Deep tech Updated 2025-07-16
Ciro Santilli is a fan of this late 2010's buzzword.
It basically came about because of the endless stream of useless software startups made since the 2000's by one or two people with no investments with the continued increase in computers and Internet speeds until the great wall was reached.
Deep tech means not one of those. More specifically, it means technologies that require significant investment in expensive materials and laboratory equipment to progress, such as molecular biology technologies and quantum computing.
And it basically comes down to technologies that wrestle with the fundamental laws of physics rather than software data wrangling.
Computers are of course limited by the laws of physics, but those are much hidden by several layers of indirection.
Full visibility, and full control, make computer tasks be tasks that eventually always work out more or less as expected.
The same does not hold true when real Physics is involved.
Physics is brutal.
To start with, you can't even see your system very clearly, and often doing so requires altering its behaviour.
For example, in molecular biology, most great discoveries are made after some new technique is made to be able to observe smaller things.
But you often have to kill your cells to make those observations, which makes it very hard to understand how they work dynamically.
What we would really want would be to track every single protein as it goes about inside the cell. But that is likely an impossible dream.
The same for the brain. If we had observations of every neuron, how long would it take to understand it? Not long, people are really good at reverse engineering things when there is enough information available to do so, see also science is the reverse engineering of nature.
Then, even when you start to see the system, you might have a very hard time controlling it, because it is so fragile. This is basically the case of quantum computing in 2020.
It is for those reasons that deep tech is so exciting.
The next big things will come from deep tech. Failure is always a possibility, and you can't know before you try.
But that's also why its so fun to dare.
Stuff that Ciro Santilli considers "deep tech" as of 2020:
Deletionism on Wikipedia Updated 2025-07-16
Some examples by Ciro Santilli follow.
Of the tutorial-subjectivity type:
Notability constraints, which are are way too strict:
There are even a Wikis that were created to remove notability constraints: Wiki without notability requirements.
For these reasons reason why Ciro basically only contributes images to Wikipedia: because they are either all in or all out, and you can determine which one of them it is. And this allows images to be more attributable, so people can actually see that it was Ciro that created a given amazing image, thus overcoming Wikipedia's lack of reputation system a little bit as well.
Wikipedia is perfect for things like biographies, geography, or history, which have a much more defined and subjective expository order. But when it comes to "tutorials of how to actually do stuff", which is what mathematics and physics are basically about, Wikipedia has a very hard time to go beyond dry definitions which are only useful for people who already half know the stuff. But to learn from zero, newbies need tutorials with intuition and examples.
Bibliography:
De novo DNA synthesis Updated 2025-07-16
As of 2018, Ciro Santilli believes that this could be the next big thing in biology technology.
"De novo" means "starting from scratch", that is: you type the desired sequence into a computer, and the synthesize it.
The "de novo" part is important, because it distinguishes this from the already well solved problem of duplicating DNA from an existing DNA template, which is what all our cells do daily, and which can already be done very efficiently in vitro with polymerase chain reaction.
Notably, the dream of most of those companies is to have a machine that sits on a lab bench, which synthesises whatever you want.
TODO current de novo synthesis costs/time to delivery after ordering a custom sequence.
The initial main applications are likely going to be:
but the real pipe dream is building and bootstraping entire artificial chromosomes
News coverage:
Video 1.
Nuclera eDNA enzymatic de novo DNA synthesis explanatory animation (2021)
Source. The video shows nicely how Nuclera's enzymatic DNA synthesis works:
Lit: fish timber question answer.
The dialog is also known as allegory for an incredibly deep philosophical discussion between an idealized wise woodcutter and a fisherman, e.g. mentioned at: www2.kenyon.edu/Depts/Religion/Fac/Adler/Writings/Fisherman%20and%20Woodcutter.pdf
This song is just too slow for Ciro Santilli to make much out of it.
Figure 1.
Dialog between Fisherman and Woodcutter Chinese traditional painting by Xie Shichen
.
Video 1.
Dialog between Fisherman and Woodcutter uploaded by Fei Sun
. Source.
Video 2.
Dialog between Fisherman and Woodcutter performed by Wu Jinglüe
. Source. Accompagnied by di flute to reinforce the idea of two voices. This one has TODO year.
Dietterich Labs Updated 2025-07-16
Unfortunately the channel is too obsessed with mathematical detail (which it does amazingly), and does not give enough examples/application/intuition, which is what would be useful to most people, thus falling too much on the hardcore side of the missing link between basic and advanced.
This channel does have on merit however: compared to other university courses, it is much more direct, which might mean that you get to something interesting before you got bored to death, Section "You can learn more from older students than from faculty" comes to mind.
Videos generally involves short talks + a detailed read-through of a pre-prepared PDF. Dietterich has refused however giving the PDF or LaTeX source as of 2020 on comments unfortunately... what a wasted opportunity for society. TODO find the comment. Sam, if you ever Google yourself to this page, let's make a collab on OurBigBook.com and fucking change education forever man.
Video 1.
The Ultimate Goal Of My YouTube Channel by Dietterich Labs (2020)
Source. In this video Dietterich gives his ideal for the channel. Notably, he describes how the few experimental videos he has managed to make were done in a opportunistic way from experiments that were happening around him. This resonated with Ciro Santilli's ideas from videos of all key physics experiments.
Video 2.
Sam Dietterich interview by Dietterich Labs (2022)
Source. TODO find patience to watch and summarize key points.
Video 3.
The Sting Of Soft Corruption: My College Experience by Dietterich Labs
. Source. Academia is broken video.
DigitalDreamDoor Updated 2025-07-16
Ahh, this brings good memories of Ciro Santilli's musical formative teenage years scouring the web for the best art humanity had ever produced in certain generes. And it still is a valuable resource as of the 2020's!
Directorate of Digital Innovation (CIA) Created 2025-05-07 Updated 2025-07-16
Ciro Santilli believes that this recent directorate was likely created as a result of the massive failure of the CIA 2010 covert communication websites
Discord (software) Updated 2025-07-16
Ciro Santilli's discord ID: cirosantilli#8921. See also: how to contact Ciro Santilli.
You gotta be born after the year 2000 to understand it.
This is becoming more and more popular as a group chat with channels and threads possibility as of 2020.
Very similar to Slack.
Not possible to anonymously join just one server without creating a new account? What's the point of servers then! www.reddit.com/r/discordapp/comments/6gmjl7/changing_nick_before_joining_a_new_server/ Oh, also nicks don't hide your username from the server in any way, you can get the original username by just clicking on the person's username.
No proper threaded discussion without creating new channels? As of 2022 there is kind of a way, but it was a bit obtuse.
As of 2022 they also have a school hub: support.discord.com/hc/en-us/articles/4406046651927-Discord-Student-Hubs-FAQ which auto creates groups by university email access. Good idea, and shows popularity amongst that user group.
DNA Updated 2025-07-16
Since DNA is the centerpiece of life, Ciro Santilli is extremely excited about DNA-related technologies, see also: molecular biology technologies.
Don't be a pussy Updated 2025-09-17
!!! Survivorship bias alert !!!
quoteinvestigator.com/2018/05/07/overcome/
If you want to do something, but you are afraid to do it, then that is likely what you should do.
quoteinvestigator.com/2013/11/08/not-bend/
Don't bend; don't water it down; don't try to make it logical; don't edit your own soul according to the fashion. Rather, follow your most intense obsessions mercilessly.
www.goodreads.com/quotes/50458-whatever-you-re-meant-to-do-do-it-now-the-conditions Doris Lessing:
Whatever you're meant to do, do it now. The conditions are always impossible.
For example, when Ciro Santilli was deciding what to do in university, he wanted mostly to do pure physics.
But because he was afraid he was going to die poor and unemployed because of that, he picked engineering instead.
That was a mistake.
His family was not even poor. He was young and did not have a family to support. His father even told him: "do whatever the fuck you want, we support your decision".
But he was a coward.
It was also in part because a physicist uncle which he respected suggested that as an engineer Ciro might be able to make useful contributions to tooling required by physics. When Roberto Salmeron died in 2020, Ciro's friends shared this 2013 video interview with the late professor, where he explains he first went to the University of São Paulo to study engineering (like Ciro), but then fell for his passion for physics (like Ciro?), his first task being to build a Geiger counter, thus explaining the likely origin of the uncle's theory. But who knows, maybe he was right. Maybe Ciro's OurBigBook.com will become huge and help a lot of people, and it might not have had Ciro not done engineering and learnt programming. Destiny operates in weird ways sometimes.
