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This resonates a lot with Ciro Santilli's ideas!
- physics and the illusion of life
- physics education needs more focus on understanding experiments and their history:
- Education is broken
- molecular biology feels like systems programming
I've never come across a subject so fractal in its complexity. It reminds me of computing that way.
Like PCR, but does not require thermal cycling. Thus the "isothermal" in the name: iso means same, so "same temperature".
Not needing the thermo cycling means that the equipment needed is much smaller and cheaper it seems.
One single universal wavefunction, and every possible outcomes happens in some alternate universe. Does feel a bit sad and superfluous, but also does give some sense to perceived "wave function collapse".
This step is genius because sequencing is basically a signal-to-noise problem, as you are trying to observe individual tiny nucleotides mixed with billions of other tiny nucleotides.
With bridge amplification, we group some of the nucleotides together, and multiply the signal millions of times for that part of the DNA.
Instead of trying to dominate the sequencing market and gain trillions of dollars from it, they local British early stage investors were more than happy to get a 20x return on their small initial investments, and sold out to the Americans who will then make the real profit.
And now Solexa doesn't even have its own Wikipedia page, while Illumina is set out to be the next Microsoft. What a disgrace.
Cambridge visitors can still visit the Panton Arms pub, which was the location of the legendary "hey we should talk" founders meeting, chosen due to its proximity to the chemistry department of the University of Cambridge.
In 2021 the founders were awarded the Breakthrough Prize. The third person awarded was Pascal Mayer. He was apparently at Serono Pharmaceutical Research Institute at the time of development. They do have a wiki page unlike Solexa: en.wikipedia.org/wiki/Serono. They paid a 700 million fine in 2005 in the United States, and sold out in 2006 to Merck for 10 billion USD.
Bibliography:
- medium.com/@nick.mccooke/how-we-pioneered-next-generation-dna-sequencing-at-solexa-61bac41aedd2 How We Pioneered Next Generation DNA Sequencing At Solexal by Nick McCooke 2025. This article series could be very interesting.
One reasonable and memorable approximation excluding any fine structure is:see for example example: hydrogen 1-2 spectral line.
Equation 1.
Hydrogen spectral series mnemonic
. Kind of a synonym for hydrogen emission spectrum not very clear if fine structure is considered by this term or not.
A line set for hydrogen spectral line.
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