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A variational approximation restricting a many-electron wavefunction to one Slater determinant. Minimizing its energy gives self-consistent one-electron equations with Coulomb and exchange operators. It includes exchange from antisymmetry but omits correlation beyond the determinant.
An iterative orbital calculation in which the effective one-electron operator depends on the density built from its own occupied orbitals. Self-consistency is a stationarity condition, not a guarantee that the solution is the lowest-energy one.
A variational expansion over Slater determinants or spin-adapted configuration functions in a fixed orbital basis. Truncating the configurations restricts the correlation described.
A framework describing electronic ground-state properties using the electron density. Practical approximations require an exchange-correlation functional; this does not mean that explicit electrons have been replaced by a classical atom-only force field.
A sulfotransferase whose ventrally restricted expression in ovarian follicle cells helps orient extracellular activation of the embryonic dorsal-ventral patterning system in Drosophila melanogaster.
A sequence of regulated protein-cleavage events in which activation of one component permits activation of another. Spatial restriction can turn widely supplied precursors into a local signal.
A ligand whose proteolytically activated form stimulates the Toll receptor in Drosophila melanogaster.
Proteolytic processing makes the receptor-active ligand available at the appropriate place and time. This separates production of a precursor from creation of an active extracellular signal, allowing localization of a developmental response. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 21, Early Animal Development: dorsal-ventral patterning
An inhibitory protein that restrains Dorsal protein nuclear activity in Drosophila melanogaster; regulated removal of that inhibition is part of embryonic ventral patterning.
An organising protein for Drosophila melanogaster germ plasm; ectopic local expression can redirect germ-cell formation in a permissive cellular context.
A germ-plasm component in Drosophila melanogaster that participates in organising germline-associated molecular assemblies.
A developmental translational regulator important in germ-cell development and, in some contexts, posterior body patterning.
Its interactions with RNA-binding partners can repress biological translation or promote removal of selected messages. This permits different protein output from cells that inherited similar RNA supplies, connecting post-transcriptional regulation to embryonic patterning. [ref]
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos by Robin P. Wharton and Gary Struhl. 1991, translational control through RNA regulatory elements
The small polar granule component protein that represses productive transcription in early fly pole cells by interfering with P-TEFb recruitment.
Positive transcription elongation factor b, a kinase complex promoting productive RNA polymerase II elongation, including phosphorylation of the polymerase C-terminal domain.
A maternally supplied protein segregating to germline blastomeres in Caenorhabditis elegans, where it suppresses inappropriate somatic transcription.
A precursor of a digestive enzyme. Portions of an ancestral trypsinogen gene contributed to the origin of an Antarctic fish antifreeze glycoprotein; this does not mean that the new product retained the original digestive function.
A protein-protein interaction is an association between proteins through physical contact. Copurification or proximity labeling can suggest an association without establishing that the measured pair contacts directly.
An affinity tag is an engineered sequence or chemical attachment used to capture a protein selectively. Tag placement and abundance need validation because the tag can alter protein folding, subcellular localization or partner binding.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact