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Concerted oxygen transfer from a peroxycarboxylic acid to an alkene. Hydrogen bonding to a nearby alcohol can influence reaction site and facial selectivity.
The simplest epoxide, a three-membered ring. Opening by a carbon nucleophile, followed by protonation, adds a two-carbon primary-alcohol unit.
Epitope mapping investigates which target regions or residues contribute to recognition by an antibody. Loss of binding after a target mutation must be distinguished from target misfolding or loss of expression.
epidermis between hair follicles. Its renewal dynamics and lineage contributions vary with anatomical site and injury context.
An extraembryonic syncytial domain in teleost embryos that generates forces and signalling inputs affecting gastrulation.
A superficial epithelial cell layer of the zebrafish embryo that spreads over the yolk during epiboly.
A time course with rapid initial formation of a measured reaction product, followed by slower steady-state turnover. It can reveal fast initial chemistry followed by slow regeneration of competent enzyme; the monitored product and mixing time resolution are essential to interpretation.
Catalytic cycles per unit time per active enzyme site under defined saturating conditions. In the corresponding simple model, .
For simple Michaelis–Menten kinetics at low substrate concentration, . This efficiency combines productive substrate capture and turnover; it should be interpreted with the assay conditions and mechanism.
Rapid mixing followed by time-resolved observation, commonly by fluorescence or absorbance. A signal change must be assigned through a kinetic model rather than automatically equated with chemistry.
Measurement of early reaction behaviour before a steady-state distribution of enzyme intermediates is established. Bursts and lags can separate fast chemical conversion from slower steps.
The Entringer triangle arranges Entringer numbers into rows. Each row is obtained from reversed-row prefix sums, with the boundary convention specified by the recurrence.
Conjugate reduction followed by carbon-electrophile trapping of the resulting enolate. The original enone alpha position determines the alkylation site before any later equilibration.
An enol carbonate is an enol derivative whose oxygen bears a carbonate ester group, represented schematically by . The enol-derived carbon-carbon double bond and the carbonate group are both part of its reactivity.
Masking an enol as a derivative allows its structure and reactions to be controlled separately from those of the parent carbonyl compound. The exact substitution pattern therefore matters when using an enol carbonate in synthesis.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact