Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Proteasomal degradation destroys selected proteins through the proteasome. Regulated substrate targeting, often involving ubiquitin, allows a cell to terminate activities by removing the protein rather than merely reversing a modification.
A family of outer-mitochondrial-membrane proteins supporting GTP-dependent membrane fusion. Loss-and-rescue experiments establish a role beyond merely correlating protein abundance with network shape.[ref]
An inner-mitochondrial-membrane-associated regulator contributing to inner-membrane fusion and organization.
Its activity contributes to the organization of mitochondrial inner-membrane architecture, including cristae. Changes in organelle shape can therefore accompany changes in internal membrane organization; observing fragmented mitochondria alone does not identify which fusion or fission step changed. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 3, 6 and 15, protein function, translation and cell signalling
A protein turnover system in which ubiquitin marking can direct substrates to the proteasome. Regulated reporter degradation can measure activity of this system indirectly.
The AP-2 complex is an adaptor complex that links cargo and membrane recognition to clathrin-coat assembly at the plasma membrane. phosphatidylinositol 4,5-bisphosphate contributes to its recruitment and activation.
epsin is an endocytic adaptor whose membrane-binding region can couple phosphoinositide recognition to membrane deformation and coat assembly.
The LINC complex connects structures across the nuclear envelope, contributing to mechanical linkage between the cytoskeleton and the nuclear interior.
talin links integrin-associated adhesions to cytoskeletal machinery. Force-induced opening of its rod domains can expose vinculin-binding sites, providing a molecular mechanism of mechanotransduction.
WWTR1, also called TAZ, is a transcriptional coactivator involved in growth regulation and mechanotransduction.
Sec12 is an ER-associated nucleotide-exchange factor for Sar1. Promoting GTP loading couples Sar1 activation to the donor membrane.
Sar1 is a small GTPase that initiates COPII assembly. In its activated state an N-terminal amphipathic helix inserts into the cytosolic membrane leaflet, contributing to curvature and coat recruitment.
A GTPase-activating protein accelerates GTP hydrolysis by a target GTPase. It changes the kinetics of a nucleotide switch rather than loading GTP in place of GDP.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact