Deep tech Updated 2025-07-16
It basically came about because of the endless stream of useless software startups made since the 2000's by one or two people with no investments with the continued increase in computers and Internet speeds until the great wall was reached.
Deep tech means not one of those. More specifically, it means technologies that require significant investment in expensive materials and laboratory equipment to progress, such as molecular biology technologies and quantum computing.
And it basically comes down to technologies that wrestle with the fundamental laws of physics rather than software data wrangling.
Computers are of course limited by the laws of physics, but those are much hidden by several layers of indirection.
Full visibility, and full control, make computer tasks be tasks that eventually always work out more or less as expected.
The same does not hold true when real Physics is involved.
Physics is brutal.
To start with, you can't even see your system very clearly, and often doing so requires altering its behaviour.
For example, in molecular biology, most great discoveries are made after some new technique is made to be able to observe smaller things.
But you often have to kill your cells to make those observations, which makes it very hard to understand how they work dynamically.
What we would really want would be to track every single protein as it goes about inside the cell. But that is likely an impossible dream.
The same for the brain. If we had observations of every neuron, how long would it take to understand it? Not long, people are really good at reverse engineering things when there is enough information available to do so, see also science is the reverse engineering of nature.
Then, even when you start to see the system, you might have a very hard time controlling it, because it is so fragile. This is basically the case of quantum computing in 2020.
The next big things will come from deep tech. Failure is always a possibility, and you can't know before you try.
But that's also why its so fun to dare.
Stuff that Ciro Santilli considers "deep tech" as of 2020:
- brain-computer interface
- fusion power. The question there is, when is "deep", "too deep"?
Deletionism on Wikipedia Updated 2025-07-16
Some examples by Ciro Santilli follow.
Of the tutorial-subjectivity type:
- This edit perfectly summarizes how Ciro feels about Wikipedia (no particular hate towards that user, he was a teacher at the prestigious Pierre and Marie Curie University and actually as a wiki page about him):which removed the only diagram that was actually understandable to non-Mathematicians, which Ciro Santilli had created, and received many upvotes at: math.stackexchange.com/questions/776039/intuition-behind-normal-subgroups/3732426#3732426. The removal does not generate any notifications to you unless you follow the page which would lead to infinite noise, and is extremely difficult to find out how to contact the other person. The removal justification is even somewhat ad hominem: how does he know Ciro Santilli is also not a professional Mathematician? :-) Maybe it is obvious because Ciro explains in a way that is understandable. Also removal makes no effort to contact original author. Of course, this is caused by the fact that there must also have been a bunch of useless edits not done by Ciro, and there is no reputation system to see if you should ignore a person or not immediately, so removal author has no patience anymore. This is what makes it impossible to contribute to Wikipedia: your stuff gets deleted at any time, and you don't know how to appeal it. Ciro is going to regret having written this rant after Daniel replies and shows the diagram is crap. But that would be better than not getting a reply and not learning that the diagram is crap.
rm a cryptic diagram (not understandable by a professional mathematician, without further explanations
- en.wikipedia.org/w/index.php?title=Finite_field&type=revision&diff=1044934168&oldid=1044905041 on finite fields with edit comment "Obviously: X ≡ α". Discussion at en.wikipedia.org/wiki/Talk:Finite_field#Concrete_simple_worked_out_example Some people simply don't know how to explain things to beginners, or don't think Wikipedia is where it should be done. One simply can't waste time fighting off those people, writing good tutorials is hard enough in itself without that fight.
- en.wikipedia.org/w/index.php?title=Discrete_Fourier_transform&diff=1193622235&oldid=1193529573 by user Bob K. removed Ciro Santilli's awesome simple image of the Discrete Fourier transform as seen at en.wikipedia.org/w/index.php?title=Discrete_Fourier_transform&oldid=1176616763:with message:
Hello. I am a retired electrical engineer, living near Washington,DC. Most of my contributions are in the area of DSP, where I have about 40 years of experience in applications on many different processors and architectures.
Thank you so much!!remove non-helpful image
Maybe it is a common thread that these old "experts" keep removing anything that is actually intelligible by beginners? Section "There is value in tutorials written by beginners"Also ranted at: x.com/cirosantilli/status/1808862417566290252Figure 1. Source at: numpy/fft_plot.py. - when Ciro Santilli created Scott Hassan's page, he originally included mentions of his saucy divorce: en.wikipedia.org/w/index.php?title=Scott_Hassan&oldid=1091706391 These were reverted by Scott's puppets three times, and Ciro and two other editors fought back. Finally, Ciro understood that Hassan's puppets were likely right about the removal because you can't talk about private matters of someone who is low profile:even if it is published in well known and reliable publications like the bloody New York Times. In this case, it is clear that most people wanted to see this information summarized on Wikipedia since others fought back Hassan's puppet. This is therefore a failure of Wikipedia to show what the people actually want to read about.This case is similar to the PsiQuantum one. Something is extremely well known in an important niche, and many people want to read about it. But because the average person does not know about this important subject, and you are limited about what you can write about it or not, thus hurting the people who want to know about it.
Notability constraints, which are are way too strict:There are even a Wikis that were created to remove notability constraints: Wiki without notability requirements.
- even information about important companies can be disputed. E.g. once Ciro Santilli tried to create a page for PsiQuantum, a startup with $650m in funding, and there was a deletion proposal because it did not contain verifiable sources not linked directly to information provided by the company itself: en.wikipedia.org/wiki/Wikipedia:Articles_for_deletion/PsiQuantum Although this argument is correct, it is also true about 90% of everything that is on Wikipedia about any company. Where else can you get any information about a B2B company? Their clients are not going to say anything. Lawsuits and scandals are kind of the only possible source... In that case, the page was deleted with 2 votes against vs 3 votes for deletion.is very similar to Stack Exchange's own Stack Overflow content deletion issues. Ain't Nobody Got Time For That. "Ain't Nobody Got Time for That" actually has a Wiki page: en.wikipedia.org/wiki/Ain%27t_Nobody_Got_Time_for_That. That's notable. Unlike a $600M+ company of course.
should we delete this extremely likely useful/correct content or not according to this extremely complex system of guidelines"
In December 2023 the page was re-created, and seemed to stick: en.wikipedia.org/wiki/Talk:PsiQuantum#Secondary_sources It's just a random going back and forth. Author Ctjk has an interesting background:I am a legal official at a major government antitrust agency. The only plausible connection is we regulate tech firms
For these reasons reason why Ciro basically only contributes images to Wikipedia: because they are either all in or all out, and you can determine which one of them it is. And this allows images to be more attributable, so people can actually see that it was Ciro that created a given amazing image, thus overcoming Wikipedia's lack of reputation system a little bit as well.
Wikipedia is perfect for things like biographies, geography, or history, which have a much more defined and subjective expository order. But when it comes to "tutorials of how to actually do stuff", which is what mathematics and physics are basically about, Wikipedia has a very hard time to go beyond dry definitions which are only useful for people who already half know the stuff. But to learn from zero, newbies need tutorials with intuition and examples.
Bibliography:
- gwern.net/inclusionism from gwern.net:
Iron Law of Bureaucracy: the downwards deletionism spiral discourages contribution and is how Wikipedia will die.
- Quote "Golden wiki vs Deletionism on Wikipedia"
De novo DNA synthesis Updated 2025-07-16
"De novo" means "starting from scratch", that is: you type the desired sequence into a computer, and the synthesize it.
The "de novo" part is important, because it distinguishes this from the already well solved problem of duplicating DNA from an existing DNA template, which is what all our cells do daily, and which can already be done very efficiently in vitro with polymerase chain reaction.
Notably, the dream of most of those companies is to have a machine that sits on a lab bench, which synthesises whatever you want.
The initial main applications are likely going to be:but the real pipe dream is building and bootstraping entire artificial chromosomes
- polymerase chain reaction primers (determine which region will be amplified
- creating a custom sequence to be inserted in a plasmid, i.e. artificial gene synthesis
News coverage:
Nuclera eDNA enzymatic de novo DNA synthesis explanatory animation (2021)
Source. The video shows nicely how Nuclera's enzymatic DNA synthesis works:- they provide blocked nucleotides of a single type
- add them with the enzyme. They use a werid DNA polymerase called terminal deoxynucleotidyl transferase that adds a base at a time to a single stranded DNA strand rather than copying from a template
- wash everything
- do deblocking reaction
- and then repeat until done
Dialog between Fisherman and Woodcutter Updated 2025-07-16
Lit: fish timber question answer.
The dialog is also known as allegory for an incredibly deep philosophical discussion between an idealized wise woodcutter and a fisherman, e.g. mentioned at: www2.kenyon.edu/Depts/Religion/Fac/Adler/Writings/Fisherman%20and%20Woodcutter.pdf
This song is just too slow for Ciro Santilli to make much out of it.
Bibliography:
Dialog between Fisherman and Woodcutter Chinese traditional painting by Xie Shichen
. Dietterich Labs Updated 2025-07-16
Covers some specific hardcore subjects, notably quantum electrodynamics, in full mathematical detail, e.g.: "Quantum Field Theory Lecture Series" playlist: www.youtube.com/playlist?list=PLSpklniGdSfSsk7BSZjONcfhRGKNa2uou
As of 2020 Dietterich was a condensed matter PhD candidate or post-doc at the University of Minnesota Twin Cities, and he lives in Minnesota, sources:
Unfortunately the channel is too obsessed with mathematical detail (which it does amazingly), and does not give enough examples/application/intuition, which is what would be useful to most people, thus falling too much on the hardcore side of the missing link between basic and advanced.
This channel does have on merit however: compared to other university courses, it is much more direct, which might mean that you get to something interesting before you got bored to death, Section "You can learn more from older students than from faculty" comes to mind.
Videos generally involves short talks + a detailed read-through of a pre-prepared PDF. Dietterich has refused however giving the PDF or LaTeX source as of 2020 on comments unfortunately... what a wasted opportunity for society. TODO find the comment. Sam, if you ever Google yourself to this page, let's make a collab on OurBigBook.com and fucking change education forever man.
The Ultimate Goal Of My YouTube Channel by Dietterich Labs (2020)
Source. In this video Dietterich gives his ideal for the channel. Notably, he describes how the few experimental videos he has managed to make were done in a opportunistic way from experiments that were happening around him. This resonated with Ciro Santilli's ideas from videos of all key physics experiments.Sam Dietterich interview by Dietterich Labs (2022)
Source. TODO find patience to watch and summarize key points.The Sting Of Soft Corruption: My College Experience by Dietterich Labs
. Source. Academia is broken video. DigitalDreamDoor Updated 2025-07-16
Directorate of Digital Innovation (CIA) Created 2025-05-07 Updated 2025-07-16
Ciro Santilli believes that this recent directorate was likely created as a result of the massive failure of the CIA 2010 covert communication websites
Discord (software) Updated 2025-07-16
You gotta be born after the year 2000 to understand it.
This is becoming more and more popular as a group chat with channels and threads possibility as of 2020.
Very similar to Slack.
They force your username to have 4 random digits? www.reddit.com/r/discordapp/comments/43kjdl/whats_the_number_next_to_the_username/
Not possible to anonymously join just one server without creating a new account? What's the point of servers then! www.reddit.com/r/discordapp/comments/6gmjl7/changing_nick_before_joining_a_new_server/ Oh, also nicks don't hide your username from the server in any way, you can get the original username by just clicking on the person's username.
No proper threaded discussion without creating new channels? As of 2022 there is kind of a way, but it was a bit obtuse.
As of 2022 they also have a school hub: support.discord.com/hc/en-us/articles/4406046651927-Discord-Student-Hubs-FAQ which auto creates groups by university email access. Good idea, and shows popularity amongst that user group.
Servers don't have an ID to join them? www.reddit.com/r/discordapp/comments/b9zdt6/join_discord_server_from_id/
Can only make public servers if you have 1000 members?? support.discord.com/hc/en-us/articles/360023968311 Why so much bullshit?? www.reddit.com/r/discordapp/comments/6jouf8/how_do_i_make_my_server_public/
DNA Updated 2025-07-16
Since DNA is the centerpiece of life, Ciro Santilli is extremely excited about DNA-related technologies, see also: molecular biology technologies.
Dojo learning model Updated 2025-07-16
Don't be a pussy Updated 2025-09-17
!!! Survivorship bias alert !!!
quoteinvestigator.com/2018/05/07/overcome/
If you want to do something, but you are afraid to do it, then that is likely what you should do.
www.goodreads.com/quotes/50458-whatever-you-re-meant-to-do-do-it-now-the-conditions Doris Lessing:
Whatever you're meant to do, do it now. The conditions are always impossible.
For example, when Ciro Santilli was deciding what to do in university, he wanted mostly to do pure physics.
But because he was afraid he was going to die poor and unemployed because of that, he picked engineering instead.
That was a mistake.
His family was not even poor. He was young and did not have a family to support. His father even told him: "do whatever the fuck you want, we support your decision".
But he was a coward.
It was also in part because a physicist uncle which he respected suggested that as an engineer Ciro might be able to make useful contributions to tooling required by physics. When Roberto Salmeron died in 2020, Ciro's friends shared this 2013 video interview with the late professor, where he explains he first went to the University of São Paulo to study engineering (like Ciro), but then fell for his passion for physics (like Ciro?), his first task being to build a Geiger counter, thus explaining the likely origin of the uncle's theory. But who knows, maybe he was right. Maybe Ciro's OurBigBook.com will become huge and help a lot of people, and it might not have had Ciro not done engineering and learnt programming. Destiny operates in weird ways sometimes.
Furthermore, while in University, Ciro learnt about the molecular Sciences Course of the University of São Paulo, a fantastic sounding full time course that any student could transfer to called that teaches various natural sciences topics which Ciro loves (Mathematics, Physics, Chemistry, Biology) and which students from the entire university can apply to transfer to only after joining the university, with the guarantee that they can go back to their original courses if they didn't adapt to the new course.
But did Ciro do it? Nope, he remained an even larger coward.
Had he studied more sciences, he might have been happier, and might have had greater achievements later in life, in particular when he went to École Polytechnique.
Similar thoughts crossed his mind when he started his campaign for freedom of speech in China, but this time he had learnt the lesson, and went for it, and it felt very good.
If you have a day job, but also have a dream, and want to keep the day job for a reason, try to reserve the time of the day that your brain works best before or after work for your dream: do one cool thing every day.
Companies can help you grow because you see real problems from within them, but their end goal is to consume you as much as possible. Don't let that happen. Invest part of what you gain, in yourself. www.outsideonline.com/outdoor-adventure/paradox-going-outside/ The Paradox of Going Outside by James Somers (2012) puts it incredibly well:
I work, for instance, as a Web developer. It's a very good job. Our office is a block south of Union Square, a 12-minute commute from my apartment. We're served breakfast every morning. Our kitchen is stocked with "provisions" of organic beef jerky, coconut water, craft beers, chips, and two restaurant-class espresso machines. We have two ping pong tables and buckets of 3-star ping pong balls. (A new office manager bought "1-stars" once and some of the guys protested by crushing them.) We work on 4-cored Apple Mac computers with dual monitors. We have an unmolested hour for lunch, 10-minute breaks in the morning and afternoon, and a "do not disturb" policy past the working hours. We even have a specific email address where employees can ask for free things: genuine maple syrup, hot chocolate, a $900 chair, a new keyboard. Most of the programmers make six figures, and many of those have only three or four years of experience.It's impossible to say so without sounding like the spokesperson for Entitlement itself but working there is still sort of soul-crushing. It's soul-crushing in the way that any job that doesn't command your full passionate attention must be. What happens is that I will be in my chair in the early afternoon and I will accidentally step out of myself and all I'll see is time passing, nine-hour parcels of healthy consciousness forever being packed away as the user experience of clerical workers or consumers or whoever gets marginally better; and I'll end up thinking that this enterprise of mine is not so much creative but bureaucratic, that what I've gotten good at is reading the instruction manuals of other people, finding my way around their insignificant warrens. And in those moments the whole business will seem to me like kind of a tragic waste.
Other quotes:
- is a phrase Sergey Brin uses. The Google Story claims he picked that up from academia, and quotes this from a september 2003 talk in an Israeli elite high school.
Healthy Disregard For The Impossible
- quoteinvestigator.com/2014/05/29/find-love/
Find What You Love and Let It Kill You
- Cute boy things by Caroline Ellison:
if you are a boy with the confidence to advocate for unconventional ideas and take actions based on them you are valid
- How can I be as great by Justine Musk:
rock the boat
- From the 1922 poem Portuguese Sea by famous Portuguese poet Fernando Pessoa, which gets drilled into the head of every Brazilian high school student:He who wants to pass beyond the Bojador
Must go beyond pain.Quem quer passar além do Bojador
Tem que passar além da dor. - Translation of a poem by Muhammad Iqbal TODO date:One is reminded of As iron sharpens iron, so one person sharpens another.
- "NPC life" as a way to refer to a soul crushing job
- twitter.com/0xTenkito/status/1775167216641548732, a cryptocurrency investor says:However there is one thing to lose, if you do safer investments and don't lose everything, then you might be able to retire earlier.
- archive.ph/mlaLK
- twitter.com/0xTenkito/status/1775167216641548732, a cryptocurrency investor says:
Dilbert "A small brain irrationally puts more weight on a small loss than on a huge opportunity" cartoon (2000)
Source. Jake Likes Onions "Slowly" cartoon
. Source. This is what trying to reach a dream part time feels like. The cartoon reads: "The tiger pursues its prey. Slowly. The human pursues its life goals. Slowly. Very slowly.".Excerpt from the documentary film "Steve Jobs: Secrets of Life" (1994)
Source. When you grow up you tend to get told that the world is the way it is and your life is just to live your life inside the world. Try not to bash into the walls too much. Try to have a nice family life, have fun, save a little money. That's a very limited life. Life can be much broader once you discover one simple fact: Everything around you that you call life was made up by people that were no smarter than you. And you can change it, you can influence it... Once you learn that, you'll never be the same again.
Of course, survivorship bias alert!
What Would You Do If Money Were No Object by Alan Watts
. Source. Sample transcription: genius.com/Alan-watts-what-if-money-was-no-object-annotated:What do you desire? What makes you itch? What sort of a situation would you like?Let's suppose, I do this often in vocational guidance of students, they come to me and say, well, "we're getting out of college and we have the faintest idea what we want to do". So I always ask the question, "what would you like to do if money were no object? How would you really enjoy spending your life?"Well, it's so amazing as a result of our kind of educational system, crowds of students say well, we'd like to be painters, we'd like to be poets, we'd like to be writers, but as everybody knows you can't earn any money that way. Or another person says well, I'd like to live an out-of-doors life and ride horses. I said you want to teach in a riding school?Let's go through with it. What do you want to do? When we finally got down to something, which the individual says he really wants to do, I will say to him, you do that and forget the money, because, if you say that getting the money is the most important thing, you will spend your life completely wasting your time. You'll be doing things you don't like doing in order to go on living, that is to go on doing things you don't like doing, which is stupid. Better to have a short life that is full of what you like doing than a long life spent in a miserable way.And after all, if you do really like what you're doing, it doesn't matter what it is, you can eventually turn it - you could eventually become a master of it. It's the only way to become a master of something, to be really with it. And then you'll be able to get a good fee for whatever it is. So don't worry too much. That's everybody is - somebody is interested in everything, anything you can be interested in, you will find others will.But it's absolutely stupid to spend your time doing things you don't like, in order to go on spending things you don't like, doing things you don't like and to teach our children to follow in the same track. See what we are doing, is we're bringing up children and educating to live the same sort of lives we are living. In order that they may justify themselves and find satisfaction in life by bringing up their children to bring up their children to do the same thing, so it's all retch and no vomit. It never gets there. And so, therefore, it's so important to consider this question: What do I desire?
Keep Chargin' from a Show of Hands by Victor Wooten (1996)
Source. That's the way I live my life, I give it my all. I think that a person should really make up his mind what he wants to do, and when did made up, he cannot fail at it. The basic rule to sucess I think, is when the going gets tough, that is a positive signal to keep chargin'.
Charles Bukowski is one of the most hardcore don't be a pussy people ever. It's almost scary. Far beyond Ciro level.
thebestamericanpoetry.typepad.com/the_best_american_poetry/2008/11/the-laughing-he.html
your life is your life
don't let it be clubbed into dank submission.
be on the watch.
there are ways out.
there is light somewhere.
it may not be much light but
it beats the darkness.
be on the watch.
the gods will offer you chances.
know them.
take them.
you can't beat death but
you can beat death in life, sometimes.
and the more often you learn to do it,
the more light there will be.
your life is your life.
know it while you have it.
you are marvelous
the Gods wait to delight
in you.
www.goodreads.com/quotes/39207-if-you-re-going-to-try-go-all-the-way-otherwise
If you're going to try, go all the way. Otherwise, don't even start. This could mean losing girlfriends, wives, relatives and maybe even your mind. It could mean not eating for three or four days. It could mean freezing on a park bench. It could mean jail. It could mean derision. It could mean mockery--isolation. Isolation is the gift. All the others are a test of your endurance, of how much you really want to do it. And, you'll do it, despite rejection and the worst odds. And it will be better than anything else you can imagine. If you're going to try, go all the way. There is no other feeling like that. You will be alone with the Gods, and the nights will flame with fire. You will ride life straight to perfect laughter. It's the only good fight there is.
I have one of two choices - stay in the post office and go crazy... or stay out here and play at writer and starve. I have decided to starve.
Bukowski kissing his typewriter.
Like Ciro Santilli and his computer!All adults are bored scene from an Edward Teller, An Early Time
. Source. Up to the time that I met Klug ([a mathematiciam]), I was sure that all grown ups were people to be pitied. They had to work, they were tired, they were bored with what they were doing. I heard both my parents often complain. Klug was the first man whom I met who most obviously enoyed what he was doing.
"I just stopped thinking" scene from Malcolm in the Middle S05E21 "Reese Joins The Army"
. Source. Working in most big companies can feel like this sometimes. We need stronger AI (AGI?) to help wipe out this boredom. A anti-AGI blues moment for you. Drake (robotics software) Updated 2025-07-16
TRI means Toyota Research Institute BTW.
The Robotics team at TRI is working hard to close the gap between simulation and reality. For manipulation, one important piece is accurate simulation of rigid-body contact.
Dream Updated 2025-07-16


