Angiotensin-converting enzyme 2 Updated 2025-07-16
UniProt human: www.uniprot.org/uniprot/Q9BYF1 It is interesting to see in the Mutagenesis how many known mutations can increase or decrease SARS-CoV-2 S protein binding affinity.
Ciro Santilli Updated 2025-07-16
Quick facts:
Other people with the same name are listed at Section "Ciro Santilli's homonyms".
Figure 1.
19th century illustration of the Journey to the West protagonist Sun Wukong
. Source.
Sun Wukong (孙悟空) is a playful and obscenely powerful monkey Journey to the West. He protects Buddhist monk Tang Sanzang, and likes eating fruit, just like Ciro. Oh, and Goku from Dragon Ball is based on him. His japanese name is "Sun Wukong" (same Chinese characters with different Japanese pronunciation) for the love. His given name "Wukong" means literally "the one who mastered the void", which is clearly a Dharma name and fucking awesome in multiple ways. This is another sad instance of a Chinese thing better known in the West as Japanese.
It is worth noting however that although Wukong is extremely charming, Ciro's favorite novel of the Four Great Classic Novels is Water Margin. Journey to the West is just a monster of the week for kids, but Water Margin is a fight for justice saga. Sorry Wukong!
Figure 2.
Ciro Santilli playing with a pipette at the University of Cambridge circa 2017
.
The photo was taken in an open event organized by the awesome Cambridge Synthetic Biology outreach group, more or less the same people who organize: www.meetup.com/Cambridge-Synthetic-Biology-Meetup/ and who helped organize Section "How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it".
Taking part in such activities is what Ciro tries to do to overcome his lifelong regret of not having done more experimental stuff at university. Would he have had the patience to handle all the bullshit of the physical word without going back to the informational sciences? Maybe, maybe not. But now he will probably never know?!
Notice the orange high visibility cycling jersey under the lab coat, from someone who had just ridden in from work as fast as possible as part of his "lunch break". It is more fun when it is hard.
Figure 3. .
Ciro Santilli fantasizes that he would have make a good scribe in the middle ages, partly due to his self diagnosed graphomania, but also appreciation for foreign languages, and his mild obsession with the natural sciences.
OurBigBook.com is Ciro's view of a modern day scriptorium, except that now the illuminations are YouTube videos.
The job of a Internet-age scribe is basically that of making knowledge more open, legally extracting it from closed copyrighted sources, and explaining your understanding of it to the wider world under Creative Commons licenses on the web. And in the process of greater openness, given a well organized system, we are able combine the knowledge of many different people, and thus make things more understandable than any single/few creator closed source source could ever achieve.
Ciro once saw some cartoon on Wikipedia help pages of a turtle with a book in one hand, and typing into Wikipedia on its computer, TODO find it. That cartoon summarizes well the modern scribe life.
Another analogous version of this fantasy more in touch with Ciro's sinophily is the ideal of the Chinese scholar, notably including their stereotypical attributes such as mastery of the Four arts.
Figure 4.
Ciro Santilli piling boxes as a child
. A natural born engineer.
These have almost certainly been transferred to nuclear DNA in the course of evolution.
This isn't completely surprising, since when mitochondria die, their DNA is kind of left in the cell, so it is not hard to imagine how genes end up getting uptaken by the nucleus. This is suggested at Power, Sex, Suicide by Nick Lane (2006) page 196.
A limiting factor appears to be that you can't just past those genes in the nucleus, further mutations are necessary for mitochondrial protein import to work, apparenty some kind of tagging with extra amino acids.
However, you likely don't want to remove all genes from the mitochondria because mitochondria have DNA because they need to be controlled individually.
Microscopy connectome extraction Updated 2025-07-16
This is the most plausible way of obtaining a full connectome looking from 2020 forward. Then you'd observe the slices with an electron microscope + appropriate Staining. Superintelligence by Nick Bostrom (2014) really opened Ciro Santilli's eyes to this possibility.
Once this is done for a human, it will be one of the greatest milestone of humanities, coparable perhaps to the Human Genome Project. BUt of course, privacy issues are incrediby pressing in this case, even more than in the human genome project, as we would essentially be able to read the brain of the person after their death.
As of 2022, the Drosophila connectome had been almost fully extracted.
This is also a possible path towards post-mortem brain reading.
Figure 1. Source. Unconfirmed, but looks like the type of frozen brain where a Microtome would be used.
Myoglobin Updated 2025-07-16
From Wikipedia:
In humans, myoglobin is only found in the bloodstream after muscle injury.
Paleolithic Updated 2025-07-16
This period is similar to the Quaternary, but it also includes tool usage by close relatives of humans which were not humans yet.
It ends together with the pleistocene.
Roche Biochemical Pathways Updated 2025-07-16
TODO human presumably?
I don't think it has any advantage over KEGG however, besides historical interest? Maybe slightly more manual layout and so more beautiful?
James Somers (rightly) likes to point to it as a "biology is awesome" thing.
Ron Maimon Updated 2025-07-26
Ron is mostly known for simultaneously:
Ron seems to share a few philosophies which Ciro greatly agrees with as part of Cirism, which together with his knowledge of physics, make Ciro greatly respect Ron. Such philosophies include:
However he also subscribes to some theories which Ciro Santilli considers conspiracy theories, e.g. his ideas about the Boston Marathon bombing that got him banned from Quora (a ban which Ciro strongly opposes due to freedom of speech concerns!), but the physics might be sound, Ciro Santilli does not know enough physics to judge, but it often feels that what he says makes sense.
chat.stackexchange.com/transcript/message/7104585#7104585 mentions that he was at Cornell University and did all but dissertation, but he mentions that he was still self-taught:
Eugene Seidel: On your personal info page you write that you are not a physics Ph.D. but does that mean you were a physics undergrad in college then went to grad school and finished ABD... or are you entirely self taught?
Ron Maimon: ABD. I am self- taught though, I only went to school for accreditation. I had a thesis worth of work at the time I left grad-school,
Eugene Seidel: ok thanks
Ron Maimon: I was just kind of sickened by academic stuff that was going on--- large extra dimensions were popular then.
Eric Walker: Anyway, thanks Ron -- I'll get back to you with more questions soon, I'm sure.
Ron Maimon: Also I was at Cornell, my advisor left for Cincinnatti, and I was not in very good standing there (I was kind of a jerk, as I still am). Some friends wanted to start a biotech company called "Gene Network Sciences", and I joined them.
This is corroborated e.g. at: web.archive.org/web/20201226171231/http://pages.physics.cornell.edu/~gtoombes/Student_Index.html (original pages.physics.cornell.edu/~gtoombes/Student_Index.html down as of 2023).
Bibliography:
Backlinks:
Video 1.
Ron Maimon interview with Jeff Meverson (2014)
Source. Ripped from Jeff's "Quoracast": player.fm/series/quoracast-podcast/ron-maimon-truther Ron mentions he was an early-Usenet user. Key points:
Sugar Updated 2025-07-16
We define a "sugar" as either of:because these are small carbohydrates, and they taste sweet to humans.