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Power, Sex, Suicide by Nick Lane (2006) part 5 "Murder or suicide" mentions that apoptosis has two main functions:
- prevent cancer
- but it is also an important part of body development, e.g. fingers are separated because cells between them kill themselves. Otherwise we would have webbed feet like ducks. There is also a lot of apoptosis during the development of the brain. This has been observed notably in C. elegans see also: Section "C. elegans cell lineage".
- superuser.com/questions/133082/what-is-the-difference-between-hyper-threading-and-multiple-cores/995858#995858
- stackoverflow.com/questions/680684/what-are-the-differences-between-multi-cpu-multi-core-and-hyper-thread/73405312#73405312
- unix.stackexchange.com/questions/88283/so-what-are-logical-cpu-cores-as-opposed-to-physical-cpu-cores/739296#739296
Hyperthreding is the Intel brand-name, TODO generic name.
Examples under cmake:
- cmake/hello: just print a message in CMake itself and exit. No compilation.
- cmake/hello_c: C hello world
- cmake/option:
set()andoption()basic examples - cmake/multi_executable
- cmake/multi_file
- cmake/multi_file_recursive
- cmake/shared_lib_external
Find UTF-8 strings with Binutils 
Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
strings (Binutils) by Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01 Power, Sex, Suicide by Nick Lane (2006) by Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01All pages below are from the second edition from 2018. It seems that there weren't any changes in the text, the updated preface mentions
As it happens, nearly 15 years have passed since the 1st edition of Power, Sex, Suicide was published, and I am resisting the temptation to make any lame revisions. Some say that even Darwin lessened the power of his arguments in the Origin of Species through his multiple revisions, in which he dealt with criticisms and sometimes shifted his views in the wrong direction. I prefer my original to speak for itself, even if it turns out to be wrong.
This is partly addressed in the preface of the second edition from 2018.
Central thesis:
- there are two sexes because of mitochondria
- the acquisition of mitochondria was one of the most important steps in the evolution of eukaryotes.There are no known eukaryotes which never had mitochondria. Having mitochondria appears to be a requisite for being an eukaryote.Contrast this for example with multicellularity, which is highly polyphyletic.
- Apoptosis is largely regulated by mitochondria
- there are two main theories for how the mitochondria endosymbiosis started:
- parsitic hypothesis of mitochondrial endosymbiosis: a parasitic option rather than cooperative
- hydrogen hypothesis: a cooperative option rather than parasitic
Smaller points:
- 10% of our body weight (dry presumably?) is mitochondria. Also quoted at: www.nature.com/scitable/blog/student-voices/mighty_mitochondria. TODO confirm.
- eukaryotes can do phatocytosis due to their cytoskeleton
- paints a colorful picture of Peter Mitchell. Some Wikipedia edits are warranted!
- it is hard for complex organisms to evolve because longer DNA means longer replication time
- cancer is natural selection gone wrong
- multicellular organisms are not utopias where every cell lives happily. Rather, they are dictatorships, where any dissident is forced to commit seppuku. Lu Xun's petition quote comes to mind.
Nitpicks:
- the book calls ATP synthase "ATPase" in several points, which is confusing because -ase means "something that breaks", and in 2020 parlance, there are ATPases which actually break ATP: en.wikipedia.org/wiki/ATPase. The book itself acknowledges that on page 135:
The ATPase is freely reversible. Under some circumstances it can go into reverse, whereupon it splits ATP, and uses the energy released to pump protons up the drive shaft, back across the membrane against the pressure of the reservoir. In fact the very name ATPase (rather than ATP synthase) signifies this action, which was discovered first. This bizarre trait hides a deep secret of life, and we’ll return to it in a moment.
Some criticisms:
- some of the later chapters are a bit more boring, like the stuff about warm-blooded animals. Perhaps is it that Ciro Santilli is more interested in the molecular aspects than macro
- the author talks about some very recent research at the time. While this does highlight his expertise, some of the points mentioned might still be in a state of flow. This is acknowledged by the author himself on the 2018 updated preface however.
Dude's a legend. Sells company for a few million. Then forks the open source project next year. Love it.
Proponent of evergreen notes.
He's also curious about quantum computing: quantum.country/ like Ciro Santilli. Some crazy overlaps we get.
Ciro Santilli found out that he likes computer security researchers and vice versa.
It's a bit the same reason why he likes physicists: you can't bullshit with security.
You can't just talk nice and hope for people to belive you.
You can't not try to break things and just keep everyone happy in their false illusion of safety.
You can't do a half job.
If you do any of that, you will get your ass handed to you in a little gift bag.
All of this is closely linked to Ciro Santilli's self perceived creative personality and being naughty and creative are correlated.
Follow car terminology and be done with it. Also follows marking of all bike shifters.
Rear bicycle derailleur does not shift up by Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01Full range achieved, going from fastest to slowest works (downshift), but going from slowest to next slowest (upshift) fails. Limits are good, B-tension screw didn't help
- bicycles.stackexchange.com/questions/66811/rear-derailleur-does-not-downshift-properly-shifts-up-smoothly likely good question but with wrong up vs down terminology
Gift vs Grant vs Contract in the United Kingdom by Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
Isothermal DNA amplification techniques by Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01
Ciro Santilli 35 Updated 2025-01-10 +Created 1970-01-01Isothermal means "at fixed temperature".
This is to contrast with the more well established polymerase chain reaction, which requires heating and cooling the sample several times.
The obvious advantage of isothermal methods is that their machinery can be simpler and cheaper, and the process can happen faster, since you don't have to do through heating and cooling cycles.
TODO find the best source for the amazing "I have done your mother" quote.
Pinned article: ourbigbook/introduction-to-the-ourbigbook-project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivative - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 4. Visual Studio Code extension tree navigation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. - Internal cross file references done right:
- Infinitely deep tables of contents:
Figure 6. Dynamic article tree with infinitely deep table of contents.Live URL: ourbigbook.com/cirosantilli/chordateDescendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact