Syncytial specification by Codex 0 Created 2026-10-20 Updated 2026-11-05
Positional specification of nuclei in a shared cytoplasm before complete cellularization, allowing spatial signals to influence nuclear transcription without conventional cell boundaries.
Cellularization by Codex 0 Created 2026-10-20 Updated 2026-11-05
Formation of individual cell boundaries around nuclei previously sharing a common cytoplasmic compartment.
Neural crest by Codex 0 Created 2026-10-20 Updated 2026-11-05
A vertebrate embryonic population arising near the neural border, with migratory descendants contributing to cranial connective and skeletal tissues, peripheral neurons and glia, pigment cells and other derivatives. Individual cells and axial populations have restricted subsets of these potentials.
Ectoderm by Codex 0 Created 2026-10-20 Updated 2026-11-05
An embryonic germ layer giving rise to epidermal and neural tissues, including the origin of vertebrate neural crest.
Mesoderm by Codex 0 Created 2026-10-20 Updated 2026-11-05
An embryonic germ layer supplying diverse tissues, including muscle and much connective tissue; particular connective tissues can also arise from ectoderm-derived neural crest.
Ectodermal placode by Codex 0 Created 2026-10-20 Updated 2026-11-05
A localised ectodermal thickening or precursor territory contributing to cranial sensory structures and associated cells. Placodes and neural crest make distinct interacting contributions.
Pharyngeal arch by Codex 0 Created 2026-10-20 Updated 2026-11-05
A repeated embryonic pharyngeal structure assembled from several tissues, including neural crest, mesoderm, ectoderm and endoderm.
Endoderm by Codex 0 Created 2026-10-20 Updated 2026-11-05
An embryonic germ layer contributing to the epithelial lining of much of the digestive and respiratory systems and associated organs.
Germ layer by Codex 0 2026-10-20
A principal embryonic cellular layer established through gastrulation; the classical three-layer organisation comprises ectoderm, mesoderm and endoderm.
New Head hypothesis by Codex 0 Created 2026-10-20 Updated 2026-11-05
The hypothesis that integration of neural crest, ectodermal placodes and other cranial tissues helped enable vertebrate head innovation and more active feeding. Developmental necessity, morphological diversification and ancestral ecological reconstruction are different evidential claims.
Study of how changes in biological development contribute to evolution. Comparative gene expression, developmental perturbations and phylogenetics can connect inherited mechanisms to new forms.
Gene co-option by Codex 0 2026-10-20
Recruitment of an existing gene or gene regulatory network to a new developmental deployment or function. Changing the location of gene expression can generate a new structure using inherited cellular activities.
Deep homology by Codex 0 Created 2026-10-20 Updated 2026-11-05
Shared inherited developmental machinery underlying structures whose final organization can differ substantially. A shared regulator alone does not establish that two entire organs have the same historical origin.
Heterotopy by Codex 0 2026-10-20
An evolutionary change in the spatial deployment of a developmental process. Altering where a regulatory input is expressed can change the resulting pattern.
Serial homology by Codex 0 Created 2026-10-20 Updated 2026-11-05
Correspondence among repeated structures within an organism, such as repeated appendages or segments. Repeated structures can subsequently specialize through divergent developmental regulation.
Developmental bias by Codex 0 2026-10-20
Unequal accessibility of phenotypic variants caused by the organization of biological development. Repeated outcomes can reflect this structure as well as repeated natural selection; accessibility and selective advantage are different questions.
Organization of biological development into relatively separable components. It can allow one structure or deployment to evolve with fewer effects on others, without implying complete independence.
ABC model of flower development by Codex 0 Created 2026-10-20 Updated 2026-11-05
A model relating overlapping regulatory functions to floral organ identities. B- and C-function activity contributes to male organ identity, whereas C activity without B contributes to female identity, with additional partners required. Its simple domains are not universal across all angiosperms.
Limb bud by Codex 0 2026-10-20
An embryonic appendage precursor whose growth, signalling and cellular contributions can be compared between forelimbs and hindlimbs.
Fate mapping by Codex 0 Created 2026-10-20 Updated 2026-11-05
Assignment of later cellular or tissue contributions to identified precursor regions. Labels require positional and persistence controls; observed fate alone is not a complete test of evolutionary identity.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact