses. Its protective activity and its effect on relative competitive fitness depend on tissue, activation level and neighbourhood.

A Drosophila counterpart of mammalian NRF2, regulating oxidative-stress-response genes. Its activation can be protective yet also alter neighbour-dependent competitive behaviour.

A LIM-homeodomain transcriptional regulator associated with dorsal limb identity.

A developmental transcriptional regulator whose ventral limb expression helps organize dorsal-ventral signalling boundaries.

A homeodomain transcriptional regulator involved in cardiac specification, progenitor regulation and subsequent heart development. Early and late perturbations can test different functions.

A T-box transcriptional regulator with important roles in heart and limb development.

A family of transcriptional regulators affecting cellular growth and proliferation. Experimental elevation of Drosophila dMyc can drive elimination of lower-expressing neighbours; this is a cell-competition phenotype, not by itself a complete model of cancer.

A transcriptional repression domain used in some dCas9 fusions to recruit repression machinery. Its effect depends on target position and cellular chromatin context.

A family of transcription factors regulating genes involved in cell-cycle progression and DNA replication. RB-associated regulation connects their output to cyclin-dependent-kinase activity.

A transcription factor able to engage certain nucleosomal or otherwise inaccessible DNA contexts and facilitate subsequent regulatory changes. Opening after expression does not alone prove direct pioneer action.

A neurogenic transcription factor whose role in direct neuronal conversion illustrates context-dependent chromatin engagement and hierarchical factor action.^[ref]

A DNA-binding architectural regulator associated with many mammalian chromatin-loop anchors and boundaries. Motif orientation and neighbouring factors affect its architectural roles.

A DNA-binding motif is a recurring DNA sequence pattern recognized preferentially by a DNA-binding protein, particularly a transcription factor. A position weight representation summarizes preferences across sites rather than requiring one invariant word. A high-scoring sequence predicts a candidate site, but chromatin accessibility, protein abundance and cooperative partners affect occupancy in cells. Sequence preference and actual regulatory effect are therefore different claims. ^[ref]