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Colony-stimulating factor 1, a signal promoting survival and cell differentiation within monocyte/macrophage lineages and participating in some tumour–macrophage interactions.
Vascular endothelial growth factor, a family of signals that regulate vascular development and function, including angiogenic responses in tumours.
A signalling cascade connecting RAS-family switches and downstream kinases to regulatory outputs including proliferation and cell differentiation.
A cytokine influencing T-cell growth and function, including use in some adoptive-cell-therapy regimens.
Secreted IL-2 acts through a receptor system whose abundance and composition affect responsiveness. It can support expansion and survival of activated lymphocytes while also contributing to immune regulation, so its effect depends on the responding biological population. [ref]
Immunobiology: The Immune System in Health and Disease, 5th edition by Charles A. Janeway, Jr. and others. Chapter 8, T Cell-Mediated Immunity: activation and growth factors
Cellular responses to interferon gamma, including context-dependent effects on proliferation and antigen presentation. Loss of responsiveness can contribute to immune-therapy escape.
mechanotransduction converts mechanical input into altered molecular activity or cellular behavior. A causal test separates applied mechanics from accompanying chemical changes and identifies a force-sensitive step.
hippo signaling regulates growth-related transcriptional outputs, including the activity and localization of YAP and TAZ. Mechanical inputs can intersect with this network through context-dependent routes.
Signalling by bone morphogenetic proteins, with context-dependent effects on specification, growth and spatial organization. A developmental patterning function is distinct from a generic effect on cell differentiation.
Regulation of cellular activity through oxidation-reduction-sensitive processes. A stress-response reporter measures a downstream response and need not directly report the concentration of a particular oxidant.
Signalling that connects receptor-associated Janus kinases to STAT transcriptional regulators. In epithelial mosaics, ligand production and response can influence growth of both affected and neighbouring biological populations.
Regulation involving production, accumulation and detection of extracellular signals. Signal concentration depends on transport and environment as well as biological population density.
Regulation by changes in free intracellular calcium ion concentration. Calcium signatures are interpreted through calcium-binding sensors and downstream targets; calcium concentration is not itself the final response.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact