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The branch points are ; infinity has two unbranched meromorphic choices. On the complex plane slit along , normalization at infinity selects a holomorphic square root with boundary values and for . On the exterior real intervals, . A counterclockwise contour integral around the finite branch cut satisfies : the upper lip runs right to left, the lower lip left to right, and the endpoint arcs contribute . The opposite global branch reverses these signs.
H3K27 trimethylation adds three methyl groups to lysine 27 of histone H3, conventionally H3K27me3. It is associated with Polycomb-linked repression of developmental genes in many eukaryotes. Deposition and removal help regulate the persistence of a chromatin state. A broad marked domain describes a molecular state; demonstrating that the mark is required for repression at a particular gene needs a perturbation that separates it from associated factors. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 7, Chromatin Structure and Gene Regulation: Polycomb-associated repression
H3K4 methylation modifies lysine 4 of histone H3 with one, two or three methyl groups. The states have different genomic distributions; trimethylation is often enriched near active transcription start regions. A mark can recruit binding factors or reflect ongoing regulatory activity, so enrichment does not by itself prove that the modification initiated transcription. State, genomic location and experimental perturbation are all needed for a mechanistic claim. [ref]
A plant histone methyltransferase participating in the reinforcing relationship between H3K9 methylation and methylated DNA.
A plant histone methyltransferase participating in the reinforcing relationship between H3K9 methylation and methylated DNA.
A plant histone methyltransferase participating in the reinforcing relationship between H3K9 methylation and methylated DNA.
A chromatin complex that catalyses H3K27 methylation, with locus-specific recruitment and developmental functions.
Its catalytic activity deposits H3K27 methylation, including the trimethylated state associated with many repressed developmental genes. Recruitment and recognition of modified chromatin can stabilize a regulatory state while retaining the possibility of later reversal. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 7, Chromatin Structure and Gene Regulation
Removal of acetyl groups can alter histone interactions and recruitment of chromatin-associated factors. Its association with silencing should be interpreted at the specified loci and developmental stage rather than as a universal consequence of every histone deacetylation event. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 4–7, chromatin, replication and gene regulation
The slope of against in a Hill equation description. A value above one supports positive cooperative binding under the model's assumptions. It does not by itself count occupied sites or identify a molecular mechanism.
A Hill activation function is an increasing saturating input function for phenomenological regulation of gene expression. For positive , its value is one-half at . The Hill coefficient controls steepness; it need not equal a literal molecular binding-site count.
The positive concentration giving half of the maximal response in a Hill equation. This effective threshold need not equal an individual binding site's microscopic dissociation constant.
In the multiplicative set of Hilbert numbers, a squarefree Hilbert number is one divisible by no square of a Hilbert number . This is weaker than being a squarefree integer: is a squarefree Hilbert number because its square divisor has outside the Hilbert numbers.
The spore type developing into a male gametophyte. Its production is distinct from the later production of sperm.
A megaspore is the spore type that develops into a female gametophyte in a heterosporous life cycle. It is distinct from an ovum: the megaspore begins a developmental generation, whereas an ovum is a gamete that fuses during fertilization.
The corresponding male-producing spore is a microspore. Following both spore types helps connect heterospory to the strongly reduced gametophytes of seed plants.
Extension of a repressive chromatin domain beyond its initial nucleation site. Reader–writer positive feedback can propagate local marks, while histone turnover, opposing activities and chromatin boundaries constrain the domain.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