Furthermore, while in University, Ciro learnt about the molecular Sciences Course of the University of São Paulo, a fantastic sounding full time course that any student could transfer to called that teaches various natural sciences topics which Ciro loves (Mathematics, Physics, Chemistry, Biology) and which students from the entire university can apply to transfer to only after joining the university, with the guarantee that they can go back to their original courses if they didn't adapt to the new course.
But did Ciro do it? Nope, he remained an even larger coward.
Had he studied more sciences, he might have been happier, and might have had greater achievements later in life, in particular when he went to École Polytechnique.
Maybe not, but now this doubt will never leave his mind until the final day.
Similar thoughts crossed his mind when he started his campaign for freedom of speech in China, but this time he had learnt the lesson, and went for it, and it felt very good.
If you have a day job, but also have a dream, and want to keep the day job for a reason, try to reserve the time of the day that your brain works best before or after work for your dream: do one cool thing every day.
Companies can help you grow because you see real problems from within them, but their end goal is to consume you as much as possible. Don't let that happen. Invest part of what you gain, in yourself. www.outsideonline.com/outdoor-adventure/paradox-going-outside/ The Paradox of Going Outside by James Somers (2012) puts it incredibly well:
I work, for instance, as a Web developer. It's a very good job. Our office is a block south of Union Square, a 12-minute commute from my apartment. We're served breakfast every morning. Our kitchen is stocked with "provisions" of organic beef jerky, coconut water, craft beers, chips, and two restaurant-class espresso machines. We have two ping pong tables and buckets of 3-star ping pong balls. (A new office manager bought "1-stars" once and some of the guys protested by crushing them.) We work on 4-cored Apple Mac computers with dual monitors. We have an unmolested hour for lunch, 10-minute breaks in the morning and afternoon, and a "do not disturb" policy past the working hours. We even have a specific email address where employees can ask for free things: genuine maple syrup, hot chocolate, a $900 chair, a new keyboard. Most of the programmers make six figures, and many of those have only three or four years of experience.
It's impossible to say so without sounding like the spokesperson for Entitlement itself but working there is still sort of soul-crushing. It's soul-crushing in the way that any job that doesn't command your full passionate attention must be. What happens is that I will be in my chair in the early afternoon and I will accidentally step out of myself and all I'll see is time passing, nine-hour parcels of healthy consciousness forever being packed away as the user experience of clerical workers or consumers or whoever gets marginally better; and I'll end up thinking that this enterprise of mine is not so much creative but bureaucratic, that what I've gotten good at is reading the instruction manuals of other people, finding my way around their insignificant warrens. And in those moments the whole business will seem to me like kind of a tragic waste.
Other quotes:
Don't be a pussy. Be a Based God
Figure 1.
Dilbert "A small brain irrationally puts more weight on a small loss than on a huge opportunity" cartoon (2000)
Source.
Figure 2.
Jake Likes Onions "Slowly" cartoon
. Source. This is what trying to reach a dream part time feels like. The cartoon reads: "The tiger pursues its prey. Slowly. The human pursues its life goals. Slowly. Very slowly.".
Video 1.
Excerpt from the documentary film "Steve Jobs: Secrets of Life" (1994)
Source.
When you grow up you tend to get told that the world is the way it is and your life is just to live your life inside the world. Try not to bash into the walls too much. Try to have a nice family life, have fun, save a little money. That's a very limited life. Life can be much broader once you discover one simple fact: Everything around you that you call life was made up by people that were no smarter than you. And you can change it, you can influence it... Once you learn that, you'll never be the same again.
Of course, survivorship bias alert!
Video 2.
What Would You Do If Money Were No Object by Alan Watts
. Source. Sample transcription: genius.com/Alan-watts-what-if-money-was-no-object-annotated:
What do you desire? What makes you itch? What sort of a situation would you like?
Let's suppose, I do this often in vocational guidance of students, they come to me and say, well, "we're getting out of college and we have the faintest idea what we want to do". So I always ask the question, "what would you like to do if money were no object? How would you really enjoy spending your life?"
Well, it's so amazing as a result of our kind of educational system, crowds of students say well, we'd like to be painters, we'd like to be poets, we'd like to be writers, but as everybody knows you can't earn any money that way. Or another person says well, I'd like to live an out-of-doors life and ride horses. I said you want to teach in a riding school?
