Bayes' theorem updates prior knowledge using the likelihood of new observations. For alternative hypotheses ,
The prior describes information before the data ; is the sampling likelihood, and the posterior describes the updated probabilities. Posterior odds equal prior odds times the likelihood ratio. A likelihood is a probability model for data at specified parameters, not automatically a normalized probability distribution over those parameters.
For a continuous parameter , the same rule uses densities: . Priors can encode positivity, physical limits, previous independent measurements or calibration knowledge. Their parameterization matters: a density uniform in a rate is not uniform in its logarithm. Proper priors make model evidences well defined; an arbitrary normalization in an improper prior is especially problematic for comparing models.
A counting example uses Poisson-gamma conjugacy. If a detector registers events in exposure with constant rate , . A gamma prior with shape and rate parameter , , gives
The posterior mean combines the prior rate with the observed rate , weighted by the prior and actual exposures. The parameters must use a consistent shape-rate convention. Small counts can leave substantial prior sensitivity; abundant informative data usually reduce it for regular identifiable models.
Independent old data can become the prior for a new experiment, giving the same result as joint updating under a consistent model. The new data must not also have been used to construct that prior, or the evidence is counted twice. A credible interval has a specified posterior probability under the chosen model and prior; this interpretation differs from repeated-sampling coverage of a confidence interval. Predictions for a future observation average its sampling distribution over the posterior, incorporating parameter uncertainty. Prior sensitivity checks and a defensible likelihood are therefore part of the inference, rather than Bayes' theorem itself supplying missing physical knowledge.
A systematic error is a reproducible bias in the measurement model or procedure, such as a zero offset, incorrect gain, background contamination, misalignment, loading or temperature-dependent calibration. Repeating the same biased procedure more often reduces independent random scatter but does not remove the bias. An unknown correction also has a measurement uncertainty, even when the mechanism is systematic.
A simple instrument model is , with gain error , offset , drift and random noise . Comparison with calibrated standards at several input values separates an offset from a scale error and can test nonlinearity. Use standards that cover the operating range, verify units and reference values, and propagate uncertainty in the standards into the corrected result. Calibration changes the model; it does not make the corrected measurement exact.
A blank or source-off measurement estimates additive background. For independent source-plus-background count in time and background count in time , the net-rate estimate and its counting variance are
Subtracting a measured background removes its estimated mean, not its fluctuations or its uncertainty. A long background exposure can reduce the latter, while drifting backgrounds require monitoring or a joint model.
Reversal can distinguish a wanted signal from an unchanged offset. For example, and give when the thermoelectric offset is stable between readings. Interchanging sample and reference, reversing field direction or reversing an apparatus orientation can similarly expose sign-dependent biases, but only if the wanted and unwanted contributions transform differently.
Track slow instrumental drift using frequent references, interleaved readings or an ABBA measurement sequence. Equal-time readings in the order A, B, B, A cancel a common linear drift in the difference estimator . Nonlinear drift or unequal sample conditions can survive. Randomizing run order helps prevent a time drift from imitating dependence on a controlled experimental variable.
Control physical couplings directly: stabilize temperature, minimize gradients, shield unwanted fields, align geometry, and use high input impedance when loading is the concern. Differential and bridge measurements suppress common changes when their channels are well matched. Varying an apparatus parameter or using an independent method can reveal an unsuspected bias. Report residual corrections, their uncertainties and correlations; adding more identical readings cannot justify discarding a shared calibration uncertainty.
Johnson-Nyquist noise is equilibrium electrical fluctuation caused by thermal agitation of charge carriers. A resistor can generate a fluctuating terminal voltage even when its mean current is zero. In the classical frequency range , the Fluctuation-dissipation theorem relates this noise to dissipative resistance. The one-sided voltage power spectral density of an unloaded resistor is
Equivalently its short-circuit current spectrum is . Over a flat bandwidth the rms voltage is . A real measurement instead integrates over positive frequency, with loading and the filter's effective noise bandwidth included. A flat spectrum does not imply an infinite physically measurable variance; the circuit and the quantum high-frequency regime limit the ideal white-noise model.
Cooling or narrowing the accepted bandwidth reduces thermal noise. Reducing resistance lowers its open-circuit voltage noise but raises its short-circuit current noise, so the appropriate choice depends on source impedance and amplifier loading. Thermal agitation is not a fluctuating externally applied voltage that can be removed by perfect shielding alone.
Shot noise arises from discrete transfer events. In the simplest shot noise counting model, equal charges arrive independently at constant rate . A gate of duration contains a Poisson number , with mean and variance . Therefore mean current is , and the averaged-current variance is . The corresponding one-sided low-frequency spectrum is
for a flat accepted bandwidth. Electron current has . Vacuum emission or photodetection can approximate independent arrivals; correlations in a conductor can suppress or enhance the fluctuations. Discreteness by itself does not guarantee Poisson statistics.
For a fixed mean current the ideal shot-noise formula is not proportional to temperature, whereas Johnson noise is. Increasing current raises absolute shot noise but lowers its fractional size, since . Both can appear approximately white within a useful frequency band, and independent noise powers add after referring them to a common measurement point. Their spectra must use the same convention: two-sided densities are half these one-sided values. A real low-current experiment can also contain amplifier noise, low-frequency drift and correlated transfer noise, so a mean current or resistance alone does not specify its complete noise budget.

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