Ion channel toxins are specialized proteins or small molecules that disrupt the normal functioning of ion channels in cell membranes. Ion channels are integral membrane proteins that allow the selective passage of ions (such as sodium, potassium, calcium, and chloride) across cell membranes, playing critical roles in various physiological processes, including nerve impulse transmission, muscle contraction, and hormone secretion.
The Exponential distribution is a continuous probability distribution often used to model the time between events in a Poisson process. This distribution is characterized by its memoryless property, which implies that the probability of an event occurring in the next instant is independent of how much time has already elapsed.
Henry E. Brady is a notable figure in the field of political science and public policy. He is known for his work in policy analysis, research methodology, and survey research. Brady has been associated with various academic institutions, primarily the University of California, Berkeley, where he has contributed to the fields of political science and public policy through teaching, research, and publications. His research often focuses on topics such as political behavior, public opinion, and the intersections of politics and social science.
Statistical reliability refers to the consistency and dependability of a measurement or assessment tool in producing stable and consistent results over time. In other words, it assesses the degree to which an instrument yields the same results under the same conditions, thus indicating its stability and accuracy. ### Key Concepts Related to Statistical Reliability: 1. **Types of Reliability**: - **Test-Retest Reliability**: Measures consistency over time. The same test is administered to the same group at different times.
A plane table is a surveying instrument used for mapping and land surveying. It consists of a horizontal flat surface (the table) mounted on a leveling device, such as a tripod. The primary components of a plane table setup include: 1. **Table**: A flat board or surface where the surveying is done. The surface typically has a grid or layout for plotting points. 2. **Tripod**: A three-legged support that holds the table in a stable and level position.
A ranging rod is a surveying tool used in various fields, such as construction and land surveying, to establish straight lines or points over a distance. It is typically a long, slender pole, often made of wood or fiberglass, and marked with measurements or graduations. Ranging rods are used in conjunction with other surveying equipment, such as levels and theodolites, to ensure accurate alignment and measurements.
There are several alternatives to car use that can help reduce traffic congestion, lower emissions, and promote a healthier lifestyle. Here are some common options: 1. **Public Transportation**: Buses, trains, subways, and trams offer convenient ways to travel without a car. They are often more economical and can reduce the number of vehicles on the road. 2. **Bicycling**: Riding a bicycle is a great way to get around, especially for shorter distances.
The Discrete Weibull distribution is a probability distribution that is used to model data that can be represented in discrete form, particularly where the data exhibit characteristics similar to those described by the continuous Weibull distribution. While the Weibull distribution is commonly used for modeling life data, reliability, and failure times, the discrete version applies to situations where events occur at discrete points in time or with discrete observations.
The Nelson–Aalen estimator is a non-parametric estimator used in survival analysis to estimate the cumulative hazard function based on censored survival data. It is especially useful when dealing with time-to-event data where some observations may be censored, meaning that for some subjects, we only know that the event has not occurred by the end of the study or observation period.
The Weibull distribution is a continuous probability distribution named after Wallodi Weibull, who described the distribution in 1951. It is widely used in reliability engineering, life data analysis, and survival studies, among other fields, to model the time until an event occurs, such as failure or death.
Carsharing is a transportation service that allows multiple users to rent vehicles for short periods of time, typically by the hour or day, rather than owning a car. This service is designed to provide the convenience of vehicle access without the costs and responsibilities associated with car ownership, such as maintenance, insurance, and parking. Key features of carsharing include: 1. **Accessibility**: Users can easily reserve a vehicle through mobile apps or websites.
The Bedford Green Wheel is a cycle route and walking path network located in and around the town of Bedford, England. It is designed to promote cycling and walking as sustainable forms of transport while enhancing the access to the surrounding natural environments and green spaces. The initiative aims to encourage outdoor activities, improve public health, and support local biodiversity.
Bicing is a public bicycle-sharing service in Barcelona, Spain. Launched in 2007, it is designed to promote sustainable transport and reduce traffic congestion in the city. Users can rent bicycles from designated stations located throughout Barcelona for short periods, typically up to 30 minutes per trip without additional charges. To use Bicing, individuals typically need to register online and can pay for a subscription, either for a single year or a shorter duration.
The California Air Resources Board (CARB) is the state agency responsible for regulating air quality in California. It was established in 1967 and operates under the California Environmental Protection Agency (CalEPA). CARB's primary mission is to achieve and maintain healthy air quality for all Californians, which includes reducing air pollution and greenhouse gas emissions.
A Certificate of Entitlement (COE) is a key component of the vehicle registration system in Singapore. It is essentially a license that allows an individual to own and use a vehicle in Singapore for a specified period, typically ten years. The COE system was introduced to regulate the number of vehicles on the road and manage congestion.
"Complete Streets" is a transportation policy and design approach aimed at creating roadways that prioritize all users, including pedestrians, cyclists, motorists, and public transportation riders. The goal is to provide safe and accessible transportation options for everyone, regardless of age or ability. Key features of Complete Streets include: 1. **Multimodal Infrastructure:** Development of infrastructure that accommodates various forms of transportation, such as bike lanes, sidewalks, crosswalks, public transit facilities, and roadways for vehicles.
Induced demand refers to the phenomenon whereby an increase in the supply of a good or service leads to an increase in its consumption. This concept is often discussed in the context of transportation and urban planning, particularly concerning roadways and infrastructure. In simpler terms, when new roads are built or existing roads are expanded, the immediate expectation might be that traffic congestion will decrease and travel times will improve. However, the new or expanded roadways can lead to an increase in the number of vehicles on the road.
Park and ride is a transportation concept designed to encourage people to use public transit while alleviating congestion in urban areas. It typically involves designated parking lots or facilities located at strategic points outside a city center or high-traffic area. Here’s how it generally works: 1. **Parking Facilities**: Commuters can park their vehicles in these designated lots, which are usually equipped with sufficient spaces and amenities for users.
NEC Green Wheels is an initiative by NEC Corporation focused on promoting sustainable and environmentally friendly transportation solutions. It aims to address challenges related to traffic congestion, carbon emissions, and the need for efficient mobility in urban areas. The initiative often involves the development and implementation of electric vehicles (EVs), smart transportation systems, and related technologies that enhance sustainability in urban mobility.
Smart growth is an urban planning and development approach that aims to create sustainable, livable communities by encouraging efficient land use, transportation options, and environmental stewardship. The key principles of smart growth include: 1. **Compact Development**: Promoting higher density development and mixed-use zoning to reduce the need for extensive infrastructure and urban sprawl. 2. **Walkability**: Designing neighborhoods that encourage walking and biking, making it easier for residents to access shops, services, and public transportation.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.Figure 4. Visual Studio Code extension tree navigation.Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





