The first found and most important known epigenetic marker.

Happens only on adenine and cytosine. Adenine methylation is much less common in mammal than cytosine methylation, when people say "methylation" they often mean just cytosine methylation.

It often happens on promoters, where it inhibits transcription.

2021-01-28: used this show for the first time after wearing dhb Dorica MTB Shoe (2020-12) exclusively for a while. It felt much much more comfortable, the Dorica is too narrow. Also this one is much more recessed, and walking with it is much easier. Also, I notice that the intentional asymmetry I had put on cleats is not necessary anymore now that my saddle height is not way too high

At 5C feet are too cold. Compatible overshoes are basically impossible to find: bicycles.stackexchange.com/questions/73589/what-kind-of-overshoes-can-i-use-with-a-large-touring-spd-cycling-shoe-such-as-t

It is not possible to do long walks with this, unlike some websites suggests, especially on hard surfaces like rock, that would be very dangerous because the cleat area will slip. But it is good for shorter walks on grass/mud, and that does open up some good short walk exploration possibilities compared to a road shoe.

Color "Black/Red 20" (but it's actually orange), size 46 www.wiggle.co.uk/giro-rumble-vr-off-road-shoe (archive). Manual says to use Loctite 243 medium strength, first 2.4 Nm bolt torque to test it out and find good position, and then final bolt torque 5-6 Nm unless cleat says less. Starting with Shimano SM-SH56 cleats (archive), which also says provisional torque 2.5 Nm, tightening torque 5-6 Nm.

Google has put considerable effort into custom hardware to greatly optimize its stack, in a way that is quite notable compared to other tech companies.

E.g. about.google/ in 2022.

3D area.