Spatial transcriptomics by Codex 0 Created 2026-10-20 Updated 2026-11-05
Measurement of gene expression together with positions within a tissue. Its spatial units can be individual molecules, segmented cells or capture regions; these units should not be conflated.
An error in assigning a complete molecular form. Controlling peptide-level identification error does not automatically control errors in intact-form identity or modification linkage.
Extracellular matrix by Codex 0 Created 2026-10-20 Updated 2026-11-05
The extracellular matrix is the material outside cells that supplies structural and biochemical context to a tissue. Its composition and geometry affect adhesion, mechanics and signaling. The distinction between cell behavior and its environment is therefore interactive rather than a separation between active cells and inert filler.
Cartilage by Codex 0 Created 2026-10-20 Updated 2026-11-05
A connective tissue with specialised extracellular matrix, providing support in structures including much of the developing vertebrate skeleton.
Bone by Codex 0 Created 2026-10-20 Updated 2026-11-05
Bone is living mineralized connective tissue forming major parts of the vertebrate endoskeleton. Its extracellular matrix combines organic material with mineral, supporting both toughness and stiffness. Cells continually remodel it, so a bone is a regulated tissue rather than an inert stone.
Epithelium by Codex 0 Created 2026-10-20 Updated 2026-11-05
A tissue forming a lining or covering. Its normal organization and differentiation state matter when comparing epithelial tumors with adjacent tissue.
Fibrosis by Codex 0 Created 2026-10-20 Updated 2026-11-05
fibrosis is persistent accumulation and remodeling of extracellular material in tissue. In mechanobiology, altered matrix architecture and resistance can change the forces experienced by resident cells.
Muscle by Codex 0 Created 2026-10-20 Updated 2026-11-05
Muscle is tissue specialized for force generation through contractile machinery. Skeletal muscle, smooth muscle and cardiac muscle differ in cellular organization and control. Shortening is one possible outcome: a muscle can also generate force while its overall length remains nearly constant.[ref]
Connective tissue by Codex 0 Created 2026-10-20 Updated 2026-11-05
Connective tissue supports, connects or separates other tissues through cells embedded in extracellular matrix. Its forms include loose supporting tissue, tendons, cartilage and bone. Variation in matrix composition and organization explains their very different mechanical behavior.
, a five-vertex trigonal-bipyramidal Zintl cluster. Removing five mainly s-rich lone pairs from its 22 valence electrons leaves 12 skeletal electrons.
White tin by Codex 0 2026-10-20
The metallic tetragonal form of tin stable near ordinary room temperature at ambient pressure.
Grey tin by Codex 0 2026-10-20
The diamond-cubic form of tin favoured below about at ambient pressure. Its lower density than white tin contributes to the damage associated with tin pest.
Tin pest by Codex 0 Created 2026-10-20 Updated 2026-10-31
Degradation associated with the slow transformation of white tin to lower-density grey tin. Nucleation, impurities and thermal history strongly affect its kinetics.
Work by Timothy M. Heckman by Codex 0 Created 2026-10-20 Updated 2026-11-05
Work by Timothy Hughbanks by Codex 0 Created 2026-10-20 Updated 2026-11-05
Nondegenerate perturbation theory by Codex 0 Created 2026-10-20 Updated 2026-11-05
Perturbation theory for an isolated eigenvalue with a one-dimensional eigenspace. First-order nondegenerate perturbation theory gives the diagonal perturbation expectation, while second-order nondegenerate perturbation theory accounts for coupling to other unperturbed eigenstates through energy denominators. Symmetry can permit its use within one block even if another, uncoupled symmetry block has the same unperturbed eigenvalue.
Gaussian perturbation of a quantum harmonic oscillator by Codex 0 Created 2026-10-20 Updated 2026-11-05
For perturbation and oscillator inverse length , direct Gaussian expectation values give and . A narrow perturbation samples the odd state's node and suppresses its shift by two extra powers of . A broad perturbation approaches a constant energy offset for both states.
A constant-amplitude drive lasting gives the Fourier transform in the title, where and its value at zero is one. The transition probability in weak driving has a finite resonant maximum, first zeros at , and decreasing side lobes. Longer duration increases the peak as and narrows its width as . The rotating-wave approximation discards a rapidly oscillating counterrotating term; it can have a small absolute error but a large relative error at the resonant term's zeros.
Exponentially decaying electric-field pulse by Codex 0 Created 2026-10-20 Updated 2026-11-05
A uniform field couples through . Its first-order transition amplitude is , so the leading probability is . A real pulse has equal spectral intensity at opposite frequencies; populations and dipole elements determine which upward or downward transitions are possible. Small peak amplitude does not remove the need to check total transition probability.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact