Aalen–Johansen estimator Created 2026-10-06 Updated 2026-10-07
The Aalen–Johansen estimator is a product of empirical state-transition matrices over event times. In competing risks, the estimated cumulative incidence function for cause jumps by , while overall survival is updated using all event causes. Right censoring changes subsequent risk sets but does not itself create a probability jump.
At-risk process 2026-09-24
Background hazard 2026-10-14
In relative survival, the background hazard is an individual's expected mortality hazard in a suitable reference population. Its dependence on age, sex and calendar time can be obtained from population life tables. In a heterogeneous cohort, estimating a common excess hazard requires averaging these known background hazards over the current risk set, rather than over the original cohort.
Breslow approximation for tied event times Created 2026-10-06 Updated 2026-10-14
When events occur at the same recorded time, the Breslow approximation to Cox partial likelihood uses the factor , where is the risk set and the event set. It approximates the ordering of tied events rather than treating their within-tie order as known.
Breslow estimator 2026-09-28
The Breslow estimator of the baseline cumulative hazard in a Cox proportional-hazards model adds the observed number of events at each event time divided by the sum of fitted relative risks in its risk set.
Constrained Kaplan–Meier estimator 2026-10-14
The Kaplan–Meier estimator constrained to have survivor function value at maximizes the right-censoring log-likelihood subject to the displayed constraint. Here is the discrete hazard, the event count and the risk set size. In an interior event-time solution, a Lagrange multiplier gives before the constrained time, with afterwards. The multiplier is chosen to satisfy the product constraint. It is essential to allow a zero-event jump at the constrained time or another relevant cell boundary: a constraint can require mass outside observed event times. A general implementation instead maximizes the concave probability-mass log-likelihood with total mass one and mass above equal to , allowing all relevant cells and a terminal tail. This also handles unobserved tails and boundary solutions without imposing unjustified event-only support.
For competing risks, a cumulative incidence function jumps by the displayed Aalen–Johansen estimator increment. A person right-censored at exactly the event time remains in the immediately preceding risk set under the usual events-before-censoring tie convention. Censoring changes the next risk set, not the current event numerator or survival jump.
Discrete hazard Created 2026-10-07 Updated 2026-10-14
At ordered possible failure times , the discrete hazard is . Its survival function satisfies , and hence . Estimating by the observed number of failures divided by the risk set size under independent censoring yields the Kaplan–Meier estimator. Unlike a continuous-time hazard rate, a discrete hazard is a probability between zero and one.
Efron approximation for tied event times 2026-10-14
For events tied within a risk set, put , and . The Efron approximation to Cox partial likelihood removes the average tied-event hazard multiplier from the denominator at each successive event. Unlike the Breslow approximation for tied event times, it accounts approximately for depletion of the risk set within the group. Factors independent of can be dropped for estimation. This is an approximation for coarsened continuous event times, not a full interval-observation likelihood.
Exact tied-set conditional likelihood 2026-10-14
In a discrete-time model with independent event indicators whose odds are , condition on exactly events in the risk set . The common factor cancels and the conditional probability of the event set is the displayed ratio. The denominator is an elementary symmetric polynomial and can be evaluated by recursion rather than enumerating every subset. This conditional model is distinct from summing a continuous-time rank likelihood over all unobserved within-tie orders.
Even with a common event hazard, the exact expectation of the Nelson–Aalen estimator is , because no increments can be observed after the risk set is empty. Replacing ratios by ratios of expectations gives an approximate target and does not prove finite-sample unbiasedness. For one uncensored exponential event time, the estimator has mean rather than .
Fractional event imputation 2026-10-06
Greenwood formula 2026-10-14
For the Kaplan–Meier estimator, the estimated variance isThe formula follows by summing approximate variances of the logarithms of the conditional survival factors and applying the delta method to their product. Its square root is the estimated standard error. The same expression uses the actual delayed-entry risk sets for the Kaplan–Meier estimator with delayed entry. When and every contributing , an approximate log-scale confidence interval is , with the upper endpoint capped at one. This interval can be inaccurate with very small risk sets.
