The "Three Wise Men" refers to a group of three volcanic mountains located in the Caribbean, specifically on the island of Saint Lucia. These volcanoes are named: 1. **Mount Gros Piton** 2. **Mount Petit Piton** 3. **Soufrière Volcano** The "Three Wise Men" are well-known for their striking appearances and their roles in the landscape of Saint Lucia.

Tourmaline Reef is a popular surf spot located in La Jolla, California, known for its consistent waves and picturesque setting. It is part of La Jolla's coastline and attracts surfers, paddleboarders, and marine life enthusiasts. The reef is named for the colorful tourmaline gemstones that can sometimes be found in the area. The spot is characterized by its relatively shallow waters and often provides suitable conditions for both beginners and experienced surfers, depending on the swell and tide.

Wedi Ireng Beach is a scenic beach located in the eastern part of Indonesia, specifically on the island of Java in the region of Banyuwangi. It is known for its stunning natural beauty, featuring fine white sand, clear blue waters, and lush green hills surrounding the area. The beach is often praised for its picturesque landscapes, making it a popular destination for both local and international tourists.

Yuryaku Seamount is an underwater mountain located in the northwestern Pacific Ocean, part of the volcanic arc system associated with the Kamchatka Peninsula and the Kuril Islands. It is one of several seamounts in the region, which are often formed by volcanic activity. Seamounts like Yuryaku are significant for marine biodiversity, as they provide habitats for various marine organisms and can influence local ocean currents and ecosystems.

Lanai is the sixth-largest island in Hawaii and is known for its stunning natural beauty, luxury resorts, and relatively low population density. Often referred to as the "Pineapple Island," Lanai was formerly a major producer of pineapples, with a significant portion of its economy based on pineapple cultivation until the late 20th century. The island features diverse landscapes, including rugged volcanic terrain, lush rainforests, and beautiful beaches.

Maro Reef is a marine protected area located off the coast of the province of Granada in Spain. It is situated near the town of Maro, which is part of the municipality of Nerja. The reef is known for its rich biodiversity, including various species of fish, corals, and other marine life. The area also features underwater caves and cliffs, making it a popular spot for activities such as snorkeling and diving.

Bestrophin 1 (BEST1) is a protein that is encoded by the BEST1 gene in humans. It is primarily expressed in retinal cells, particularly in the retinal pigment epithelium (RPE), and plays an important role in the function of the retina. Bestrophin 1 is believed to be involved in the regulation of ion channels, particularly chloride channels, and is thought to have a role in maintaining the ionic balance and fluid homeostasis in the eye.

CACNA2D3 is a gene that encodes the alpha-2/delta-3 subunit of voltage-gated calcium channels. These channels are critical for various physiological processes, including muscle contraction, neurotransmitter release, and other signal transduction pathways. The alpha-2/delta subunits play a role in the trafficking, expression, and regulation of the calcium channels.

GABRA3 is a gene that encodes the gamma-aminobutyric acid (GABA) type A receptor subunit alpha3. GABA receptors are the major inhibitory neurotransmitter receptors in the central nervous system (CNS) and play a crucial role in regulating neuronal excitability and synaptic transmission. The GABRA3 protein is part of the pentameric structure that forms the GABA A receptor, which consists of five subunits.

HCN2 refers to a member of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channel family, specifically the HCN2 gene that encodes for the HCN2 protein. HCN channels are ion channels that allow the selective passage of sodium (Na⁺) and potassium (K⁺) ions across cell membranes.

KCNA2 (Potassium Voltage-Gated Channel Subfamily A Member 2) is a gene that encodes a protein known as a voltage-gated potassium channel. These channels play a crucial role in maintaining the electrical excitability of cells, particularly in neurons and muscle cells. The KCNA2 protein is involved in repolarizing the membrane potential after an action potential, helping to regulate the flow of potassium ions across the cell membrane.

KcsA is a potassium ion (K⁺) channel derived from the bacterium *Streptomyces lividans*. It is one of the first potassium channels to be structurally characterized, providing significant insights into the mechanism of ion selectivity and channel function in biological systems. KcsA is a homotetrameric protein, meaning it is composed of four identical subunits that together form a central pore through which potassium ions can pass.

LRRC8B (Leucine-Rich Repeat Containing 8 Isoform B) is a protein that is part of the LRRC8 family of proteins, which are known to form channels in cell membranes. These channels are important for the transport of various molecules across cell membranes, particularly small metabolites, ions, and water. LRRC8B is specifically involved in forming volume-regulated anion channels (VRACs), which are related to cell volume regulation.

P2RX1, or purinergic receptor P2X, ligand-gated ion channel 1, is a gene that encodes a protein which is part of the P2X receptor family. These receptors are activated by extracellular ATP and are known to function as ion channels that facilitate the passage of ions such as sodium, potassium, and calcium across cell membranes. P2RX1 is involved in various physiological processes, including neurotransmission, pain sensation, inflammation, and immune responses.

P2RX6, or purinergic receptor P2X 6, is a gene that encodes a protein belonging to the purinergic receptor family. Specifically, it is a member of the P2X receptor group, which are ionotropic receptors activated by extracellular ATP (adenosine triphosphate). These receptors are involved in various physiological processes, including neurotransmission, muscle contraction, and the regulation of blood flow.

SCN2B is a gene that encodes the beta subunit of type II voltage-gated sodium channels. These channels play a crucial role in the generation and propagation of action potentials in neurons and other excitable tissues. The beta subunits, including those encoded by the SCN2B gene, are essential for the proper functioning and regulation of the alpha subunit (the main component) of sodium channels.

TPCN2, or "Two-Pore Channel 2," is a gene that encodes a protein belonging to the family of two-pore channels, which are involved in the transport of ions across cell membranes. This protein specifically functions as a ion channel that selectively allows the passage of calcium ions (Ca²⁺) and other cations.

Nuclear Magnetic Resonance (NMR) experiments are analytical techniques used to observe the magnetic properties of atomic nuclei. The technique exploits the magnetic properties of certain nuclei to provide detailed information about the structure, dynamics, and environment of molecules.

The Athinoula A. Martinos Center for Biomedical Imaging is a research facility affiliated with Massachusetts General Hospital and Harvard Medical School. It is known for its pioneering work in the field of biomedical imaging and neuroscience. The center focuses on developing and applying innovative imaging techniques to study the brain and other biological systems, combining various modalities like magnetic resonance imaging (MRI), functional MRI (fMRI), and magnetoencephalography (MEG).

Magnetization transfer is a phenomenon observed in magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) spectroscopy. It involves the transfer of magnetization from one pool of protons (nuclei) to another, typically between freely moving (mobile) protons and those that are closely bound within macromolecules or in less mobile environments. In MRI, magnetization transfer is utilized to enhance contrast between different tissues.