Genomics Updated 2025-07-16
Study of the genome, one of the omics.
Gilberto Gil Updated 2025-07-16
Gilberto is definitely the most psychedelic/tribal one of the The Holy Trinity of popular Brazilian music, though he also has a boyish quality to his soul.
He is also perhaps the one that impresses Ciro Santilli the most, at times he can't help but feel:
OMG how the hell did he come up with that?!
Figure 2.
Gilberto Gil in the cover of his 1977 album Refavela
. Source.
OurBigBook.com / Manifesto Updated 2025-07-16
Education has become an expensive bureaucratic exercise, completely dissociated from reality and usefulness.
It completely rejects what the individual wants to achieve, and instead attempts to mass homogenize and test people through endless hours of boredom.
And the only goals it achieves are testing student's resilience to stress, and facilitating the finding of sexual partners. True learning is completely absent.
Teachers only teach because they have to do it to get paid, not for passion. Their only true incentive is co-authoring papers.
We reject this bullshit.
Education is meant to help us, the students, achieve our goals through passionate learning.
And, we, the students, are individuals, with different goals and capabilities.
The way we protest is to publish the knowledge from University for free, on the Internet, so that anyone can access it.
And we do this is a law-abiding way, without copyright infringement, so that no one can legally take it down.
We come to our courses just for the useless roll calls. But we already know all the subject better than the "teacher" on the very first day.
And we are already more famous than the "teacher" online, and through the Internet have already taught more way way more people than they ever will.
The effect of this is to demoralize the entire school system at all levels, until only one conclusion is possible: implosion.
And from the ashes of the old system, we will build a new one, which does only what matters with absolute efficiency: help the individual students achieve their goals.
A system in which the only reason why university exist will be to allow the most knowledgeable students to access million dollar laboratory equipment, and to pay the most prolific content creators so they can continue content creating.
No more useless courses. No more useless tests. Only passion, usefulness and focus.
It would be really cool to have a PageRank-link algorithm that answers the key questions:
However, Ciro has decided to leave this for phase two action plan, because it is impossible to tune such an algorithm if you have no users or test data.
Perhaps it is also worth looking into ExpertRank, they appear to do some kind of "expert in this area", but with clustering (unlike us, where the clustering would be more explicit).
Other dump of things worth looking into:
GHDL Updated 2025-07-16
Examples under vhdl.
First install GHDL. On Ubuntu:
sudo apt install verilator
Tested on Verilator 1.0.0, Ubuntu 22.04.
Run all examples, which have assertions in them:
cd vhdl
./run
OurBigBook.com / Stack Exchange Updated 2025-07-16
Stack Exchange solves to a good extent the use cases:
points of view. It is a big open question if we can actually substantially improve it.
Major shortcoming are mentioned at idiotic Stack Overflow policies:
Because Ciro's a software engineer, and he's done enough staring in computers for a lifetime already, and he believes in the power of Git, he didn't pay much attention to this part ;-)
According to the eLife paper, the code appears to have been uploaded to: github.com/d-j-k/puntseq. TODO at least mention the key algorithms used more precisely.
Ciro can however see that it does present interesting problems!
Because it was necessary to wait for 2 days to get our data, the workshop first reused sample data from previous collections done earlier in the year to illustrate the software.
First there is some signal processing/machine learning required to do the base calling, which is not trivial in the Oxford Nanopore, since neighbouring bases can affect the signal of each other. This is mostly handled by Oxford Nanopore itself, or by hardcore programmers in the field however.
After the base calling was done, the data was analyzed using computer programs that match the sequenced 16S sequences to a database of known sequenced species.
This is of course not just a simple direct string matching problem, since like any in experiment, the DNA reads have some errors, so the program has to find the best match even though it is not exact.
The PuntSeq team would later upload the data to well known open databases so that it will be preserved forever! When ready, a link to the data would be uploaded to: www.puntseq.co.uk/data
gitk Updated 2025-07-16
Figure 1.
gitk 2.34.1 running on Ubuntu 22.04 with a simple repository.
git rebase does not tell you that, and that sucks.
We only know which commit from the feature branch caused the problem.
Generally we can guess or it is not needed, but imerge does look promising: stackoverflow.com/questions/18162930/how-can-i-find-out-which-git-commits-cause-conflicts
Git tips / git log --graph Updated 2025-07-16
For the strong.
git log --abbrev-commit --decorate --graph --pretty=oneline master HEAD
Output:
* b4ec057 (master) 5
* 0b37c1b 4
| * fbfbfe8 (HEAD -> my-feature) 7
| * 7b0f59d 6
|/
* 661cfab 3
* 6d748a9 2
* c5f8a2c 1
If we also add the --simplify-by-decoration, which you very often want want on a real repository with many commits:
* b4ec057 (master) 5
| * fbfbfe8 (HEAD -> my-feature) 7
|/
* c5f8a2c 1
As we can see, this removes any commit that is neither:
  • under a branch or tag
  • at the intersection of too branches or tags
In order to solve conflicts, you just have to understand what commit you are trying to move where.
E.g. if from:
5 master
|
4 7 my-feature HEAD
| |
3 6
|/
2
|
1
we do:
git rebase master
what happens step by step is first 6 is moved on top of 5:
6on5 HEAD
|
5 master
|
4                 7 my-feature
|                 |
3                 6
|                 |
2-----------------+
|
1
and then 7 is moved on top of the new 6:
7on5 HEAD
|
6on5
|
5 master
|
4                 7 my-feature
|                 |
3                 6
|                 |
2-----------------+
|
1
All good? so OK, let's move the my-feature to the new 7:
7on5 my-feature HEAD
|
6on5
|
5 master
|
4
|
3
|
2
|
1
Generate a minimal test repo. You should get in the habit of doing this to test stuff out.
#!/usr/bin/env bash

mkdir git-tips
cd git-tips
git init

for i in 1 2 3 4 5; do
  echo $i > f
  git add f
  git commit -m $i
done

git checkout HEAD~2
git checkout -b my-feature

for i in 6 7; do
  echo $i > f
  git add f
  git commit -m $i
done
Glucose Updated 2025-07-16
The most important on in metabolism internals, everything else gets converted to it before being processed in the .
GNOME Chess Updated 2025-07-16
The user friendly Chess UI! Exactly what you would expect from a GNOME Project package. But also packs some punch via the Universal Chess Interface, e.g. Stockfish just works.
GNU Taler Updated 2025-07-16
Centralized system that still attempts some level of privacy.
In it, a central bank issue tokens that are stored offline in your cell phone, a bit like cash bank notes.
When you take those tokens, a corresponding amount gets removed from your bank account, a bit like cash bank notes.
When a transaction is made, tokens are put into a spent token list via central API, and cannot be double spent thereafter. The corresponding ammount is then added to the bank account of the receiver. This also means that offline transactions are not possible.
When emitting, the bank signs the token with their private key. When spending, the bank checks that signature.
How do we prevent the bank from logging which token goes to which user besides trusting that they are running the software we whink they are running? Notably, couldn't timing be used to identify that?
Godlike Updated 2025-07-16
This vocabulary likely entered Ciro Santilli's vernacular through playing Counter-Strike when he was a teenager.
Good film Updated 2025-07-16

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