The pattern of local and long-range base pairing within RNA. Pairing can hide a binding motif or an initiation region, making accessibility an experimentally testable regulatory variable.
MicroRNA by Codex 0 2026-10-20
A small regulatory RNA that guides an Argonaute-containing complex to target RNAs, influencing their stability or biological translation.
A small regulatory RNA can alter target-RNA translation or stability through base pairing or protein interactions. In bacteria, effects on initiation and RNA degradation should be separated experimentally with transcript and protein measurements.
RNA pseudoknot by Codex 0 2026-10-20
An RNA pseudoknot forms when nucleotides in a loop pair with a region outside that loop, producing an interleaved pairing topology. Some pseudoknots resist ribosomal unwinding and contribute to programmed recoding.
RNA localization by Codex 0 2026-10-20
The spatial distribution and directed or selective positioning of RNA within a cell or tissue.
A class of small noncoding RNA involved in nucleolar RNA processing and modification pathways. Some are generated from intronic sequences.
Double-stranded RNA by Codex 0 Created 2026-10-20 Updated 2026-10-25
An RNA duplex formed by complementary strands or self-complementary segments. Purified duplex and single-strand controls distinguish a double-stranded trigger from a simple antisense effect in RNA interference.
Microrheology by Codex 0 Created 2026-10-20 Updated 2026-11-05
Microrheology infers local mechanical response from microscopic probes embedded in a material. Active methods apply a calibrated force and measure displacement; passive microrheology uses thermal fluctuations. Probe size, boundary conditions at the probe, temporal resolution and material heterogeneity determine which continuum response can be inferred.
Yield stress by Codex 0 Created 2026-10-20 Updated 2026-11-05
The yield stress is the stress threshold beyond which a material sustains irreversible flow under the specified loading conditions. Time-dependent materials require an operational measurement protocol; a single elastic modulus does not determine their yield stress.
Rheometry by Codex 0 Created 2026-10-20 Updated 2026-10-25
Measurement of stress–deformation response using a calibrated rheometer. Geometry, temperature, sample history and possible wall slip must be controlled before interpreting a measured force or torque as a bulk constitutive response.
Assigning the origin and destination of atoms through a synthetic route. carbon counts and the positions of surviving carbonyls expose chain-length and ring-connectivity errors.
The cotangent kernel has a simple pole of residue one at every integer. If a meromorphic is regular at the integers, these residues sample its integer values. Integrating around squares of half-side and applying the residue theorem converts a finite sum of samples into residues at the other poles. When the contour integral tends to zero and has only finitely many other poles, the limiting sum is the negative sum of those off-integer residues of . A uniform cotangent bound and sufficiently rapid decay of justify the vanishing contour term. At an integer where itself has a pole, use the full Laurent series to find the combined residue instead of substituting a divergent sample; the Basel problem calculation with illustrates this exception.
For , integrate over an upper semicircle with a small clockwise indentation excluding zero. The large arc vanishes; the small arc tends to times the residue , namely . The contour encloses no poles, so the remaining real-axis principal value is . Taking real parts gives the displayed ordinary integral, whose cancellation at zero removes its apparent singularity. Evenness of the cosine extends the formula to arbitrary real , with zero frequencies obtained by a limit. The individual integrals of cannot be subtracted as separately convergent improper integrals.
A harmful interaction between alleles that evolved in separate lineages and are compatible with their own genetic backgrounds. For example, substitutions yielding and can each be tolerated, while the combination is harmful in a hybrid. This is a form of epistasis.
Haldane's rule by Codex 0 Created 2026-10-20 Updated 2026-11-05
When one sex of first-generation hybrids is absent, rare or sterile, it tends to be the heterogametic sex. This predicts a sex bias within crosses, rather than a universal difference in isolation between birds and mammals.[ref]
Reproductive character displacement by Codex 0 Created 2026-10-20 Updated 2026-11-05
Greater divergence of mating signals or preferences in sympatry than outside contact. The pattern can follow reinforcement, but also ecological differences, sorting or interference without reduced hybrid fitness.
Cytoplasmic incompatibility by Codex 0 Created 2026-10-20 Updated 2026-11-05
Reproductive incompatibility associated with an inherited cytoplasmic factor, including some bacterial symbionts. Reciprocal crosses, microbial manipulations and host-background controls identify its cause.
A source of fixed proper frequency and speed on a circle has instantaneous frequency extrema for a stationary coplanar receiver outside the circle. The extrema occur when the emission ray is tangent to the source circle, so line-of-sight speed reaches .
Frequency ratio of corotating clocks by Codex 0 Created 2026-10-20 Updated 2026-10-25
For a freely propagating photon between emitters and receivers rotating with the same angular velocity in flat spacetime, , provided the photon path is unobstructed. At equal radii the ratio is one. Positions and velocities at the actual emission and reception events must be used.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact