Ciro Santilli @cirosantilli  40

The by far dominating DNA sequencing company of the late 2000's and 2010's due to having the smallest cost per base pair.

Illumina actually bought their 2010's dominating technology from a Cambridge company called Solexa.

To understand how Illumina's technology works basically, watch this video: Video 1. "Illumina Sequencing by Synthesis by Illumina (2016)".

The key innovation of this method is the Bridge amplification step, which produces a large amount of identical DNA strands.

They put a lot of emphasis into base calling. E.g.:

Incredible that there hasn't been a Nobel Prize for it as of 2022, e.g. as mentioned at: theconversation.com/no-nobel-but-epigenetics-finally-gets-the-recognition-it-deserves-18970

Some old dudes getting another prize in 2016: www.cuimc.columbia.edu/news/pioneers-epigenetics-awarded-horwitz-prize

The main way to sequence DNA methylation. Converts methylated cytosine to uracil, and then we can sequence those.

There are 3: real numbers, complex numbers and quaternions.

Notably, the octonions are not associative.

Ciro Santilli has a hard time understanding why this is possible, e.g. many people use short 4 digit pins, or a short swipe pattern. Why can't this be cracked easily offline?

Can we do better than "wrong password implies random bytes"?

Can the last disk access times be checked via forensic methods?

Users:

This is hot shit, a possible worst case but sure to get there scenario to understand the brain!