Grouped Nelson–Aalen event-count identity 2026-10-14
Suppose everyone enters observation at zero and has one event or censoring time. At distinct recorded time , let observations terminate, of which are events, and use the pre-time risk set size . For the grouped Nelson–Aalen estimator, . Exchanging sums gives . The unweighted sum over distinct times generally does not have this property. Processing each observation separately after breaking ties also restores the corresponding unweighted identity on the resulting artificial time grid.
Independent censoring Created 2026-09-28 Updated 2026-10-14
A simple sufficient independent censoring assumption is that the potential observation-ending time and survival time are independent random variables. More generally, appropriate conditional independence given the covariates used in the analysis can suffice for analysis within those conditions. The requirement concerns the potential times, rather than independence of the observed duration and event indicator : those recorded quantities ordinarily depend on each other.
For an ordinary pooled Kaplan–Meier estimator, the observed risk set must represent the future event experience of everyone still event-free at each time. Conditional independence given a covariate does not alone justify ignoring that covariate in a pooled calculation. Also, there must be a positive probability of remaining observed through the horizons being estimated. If follow-up ends at a common closing time, it supplies no observations to identify the later survival function. Independent subjects with a common survival distribution and independent censoring form the basic model in Lu Tian's STAT331 notes, Unit 3, pages 1–4.
For example, subjects who stop attending because their condition is deteriorating can produce informative censoring. A predetermined common closing date can instead give administrative censoring, provided calendar entry and other relevant conditions do not select future survival times. The reason for stopping observation must be justified from study design and context; the recorded event indicators alone cannot verify independent censoring.
Kaplan–Meier estimator Created 2026-09-24 Updated 2026-10-14
At distinct observed event times , let be the risk set size immediately before , and let count events at . The Kaplan–Meier estimator of the survival function isThe empty product is one. Each factor estimates a conditional survival probability among those still observed and event-free; their product joins the successive steps. This is nonparametric statistics: no specified shape for the survival distribution is imposed. Use independent censoring and the appropriate risk sets to interpret the result as an estimate for the intended population.
The Kaplan–Meier estimator is a right-continuous function with downward jumps at event times. Right censoring changes later denominators without causing a jump. A tick on the curve marks right censoring, rather than a failure. For a tied group of events, use the one factor ; subjects right-censored at that recorded time remain in for this factor. The fraction estimates a discrete hazard, not a continuous hazard function in inverse-time units. With no censoring, the factors telescope to the fraction of the original cohort whose observed survival times exceed , the complement of its empirical distribution function.
Edward L. Kaplan and Paul Meier published [ref]
https://doi.org/10.1080/01621459.1958.10501452. Nonparametric Estimation from Incomplete Observations, Journal of the American Statistical Association 53(282), 457–481 (1958)
. Their paper addresses lifetime estimation when observation ends before failure and explicitly calls attention to the assumption of independence between lifetime and potential observation loss. The date 1958 is the original publication year; the publisher's later online-posting date is not the discovery date.In his [ref]
https://garfield.library.upenn.edu/classics1983/A1983QS51100001.pdf. 1983 Citation Classic recollection
, Kaplan traces Meier's interest to cancer-duration data in 1952 and his own to the lifetimes of vacuum tubes in undersea telephone-cable equipment a year later. The journal encouraged them to combine their manuscripts. The shared mathematical question was how to estimate a survival function when some lifetimes are still running or disappear from observation. Kaplan–Meier estimator with delayed entry 2026-10-14
For independently left-truncated and right-censored survival data, let and be entry and exit times on the same clock. At each distinct event time , the risk set is , with size , and events occur. The Kaplan–Meier estimator isBefore entry a subject contributes neither an event nor time at risk. Thus adding observed entrants can increase successive risk sets; pretending that all subjects were observed from time zero distorts the estimated hazard function. The estimator identifies the survival function over ages covered by observation; normalization from birth requires observation arbitrarily close to time zero or additional knowledge of earlier survival.