Let's go through with it. What do you want to do? When we finally got down to something, which the individual says he really wants to do, I will say to him, you do that and forget the money, because, if you say that getting the money is the most important thing, you will spend your life completely wasting your time. You'll be doing things you don't like doing in order to go on living, that is to go on doing things you don't like doing, which is stupid. Better to have a short life that is full of what you like doing than a long life spent in a miserable way.
And after all, if you do really like what you're doing, it doesn't matter what it is, you can eventually turn it - you could eventually become a master of it. It's the only way to become a master of something, to be really with it. And then you'll be able to get a good fee for whatever it is. So don't worry too much. That's everybody is - somebody is interested in everything, anything you can be interested in, you will find others will.
But it's absolutely stupid to spend your time doing things you don't like, in order to go on spending things you don't like, doing things you don't like and to teach our children to follow in the same track. See what we are doing, is we're bringing up children and educating to live the same sort of lives we are living. In order that they may justify themselves and find satisfaction in life by bringing up their children to bring up their children to do the same thing, so it's all retch and no vomit. It never gets there. And so, therefore, it's so important to consider this question: What do I desire?
Video 3.
Keep Chargin' from a Show of Hands by Victor Wooten (1996)
Source.
That's the way I live my life, I give it my all. I think that a person should really make up his mind what he wants to do, and when did made up, he cannot fail at it. The basic rule to sucess I think, is when the going gets tough, that is a positive signal to keep chargin'.
Closely echoes Video 2. "What Would You Do If Money Were No Object by Alan Watts". Survivorship bias? Maybe. Beautiful? Unquestionably. So glad he was allowed to upload it officially to YouTube.
Video 4.
Your Life is Your life by Charles Bukowski
. Source.
Charles Bukowski is one of the most hardcore don't be a pussy people ever. It's almost scary. Far beyond Ciro level.
thebestamericanpoetry.typepad.com/the_best_american_poetry/2008/11/the-laughing-he.html
your life is your life
don't let it be clubbed into dank submission.
be on the watch.
there are ways out.
there is light somewhere.
it may not be much light but
it beats the darkness.
be on the watch.
the gods will offer you chances.
know them.
take them.
you can't beat death but
you can beat death in life, sometimes.
and the more often you learn to do it,
the more light there will be.
your life is your life.
know it while you have it.
you are marvelous
the Gods wait to delight
in you.
www.goodreads.com/quotes/39207-if-you-re-going-to-try-go-all-the-way-otherwise
If you're going to try, go all the way. Otherwise, don't even start. This could mean losing girlfriends, wives, relatives and maybe even your mind. It could mean not eating for three or four days. It could mean freezing on a park bench. It could mean jail. It could mean derision. It could mean mockery--isolation. Isolation is the gift. All the others are a test of your endurance, of how much you really want to do it. And, you'll do it, despite rejection and the worst odds. And it will be better than anything else you can imagine. If you're going to try, go all the way. There is no other feeling like that. You will be alone with the Gods, and the nights will flame with fire. You will ride life straight to perfect laughter. It's the only good fight there is.
I have one of two choices - stay in the post office and go crazy... or stay out here and play at writer and starve. I have decided to starve.
Figure 3.
Bukowski kissing his typewriter.
Like Ciro Santilli and his computer!
Video 5.
All adults are bored scene from an Edward Teller, An Early Time
. Source.
Up to the time that I met Klug ([a mathematiciam]), I was sure that all grown ups were people to be pitied. They had to work, they were tired, they were bored with what they were doing. I heard both my parents often complain. Klug was the first man whom I met who most obviously enoyed what he was doing.
But to be fair, being a fucking "genius" might be a requirement to escape that fate!
Figure 4.
Modern Sisyphus by Sephko
. Source.
Video 6.
"I just stopped thinking" scene from Malcolm in the Middle S05E21 "Reese Joins The Army"
. Source. Working in most big companies can feel like this sometimes. We need stronger AI (AGI?) to help wipe out this boredom. A anti-AGI blues moment for you.
Figure 5.
Do epic shit meme
. Source.
Do epic shit
Unless you are too tired, or it costs too much money, in which case, Do affordable shit, and make time for naps
Video 7.
Roy: A Life Well Lived scene from Rick and Morty S02E02
. Source.
Drake (robotics software) Updated 2025-07-16
The Robotics team at TRI is working hard to close the gap between simulation and reality. For manipulation, one important piece is accurate simulation of rigid-body contact.