Angiotensin-converting enzyme 2 Updated +Created
UniProt human: www.uniprot.org/uniprot/Q9BYF1 It is interesting to see in the Mutagenesis how many known mutations can increase or decrease SARS-CoV-2 S protein binding affinity.
Australopithecine Updated +Created
This is the level at which human and all extinct siblings lie, with no other extant species, all others were killed or fucked to death: Section "Interbreeding between archaic and modern humans".
Ciro Santilli Updated +Created
Ciro Santilli is a male human software engineer and activist born in Brazil, Earth in 1989 AD.
Quick facts:
Other people with the same name are listed at Section "Ciro Santilli's homonyms".
Figure 1.
19th century illustration of the Journey to the West protagonist Sun Wukong
. Source.
Sun Wukong (孙悟空) is a playful and obscenely powerful monkey Journey to the West. He protects Buddhist monk Tang Sanzang, and likes eating fruit, just like Ciro. Oh, and Goku from Dragon Ball is based on him. His japanese name is "Sun Wukong" (same Chinese characters with different Japanese pronunciation) for the love. His given name "Wukong" means literally "the one who mastered the void", which is clearly a Dharma name and fucking awesome in multiple ways. This is another sad instance of a Chinese thing better known in the West as Japanese.
It is worth noting however that although Wukong is extremely charming, Ciro's favorite novel of the Four Great Classic Novels is Water Margin. Journey to the West is just a Monster of the Week for kids, but Water Margin is a fight for justice saga. Sorry Wukong!
Figure 2.
Ciro Santilli playing with a pipette at the University of Cambridge circa 2017
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The photo was taken in an open event organized by the awesome Cambridge Synthetic Biology outreach group, more or less the same people who organize: www.meetup.com/Cambridge-Synthetic-Biology-Meetup/ and who helped organize Section "How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it".
Taking part in such activities is what Ciro tries to do to overcome his lifelong regret of not having done more experimental stuff at university. Would he have had the patience to handle all the bullshit of the physical word without going back to the informational sciences? Maybe, maybe not. But now he will probably never know?!
Notice the orange high visibility cycling jersey under the lab coat, from someone who had just ridden in from work as fast as possible as part of his "lunch break". It is more fun when it is hard.
Figure 3.
Scribe Jean Miélot, 15th century
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Ciro Santilli fantasises that he would have make a good scribe in the middle ages, partly due to his self diagnosed graphomania, but also appreciation for foreign languages, and his mild obsession with the natural sciences.
OurBigBook.com is Ciro's view of a modern day scriptorium, except that now the illuminations are YouTube videos.
Chill and eat your bread in peace comes to mind. A scribe, in a library, reading and writing the entire day in peace and quiet. The life!
The job of a Internet-age scribe is basically that of making knowledge more open, legally extracting it from closed copyrighted sources, and explaining your understanding of it to the wider world under Creative Commons licenses on the web. And in the process of greater openess, given a well organized system, we are able combine the knowledge of many diffferent people, and thus make things more understandable than any single/few creator closed source source could ever achieve.
Ciro once saw some cartoon on Wikipedia help pages of a turtle with a book in one hand, and typing into Wikipedia on its computer, TODO find it. That cartoon summarizes well the modern scribe life.
Another analogous version of this fantasy more in touch with Ciro's sinophily is the ideal of the Chinese scholar, notably including their stereotypical attributes such as mastery of the Four arts.
Figure 4.
Ciro Santilli piling boxes as a child
. A natural born engineer.
Human brain Updated +Created
The brain of a human.
Ciro Santilli feels it is not for his generation though, and that is one of the philosophical things that saddens him the most in this world.
On the other hand, Ciro's playing with the Linux kernel and other complex software which no single human can every fully understand cheer him up a bit. But still, the high level view, that we can have...
Figure 1. Source.
  • 1: Ventriculus lateralis, Cornu frontale
  • 2: Ventriculus lateralis, Pars centralis
  • 3: Calcar avis
  • 4: Ventriculus lateralis, Cornu occipitale
  • 5: Trigonum collaterale
  • 6: Eminentia collateralis
  • 7: Hippocampus
  • 8: Ventriculus lateralis, Cornu temporale
  • 9: Capsula interna
  • 10: Nucleus caudatus
Key mitochondrial proteins aren't necessarily in mtDNA Updated +Created
E.g. in humans the adenine nucleotide translocator is present in chromosome 4, not in mtDNA.
These have almost certainly been transferred to nuclear DNA in the course of evolution.
This isn't completely surprising, since when mitochondria die, their DNA is kind of left in the cell, so it is not hard to imagine how genes end up getting uptaken by the nucleus. This is suggested at Power, Sex, Suicide by Nick Lane (2006) page 196.
A limiting factor appears to be that you can't just past those genes in the nucleus, further mutations are necessary for mitochondrial protein import to work, apparenty some kind of tagging with extra amino acids.
However, you likely don't want to remove all genes from the mitochondria because mitochondria have DNA because they need to be controlled individually.
Marc Verdiell Updated +Created
Marc Verdiell is a human electrical engineer best known for being the creator and host of the CuriousMarc YouTube channel.
Marc made $58.4m from the sale of LightLogic, an optoelectronics company he founded, to Intel in 2001:
Figure 1. . Source. Location inferred from Marc's videos', but likely, he often frequents the place, and it looks a bit like that.
Video 1.
Profile of Marc Verdiell by Gizmodo (2018)
Source.
youtu.be/tJ2-kkhghD4?t=74 gives his house's location Atherton, California, part of Silicon Valley. youtu.be/tJ2-kkhghD4?t=279 shows his amazing garden a bit more.
A quick look on Google Maps show that that area is full of some incredible mansions. They managed to keep the entire place green, every house has a pool. Wikipedia comments web.archive.org/web/20220906010554/https://www.forbes.com/home-improvement/features/most-expensive-zip-codes-us/:
Atherton is known for its wealth; in 1990 and 2019, Atherton was ranked as having the highest per capita income among U.S. towns with a population between 2,500 and 9,999, and it is regularly ranked as the most expensive ZIP Code in the United States [(94027)]. The town has very restricting zoning, only permitting one single-family home per acre and no sidewalks. The inhabitants have strongly opposed proposals to permit more housing construction
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and Forbes confirms it for 2022: web.archive.org/web/20220906010554/https://www.forbes.com/home-improvement/features/most-expensive-zip-codes-us/, by far on top.
youtu.be/ZgAreiFXhJk?t=253 lists some famous people who live there. It's like a micro heaven.
And a person who makes open educational content like Marc, truly deserves it.
Video 2.
Soyuz Clock Part 4: How accurate is it? by CuriousMarc (2020)
Source. The timestamp youtu.be/HKsjwT53yXw?t=580 mentions that his wife is called "Laurie", and that she escaped the Soviet Union, and two of her brothers went to jail in the escape process.
Microscopy connectome extraction Updated +Created
This is the most plausible way of obtaining a full connectome looking from 2020 forward. Then you'd observe the slices with an electron microscope + appropriate Staining. Superintelligence by Nick Bostrom (2014) really opened Ciro Santilli's eyes to this possibility.
Once this is done for a human, it will be one of the greatest milestone of humanities, coparable perhaps to the Human Genome Project. BUt of course, privacy issues are incrediby pressing in this case, even more than in the human genome project, as we would essentially be able to read the brain of the person after their death.
As of 2022, the Drosophila connectome had been almost fully extracted.
This is also a possible path towards post-mortem brain reading.
Figure 1. Source. Unconfirmed, but looks like the type of frozen brain where a Microtome would be used.
Myoglobin Updated +Created
From Wikipedia:
In humans, myoglobin is only found in the bloodstream after muscle injury.
Paleolithic Updated +Created
This period is similar to the Quaternary, but it also includes tool usage by close relatives of humans which were not humans yet.
It ends together with the pleistocene.
Roche Biochemical Pathways Updated +Created
TODO human presumably?
I don't think it has any advantage over KEGG however, besides historical interest? Maybe slightly more manual layout and so more beautiful?
James Somers (rightly) likes to point to it as a "biology is awesome" thing.
Ron Maimon Updated +Created
Ron Maimon is a male human theoretical physicist with an all but dissertation started in 1995 at Cornell University[ref][ref].
Figure 1.
Ron Maimon's Physics Stack Exchange profile picture
. Source.
Ron is mostly known for simultaneously:
Ron seems to share a few philosophies which Ciro greatly agrees with as part of Cirism, which together with his knowledge of physics, make Ciro greatly respect Ron. Such philosophies include:
However he also subscribes to some theories which Ciro Santilli considers conspiracy theories, e.g. his ideas about the Boston Marathon bombing that got him banned from Quora (a ban which Ciro strongly opposes due to freedom of speech concerns!), but the physics might be sound, Ciro Santilli does not know enough physics to judge, but it often feels that what he says makes sense.
chat.stackexchange.com/transcript/message/7104585#7104585 mentions that he was at Cornell University and did all but dissertation, but he mentions that he was still self-taught:
Eugene Seidel: On your personal info page you write that you are not a physics Ph.D. but does that mean you were a physics undergrad in college then went to grad school and finished ABD... or are you entirely self taught?
Ron Maimon: ABD. I am self- taught though, I only went to school for accreditation. I had a thesis worth of work at the time I left grad-school,
Eugene Seidel: ok thanks
Ron Maimon: I was just kind of sickened by academic stuff that was going on--- large extra dimensions were popular then.
Eric Walker: Anyway, thanks Ron -- I'll get back to you with more questions soon, I'm sure.
Ron Maimon: Also I was at Cornell, my advisor left for Cincinnatti, and I was not in very good standing there (I was kind of a jerk, as I still am). Some friends wanted to start a biotech company called "Gene Network Sciences", and I joined them.
This is corroborated e.g. at: web.archive.org/web/20201226171231/http://pages.physics.cornell.edu/~gtoombes/Student_Index.html (original pages.physics.cornell.edu/~gtoombes/Student_Index.html down as of 2023).
At youtu.be/ObXbKbpkSjQ?t=2454 from Video 1. "Ron Maimon interview with Jeff Meverson (2014)" he mentions his brother is a professor. At physics.stackexchange.com/questions/32382/could-we-build-a-supercomputer-out-of-wires-and-switches-instead-of-a-microchip confirms that his brother's name is "Gaby Maimon", so this neuroscience professor at the Rockerfeller University is likely him: www.rockefeller.edu/our-scientists/heads-of-laboratories/985-gaby-maimon/. Looks, age, location and research interest match.
Bibliography:
  • gmachine1729.livejournal.com/161418.html Ron Maimon answers about physics and math on Quora (part 1) by Sheng Li (2020) contains a selection of some amazing Ron Maimon posts
  • www.reddit.com/r/RonMaimon/ someone made a Reddit for him. Less than 100 users as of 2022, but has potential.
  • some Quora threads about him, oh the irony:
    • www.quora.com/Is-Ron-Maimon-actually-a-pioneer-or-a-jest
    • www.quora.com/Are-Ron-Maimons-answers-on-mathematics-physics-and-computer-science-factually-correct
    • www.quora.com/What-do-people-think-of-Ron-Maimons-paper-Computational-Theory-of-Biological-Function-I
    • www.quora.com/Who-is-Ron-Maimon/answer/Ron-Maimon
      I'm a physics grad school drop-out working in theoretical biology but I still do physics when I get a chance, but not right now because I am in a middle of a project to understand the properties of a certain virus as completely as possible.
      Also in a comment he explains something to a now deleted comment, presumably asking why he dropped out of grad school, and gives a lot more insight:
      It's a complicated boring story.
      I dropped out mainly to do biology with friends at a startup, because I figured out how you're supposed to do theory in biology, but also I truly believe it was next to impossible for me to get a degree without selling out, and I would rather be shot than write a paper with an idea I don't believe.
      My grad school phase was a disaster. I first worked for Eric Siggia, but I got away because he had me do something boring and safe, I figured I have only a limited number of years before I turn 30 and my brain rots, and I wasn't going to sell out and do second-rate stuff. I found a young guy at the department doing interesting things (Siggia was also doing interesting things, like RNA interactions, he just wouldn't assign any of them to ME), this was Philip Argyres, and got him to take me. Argyres wanted me to work on large-extra dimensions (this was 1998), but I made it clear to him that I would rather be boiled in oil. I worked a little bit on a crappy experimental setup that didn't work at all, because I didn't know enough about electromagnetic screening nor about how to set up experiment. But EVERYONE LOVED IT! This is also how I knew it was shit. Good work is when everyone hates it. But I learned Lifschitz's ideas for quantum electrodynamics in media from this project.
      Me and every competent young person in high-energy physics knew large extra dimensions was a fraud on the day it came out, and I had no intention of doing anything except killing the theory. Once Wikipedia appeared, I did my best to kill it by exposing it's charlatanry on the page for large extra dimension. That was in 2005 (after getting fired from the company), and from this point onward large-extra-dimensions lost steam. But I can't tell how much of this was my doing.
      Argyres liked N=2 theory, and we did something minor in N=2 SUSY models around 2000, but I was bogged down here, because I was trying to do Nicolai map for these, and it ALMOST worked for years, but it never quite worked. But I knew from the moduli interpretation and Seiberg-Witten solution that it must work. If I live long enough, I'll figure it out, I am still sure it isn't hard. But this was the link to statistical stochastic models, the work I was doing with Jennifer Schwarz, and I wanted to link up the two bodies of work (they naturally do through Nicolai map).
      But I had my own discovery, the first real discovery I made, in 1999, this thing that I called the mass-charge inequality, what Vafa and Motl called "the weakest-force principle" when they discovered it in 2006. It was swampland, and Vafa hadn't yet begun swampland. My advisor didn't believe my result was correct, because he saw me say many stupid things before this. So he wouldn't write it or develop it with me (but I had read about Veltman telling 'tHooft he couldn't publish the beta-function, I knew Argyres was wrong about this)
      Anyway, Argyres left for Cincinnatti in 2000, and I joined the company then. I was in the company until january 2005. Then they fired me, which was ok, by then it was a miserable hell-hole full of business types.
      I discovered Wikipedia, and started killing large extra dimensions. I wanted to finish my thesis, and some people agreed to help me do this, but I had told myself "no thesis until you get the Nicolai map sorted out" and I never did. I worked with Chris Henley a little bit, who wanted me to do some stuff for him, and I discovered an interesting model for high-Tc, but Henley said it was out of fasion, and nobody would care, even though I knew it was the key to the phenomenon (still unpublished, but soon).
      This was 2008-2009, and I became obsessed with cold fusion, so Henley dropped me, as I had clearly gone crazy. I developed the theory of cold fusion during the last weeks of working for Henley. Then I dropped out for good.
      Honestly, by the time I was gone, I realized that the internet would make a degree counterproductive, because I knew I had better internet writing skills than any of the old people, I was a Usenet person. Online, the degrees and accreditation were actually a hinderance. So by this point, I secretly preferred not to have a PhD, because I knew I was good at physics, and I could attack from the outside and win. It's not too hard if you know the technical material.
      The only problem is that I was unemployed and isolated in Ithaca for about 7 years after having gone through my first productive phase. But I developed the cold-fusion ideas in this period, I learned a lot of mathematics, and I developed a ton of biology ideas that are mostly unpublished, but will be published soon. It astonished people that I could have no degree and be unemployed and have such a sky-high ego. The reason is that I could evaluate my own stuff, and I liked it!
Backlinks:
Video 1.
Ron Maimon interview with Jeff Meverson (2014)
Source. Ripped from Jeff's "Quoracast": player.fm/series/quoracast-podcast/ron-maimon-truther Ron mentions he was an early-Usenet user. Key points:
Sugar Updated +Created
We define a "sugar" as either of:because these are small carbohydrates, and they taste sweet to humans.