100 Greatest Discoveries by the Discovery Channel (2004-2005) by 
Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli 40 Updated 2025-07-16Hosted by Bill Nye.
Physics topics:
- Galileo: objects of different masses fall at the same speed, hammer and feather experiment
- Newton: gravity, linking locally observed falls and the movement of celestial bodies
- TODO a few more
- superconductivity, talk only at Fermilab accelerator, no re-enactment even...
- quark, interview with Murray Gell-Mann, mentions it was "an off-beat field, one wasn't encouraged to work on that". High level blablabla obviously.
- fundamental interactions, notably weak interaction and strong interaction, interview with Michio Kaku. When asked "How do we know that the weak force is there?" the answer is: "We observe radioactive decay with a Geiger counter". Oh, come on!
biology topics:
- Leeuwenhoek microscope and the discovery of microorganisms, and how pond water is not dead, but teeming with life. No sample of course.
- 1831 Robert Brown cell nucleus in plants, and later Theodor Schwann in tadpoles. This prepared the path for the idea that "all cells come from other cells", and the there seemed to be an unifying theme to all life: the precursor to DNA discoveries. Re-enactment, yay.
- 1971 Carl Woese and the discovery of archaea
Genetics:
- Mendel. Reenactment.
- 1909 Thomas Hunt Morgan with Drosophila melanogaster. Reenactment. Genes are in Chromosomes. He observed that a trait was linked to sex, and it was already known that sex was related to chromosomes.
- 1935 George Beadle and the one gene one enzyme hypothesis by shooting X-rays at bread mold
- 1942 Barbara McClintock, at Cold Spring Harbor Laboratory
- 1952 Hershey–Chase experiment. Determined that DNA is what transmits genetic information, not protein, by radioactive labelling both protein and DNA in two sets of bacteriophages. They observed that only the DNA radioactive material was passed forward.
- Crick Watson
- messenger RNA, no specific scientist, too many people worked on it, done partially with bacteriophage experiments
- 1968 Nirenberg genetic code
- 1972 Hamilton O. Smith and the discovery of restriction enzymes by observing that they were part of anti bacteriophage immune-system present in bacteria
- alternative splicing
- RNA interference
- Human Genome Project, interview with Craig Venter.
Medicine:
- blood circulation
- anesthesia
- X-ray
- germ theory of disease, with examples from Ignaz Semmelweis and Pasteur
- 1796 Edward Jenner discovery of vaccination by noticing that cowpox cowpox infected subjects were immune
- vitamin by observing scurvy and beriberi in sailors, confirmed by Frederick Gowland Hopkins on mice experiments
- Fleming, Florey and Chain and the discovery of penicillin
- Prontosil
- diabetes and insulin
If there is one thing that makes Ciro Santilli learn German, this is it (the Romance language are all the same, so reading them is basically covered for Ciro already).
1-2 to hour long interviews, the number of Nobel Prize winners is off-the-charts. The videos have transcripts on the description!
The proper precise definition of mathematics can be found at: Section "Formalization of mathematics".
The most beautiful things in mathematics are described at: Section "The beauty of mathematics".
Study Hilbert spaces desert dilemma meme
. Source. Applies to almost all of mathematics of course. But we don't care, do we!One of the most beautiful things in mathematics are theorems of conjectures that are very simple to state and understand (e.g. for K-12, lower undergrad levels), but extremely hard to prove.
This is in contrast to conjectures in certain areas where you'd have to study for a few months just to precisely understand all the definitions and the interest of the problem statement.
Bibliography:
- mathoverflow.net/questions/75698/examples-of-seemingly-elementary-problems-that-are-hard-to-solve
- www.reddit.com/r/mathematics/comments/klev7b/whats_your_favorite_easy_to_state_and_understand/
- mathoverflow.net/questions/42512/awfully-sophisticated-proof-for-simple-facts this one is for proofs for which simpler proofs exist
- math.stackexchange.com/questions/415365/it-looks-straightforward-but-actually-it-isnt this one is for "there is some reason it looks easy", whatever that means
Examples:
- classification of finite simple groups
- classification of regular polytopes
- classification of closed surfaces, and more generalized generalized Poincaré conjectures
- classification of associative real division algebras
- classification of finite fields
- classification of simple Lie groups
- classification of the wallpaper groups and the space groups
Oh, and the dude who created the en.wikipedia.org/wiki/Exceptional_object Wikipedia page won an Oscar: www.youtube.com/watch?v=oF_FLN-TmCY, Dan Piponi, aka
@sigfpe. Cool dude.Cool examples:
Ciro Santilli would like to fully understand the statements and motivations of each the problems!
Easy to understand the motivation:
- Navier-Stokes existence and smoothness is basically the only problem that is really easy to understand the statement and motivation :-)
- p versus NP problem
Hard to understand the motivation!
- Riemann hypothesis: a bunch of results on prime numbers, and therefore possible applications to cryptographyOf course, everything of interest has already been proved conditionally on it, and the likely "true" result will in itself not have any immediate applications.As is often the case, the only usefulness would be possible new ideas from the proof technique, and people being more willing to prove stuff based on it without the risk of the hypothesis being false.
- Yang-Mills existence and mass gap: this one has to do with finding/proving the existence of a more decent formalization of quantum field theory that does not resort to tricks like perturbation theory and effective field theory with a random cutoff valueThis is important because the best theory of light and electrons (and therefore chemistry and material science) that we have today, quantum electrodynamics, is a quantum field theory.
Nice result on Lebesgue measurable required for uniqueness.
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