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A developmental biologist studies the processes that form and organize living bodies. Experiments on cell fate, signaling and morphogenesis connect changes in genes or environment to specific developmental outcomes. Comparing different organisms also reveals how developmental processes change through evolution.
A tissue organization with cells dispersed through extracellular matrix, rather than arranged as a continuous polarized epithelium. Mesenchymal populations differ in origin and developmental potential.
Formation, regionalization and maturation of the intestine, including its epithelial surface, supporting tissues and renewing cell populations.
Replacement of lost biological structures through organized growth and differentiation. Recovery of mass alone need not demonstrate restoration of the original pattern or function.
A population of cardiac progenitors that contributes cells to the developing heart after initial heart-tube formation. Retaining a proliferative reservoir allows progressive addition of differentiated myocardium.
The inner endothelial lining of the heart, which also provides developmental signals to neighbouring myocardium.
Neural development forms and organizes neurons, supporting cells and their connections. It includes precursor production, specification of cell types, migration, axon guidance and later changes in synaptic connectivity. Making the right number of cells and connecting them appropriately are distinct developmental requirements.
Skin development forms the epidermis, underlying supporting tissues and appendages such as hair follicles or feathers, depending on the lineage. Interactions between an epithelium and underlying mesenchyme help specify where appendages arise and how they grow.
Lung development builds the conducting airways and the thin exchange surface needed for breathing after birth. Growth and branching must be coordinated with cell differentiation, blood vessel development and preparation for air-filled function.
Mechanical conditions are part of the developmental signal. Live imaging and force perturbations linked fetal breathing movements and fluid loading to differentiation of type I alveolar cells, while local growth-factor responses helped other progenitors retain type II alveolar cell identity. This connects cell shape and tissue forces to acquisition of gas-exchange function.[ref]
The timing and ordering of specification, differentiation, tissue movement and maturation. Equal chronological age need not imply equal developmental stage after perturbation.
Heart development produces the pumping organ, its chambers, lining and supporting structures through coordinated differentiation and morphogenesis. The early heart tube changes shape through cardiac looping and receives further cellular contributions; changes in shape, cell number and cell identity are separable processes.
In zebrafish, fluorescent developmental-timing assays and a photoconvertible fluorescent protein distinguished early differentiation from later addition at the arterial pole of the heart. These experiments showed why growth of the heart cannot be explained solely by division of already differentiated cardiac cells.[ref]
Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart by Emma de Pater and others. Summary; transgenic timing and photoconversion assays
Formation and differentiation of plant tissues and organs, continuously influenced by internal state and the environment.
Attachment and embedding of a mammalian conceptus in maternal tissue. Embryonic and extraembryonic tissues undergo coordinated morphogenesis during this transition.
The transition from predominant reliance on maternally supplied products to zygotic gene expression, accompanied by regulated turnover or redeployment of maternal molecules.
A representation of a finite set of bounded nonnegative integers by a binary word: bit is 1 exactly when belongs to the set. Bitwise AND, OR, and XOR implement intersection, union, and symmetric difference. A large integer can store the whole word when the programming language provides arbitrary-precision integers.
A binary tree organizing a fixed sequence into recursively subdivided contiguous intervals. Each node stores an aggregate for its interval. Range queries and point updates visit logarithmically many nodes; range-update variants store additional information such as a coverage count to maintain the length of a union of active intervals.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





